Quality of Life of Japanese Dysmenorrhea/Heavy Menstrual Bleeding Patients Treated with Levonorgestrel Intrauterine Delivery System in a Real-World Setting

Introduction The present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who underwent insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg. We aimed to evaluate the quality of life (Q...

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Published in:	Advances in therapy Vol. 39; no. 8; pp. 3616 - 3634
Main Authors:	Momoeda, Mikio, Akira, Shigeo, Harada, Tasuku, Kitawaki, Jo, Maeda, Nagamasa, Ota, Ikuko, Yoshihara, Keisuke, Takahashi, Noriko
Format:	Journal Article
Language:	English
Published:	Cheshire Springer Healthcare 01.08.2022
Subjects:	Cardiology Endocrinology Internal Medicine Medicine Medicine & Public Health NCT NCT02475356 Oncology Original Research Pharmacology/Toxicology Rheumatology Heavy menstrual bleeding Japan Levonorgestrel-releasing intrauterine system Menorrhagia multi-attribute scale (MMAS) Patient-reported outcome Menstrual distress questionnaire (MDQ) Dysmenorrhea Quality of life
ISSN:	0741-238X, 1865-8652, 1865-8652
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Abstract	Introduction The present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who underwent insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg. We aimed to evaluate the quality of life (QOL) of Japanese women over the course of the investigational period. Methods This was a multicenter, non-interventional, prospective, single-cohort, post-marketing surveillance study (J-MIRAI). The primary outcome was the median change in the Menstrual Distress Questionnaire (MDQ) and Menorrhagia Multi-Attribute Scale (MMAS) scores from baseline to 3 and 12 months after LNG-IUS insertion, with decreasing and increasing scores, respectively, indicating improvement. The secondary outcomes were the statistical relationships between the MDQ and menstrual pain (measured by a visual analog scale, VAS), and between the MMAS and pictorial blood loss assessment chart (PBAC) scores by regression analysis. Results In total, 593 patients were evaluated; 376, 467, and 250 patients were diagnosed with dysmenorrhea, HMB, or both, respectively. The median MDQ score decreased significantly at 3 and 12 months after LNG-IUS insertion in both the premenstrual and menstrual periods (both p < 0.001 vs baseline), and the median MMAS score showed a similar improvement during the menstrual period. Changes in median MDQ and MMAS scores were observed regardless of patient background. Correlations between MDQ and menstrual pain (VAS) and between MMAS and PBAC scores were found (estimated regression coefficients 0.29 and − 0.15, respectively). Conclusion The LNG-IUS contributed to improvements in the QOL of patients with dysmenorrhea, HMB, and both, regardless of patient background characteristics. Trial Registration Registered at ClinicalTrials.gov (NCT02475356) on 18 June 2015.
AbstractList	The present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who underwent insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg. We aimed to evaluate the quality of life (QOL) of Japanese women over the course of the investigational period.INTRODUCTIONThe present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who underwent insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg. We aimed to evaluate the quality of life (QOL) of Japanese women over the course of the investigational period.This was a multicenter, non-interventional, prospective, single-cohort, post-marketing surveillance study (J-MIRAI). The primary outcome was the median change in the Menstrual Distress Questionnaire (MDQ) and Menorrhagia Multi-Attribute Scale (MMAS) scores from baseline to 3 and 12 months after LNG-IUS insertion, with decreasing and increasing scores, respectively, indicating improvement. The secondary outcomes were the statistical relationships between the MDQ and menstrual pain (measured by a visual analog scale, VAS), and between the MMAS and pictorial blood loss assessment chart (PBAC) scores by regression analysis.METHODSThis was a multicenter, non-interventional, prospective, single-cohort, post-marketing surveillance study (J-MIRAI). The primary outcome was the median change in the Menstrual Distress Questionnaire (MDQ) and Menorrhagia Multi-Attribute Scale (MMAS) scores from baseline to 3 and 12 months after LNG-IUS insertion, with decreasing and increasing scores, respectively, indicating improvement. The secondary outcomes were the statistical relationships between the MDQ and menstrual pain (measured by a visual analog scale, VAS), and between the MMAS and pictorial blood loss assessment chart (PBAC) scores by regression analysis.In total, 593 patients were evaluated; 376, 467, and 250 patients were diagnosed with dysmenorrhea, HMB, or both, respectively. The median MDQ score decreased significantly at 3 and 12 months after LNG-IUS insertion in both