Young Age and Concomitant Cannabis (THC) and Ethanol (EtOH) Exposure Enhances Rat Brain Damage Through Decreased Cerebral Mitochondrial Respiration

The reason why young people taking concomitantly cannabis (THC) and ethanol (EtOH) are more prone to stroke is underresearched. To investigate whether an underlying mechanism of increased brain damage could be an impaired mitochondrial function, this experiment determined the acute effects of EtOH,...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 30; no. 4; p. 918
Main Authors:	Quenardelle, Véronique, Charles, Anne-Laure, Charloux, Anne, Raul, Jean-Sébastien, Wolff, Valérie, Geny, Bernard
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 17.02.2025 MDPI
Subjects:	Age Alcohol Animals Brain Brain - drug effects Brain - metabolism Brain - pathology Brain Injuries - chemically induced Brain Injuries - metabolism Brain Injuries - pathology cannabis Cannabis - adverse effects Cannabis - chemistry Cell Respiration - drug effects Cognition & reasoning Dronabinol - adverse effects Dronabinol - pharmacology Drug dosages Ethanol Ethanol - adverse effects Ethanol - pharmacology Ethanol - toxicity EtOH Heart attacks Hydrogen Peroxide - metabolism Hypothesis testing Male Marijuana Mental disorders mitochondria Mitochondria - drug effects Mitochondria - metabolism Neuropsychology Oxidative Stress - drug effects Protons Rats Respiration Stroke Tetrahydrocannabinol THC Young adults mitochondria cannabis EtOH hydrogen peroxide (H2O2) brain ethanol stroke THC oxidative stress mitochondrial respiration
ISSN:	1420-3049, 1420-3049
Online Access:	Get full text
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