Apoptotic and non-apoptotic cell death induced by cis and trans analogues of a novel ammine(cyclohexylamine)dihydroxodichloroplatinum(IV) complex

It has been previously demonstrated that cisplatin induces apoptosis in the CH1 human ovarian carcinoma cell line. This study demonstrates that two novel platinum (Pt) analogues JM149 and JM335, which are the cis and trans geometry respectively of ammine(cyclohexylamine)dihydroxodichloroPt(IV), init...

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Bibliographic Details
Published in:	British journal of cancer Vol. 74; no. 7; p. 1037
Main Authors:	O'Neill, C F, Ormerod, M G, Robertson, D, Titley, J C, Cumber-Walsweer, Y, Kelland, L R
Format:	Journal Article
Language:	English
Published:	England 01.10.1996
Subjects:	Antineoplastic Agents - pharmacology Apoptosis Cell Cycle - drug effects Cell Death DNA, Neoplasm - drug effects DNA, Neoplasm - metabolism Drug Screening Assays, Antitumor Female Flow Cytometry Humans Isomerism Organoplatinum Compounds - pharmacology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Platinum - metabolism Time Factors Tumor Cells, Cultured
ISSN:	0007-0920
Online Access:	Get more information
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