the premenstrual and menstrual periods (both p < 0.001 vs baseline), and the median MMAS score showed a similar improvement during the menstrual period. Changes in median MDQ and MMAS scores were observed regardless of patient background. Correlations between MDQ and menstrual pain (VAS) and between MMAS and PBAC scores were found (estimated regression coefficients 0.29 and - 0.15, respectively).RESULTSIn total, 593 patients were evaluated; 376, 467, and 250 patients were diagnosed with dysmenorrhea, HMB, or both, respectively. The median MDQ score decreased significantly at 3 and 12 months after LNG-IUS insertion in both the premenstrual and menstrual periods (both p < 0.001 vs baseline), and the median MMAS score showed a similar improvement during the menstrual period. Changes in median MDQ and MMAS scores were observed regardless of patient background. Correlations between MDQ and menstrual pain (VAS) and between MMAS and PBAC scores were found (estimated regression coefficients 0.29 and - 0.15, respectively).The LNG-IUS contributed to improvements in the QOL of patients with dysmenorrhea, HMB, and both, regardless of patient background characteristics.CONCLUSIONThe LNG-IUS contributed to improvements in the QOL of patients with dysmenorrhea, HMB, and both, regardless of patient background characteristics.Registered at ClinicalTrials.gov (NCT02475356) on 18 June 2015.TRIAL REGISTRATIONRegistered at ClinicalTrials.gov (NCT02475356) on 18 June 2015. The present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who underwent insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg. We aimed to evaluate the quality of life (QOL) of Japanese women over the course of the investigational period. This was a multicenter, non-interventional, prospective, single-cohort, post-marketing surveillance study (J-MIRAI). The primary outcome was the median change in the Menstrual Distress Questionnaire (MDQ) and Menorrhagia Multi-Attribute Scale (MMAS) scores from baseline to 3 and 12 months after LNG-IUS insertion, with decreasing and increasing scores, respectively, indicating improvement. The secondary outcomes were the statistical relationships between the MDQ and menstrual pain (measured by a visual analog scale, VAS), and between the MMAS and pictorial blood loss assessment chart (PBAC) scores by regression analysis. In total, 593 patients were evaluated; 376, 467, and 250 patients were diagnosed with dysmenorrhea, HMB, or both, respectively. The median MDQ score decreased significantly at 3 and 12 months after LNG-IUS insertion in both the premenstrual and menstrual periods (both p < 0.001 vs baseline), and the median MMAS score showed a similar improvement during the menstrual period. Changes in median MDQ and MMAS scores were observed regardless of patient background. Correlations between MDQ and menstrual pain (VAS) and between MMAS and PBAC scores were found (estimated regression coefficients 0.29 and - 0.15, respectively). The LNG-IUS contributed to improvements in the QOL of patients with dysmenorrhea, HMB, and both, regardless of patient background characteristics. Registered at ClinicalTrials.gov (NCT02475356) on 18 June 2015. Introduction The present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who underwent insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) 52 mg. We aimed to evaluate the quality of life (QOL) of Japanese women over the course of the investigational period. Methods This was a multicenter, non-interventional, prospective, single-cohort, post-marketing surveillance study (J-MIRAI). The primary outcome was the median change in the Menstrual Distress Questionnaire (MDQ) and Menorrhagia Multi-Attribute Scale (MMAS) scores from baseline to 3 and 12 months after LNG-IUS insertion, with decreasing and increasing scores, respectively, indicating improvement. The secondary outcomes were the statistical relationships between the MDQ and menstrual pain (measured by a visual analog scale, VAS), and between the MMAS and pictorial blood loss assessment chart (PBAC) scores by regression analysis. Results In total, 593 patients were evaluated; 376, 467, and 250 patients were diagnosed with dysmenorrhea, HMB, or both, respectively. The median MDQ score decreased significantly at 3 and 12 months after LNG-IUS insertion in both the premenstrual and menstrual periods (both p < 0.001 vs baseline), and the median MMAS score showed a similar improvement during the menstrual period. Changes in median MDQ and MMAS scores were observed regardless of patient background. Correlations between MDQ and menstrual pain (VAS) and between MMAS and PBAC scores were found (estimated regression coefficients 0.29 and − 0.15, respectively). Conclusion The LNG-IUS contributed to improvements in the QOL of patients with dysmenorrhea, HMB, and both, regardless of patient background characteristics. Trial Registration Registered at ClinicalTrials.gov (NCT02475356) on 18 June 2015.
Author	Akira, Shigeo Harada, Tasuku Kitawaki, Jo Ota, Ikuko Momoeda, Mikio Yoshihara, Keisuke Maeda, Nagamasa Takahashi, Noriko
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CitedBy_id	crossref_primary_10_1016_j_contraception_2022_08_006 crossref_primary_10_7759_cureus_49569 crossref_primary_10_3390_disabilities5020051
Cites_doi	10.1093/epirev/mxt009 10.4103/jfmpc.jfmpc_209_18 10.1093/humupd/dmv039 10.1016/j.ajog.2020.08.016 10.1016/0885-3924(96)00128-5 10.1111/hae.12886 10.1007/s00404-011-1902-1 10.2147/IJWH.S99705 10.1017/S0033291700009934 10.1016/j.ijgo.2014.09.027 10.3109/07853899009147248 10.1016/S0091-2182(99)00029-4 10.1007/s00404-011-1937-3 10.1097/00000542-200112000-00013 10.2147/IJWH.S238460 10.1111/jog.14487 10.1136/ard.38.6.560 10.1089/jwh.2018.7615 10.3111/13696998.2013.830974 10.1136/ard.37.4.378 10.3109/03009730903457218 10.1080/ejc.6.4.192.198 10.1016/S0049-3848(17)30072-5 10.1186/s40834-017-0047-4 10.1016/j.ijgo.2004.09.004 10.1186/s12905-018-0533-0 10.1056/NEJMoa1204724 10.1111/j.1471-0528.1990.tb16249.x 10.1007/s12325-020-01564-y 10.1002/14651858.CD002126.pub4
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Keywords	Heavy menstrual bleeding Japan Levonorgestrel-releasing intrauterine system Menorrhagia multi-attribute scale (MMAS) Patient-reported outcome Menstrual distress questionnaire (MDQ) Dysmenorrhea Quality of life
Language	English
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References	Ju, Jones, Mishra (CR3) 2014; 36 Akiyama, Kayasima (CR23) 1979; 5 Kawaguchi, Matsumoto, Ishikawa (CR9) 2021; 47 Unsal, Ayranci, Tozun, Arslan, Calik (CR16) 2010; 115 Momoeda, Tanaka, Kawaguchi (CR24) 2015; 82 Luukkainen, Lähteenmäki, Toivonen (CR18) 1990; 22 (CR10) 2018 Scott, Huskisson (CR26) 1979; 38 Gaston-Johansson (CR28) 1996; 12 CR37 CR13 Sriprasert, Pakrashi, Kimble, Archer (CR1) 2017; 2 CR33 Fraser, Mansour, Breymann, Hoffman, Mezzacasa, Petraglia (CR4) 2015; 128 Costanzi, De Marco, Colombrino (CR39) 2021; 25 Halimeh, Rott, Kappert (CR30) 2016; 22 Davies, Kadir (CR11) 2017; 151 Gupta, Kai, Middleton, Pattison, Gray, Daniels (CR36) 2013; 368 Armour, Parry, Manohar (CR2) 2019; 28 Rodrigues, Gala, Neves (CR17) 2011; 24 McCormack, Horne, Sheather (CR27) 1988; 18 Costescu (CR19) 2016; 8 Ikeda, Shiroiwa, Igarashi (CR32) 2015; 64 Tanaka, Momoeda, Osuga (CR5) 2013; 16 Bodian, Freedman, Hossain, Eisenkraft, Beilin (CR29) 2001; 95 Osuga, Hayashi, Kobayashi (CR8) 2005; 88 Beelen, van den Brink, Herman (CR41) 2021; 224 CR7 Endrikat, Vilos, Muysers, Fortier, Solomayer, Lukkari-Lax (CR21) 2012; 285 CR22 Higham, O’Brien, Shaw (CR31) 1990; 97 Laksham, Selvaraj, Kar (CR14) 2019; 8 CR20 Iacovides, Avidon, Baker (CR6) 2015; 21 Engstrom, Rose, Brill, Polhill, Lukanich, Fritz (CR15) 1999; 44 Momoeda, Akiyama, Tanaka, Suzukamo (CR34) 2020; 12 Yoo, Lee, Ko, Yang, Kang, Lee (CR40) 2012; 285 Wildemeersch, Schacht, Wildemeersch (CR38) 2001; 6 Lu, Yang (CR42) 2018; 18 Xu, Lee, Asif, Kraemer, Inki (CR35) 2014; 6 Mansour, Hofmann, Gemzell-Danielsson (CR12) 2021; 38 Downie, Leatham, Rhind, Wright, Branco, Anderson (CR25) 1978; 37 Y Osuga (2205_CR8) 2005; 88 I Sriprasert (2205_CR1) 2017; 2 S Iacovides (2205_CR6) 2015; 21 P Beelen (2205_CR41) 2021; 224 2205_CR37 2205_CR13 S Ikeda (2205_CR32) 2015; 64 DJ Costescu (2205_CR19) 2016; 8 R Kawaguchi (2205_CR9) 2021; 47 2205_CR33 L Xu (2205_CR35) 2014; 6 HM McCormack (2205_CR27) 1988; 18 J Gupta (2205_CR36) 2013; 368 HJ Yoo (2205_CR40) 2012; 285 T Luukkainen (2205_CR18) 1990; 22 H Ju (2205_CR3) 2014; 36 IS Fraser (2205_CR4) 2015; 128 F Costanzi (2205_CR39) 2021; 25 J Davies (2205_CR11) 2017; 151 AC Rodrigues (2205_CR17) 2011; 24 A Unsal (2205_CR16) 2010; 115 2205_CR7 M Armour (2205_CR2) 2019; 28 D Mansour (2205_CR12) 2021; 38 2205_CR22 2205_CR20 J Endrikat (2205_CR21) 2012; 285 CA Bodian (2205_CR29) 2001; 95 M Lu (2205_CR42) 2018; 18 JL Engstrom (2205_CR15) 1999; 44 WW Downie (2205_CR25) 1978; 37 E Tanaka (2205_CR5) 2013; 16 Japan Society of Obstetrics and Gynecology (2205_CR10) 2018 M Momoeda (2205_CR24) 2015; 82 S Halimeh (2205_CR30) 2016; 22 M Momoeda (2205_CR34) 2020; 12 KB Laksham (2205_CR14) 2019; 8 A Akiyama (2205_CR23) 1979; 5 J Scott (2205_CR26) 1979; 38 F Gaston-Johansson (2205_CR28) 1996; 12 JM Higham (2205_CR31) 1990; 97 D Wildemeersch (2205_CR38) 2001; 6
References_xml	– volume: 36 start-page: 104 year: 2014 end-page: 113 ident: CR3 article-title: The prevalence and risk factors of dysmenorrhea publication-title: Epidemiol Rev doi: 10.1093/epirev/mxt009 – ident: CR22 – volume: 8 start-page: 137 year: 2019 end-page: 140 ident: CR14 article-title: Menstrual disorders and quality of life of women in an urban area of Puducherry: a community-based cross-sectional study publication-title: J Family Med Prim Care doi: 10.4103/jfmpc.jfmpc_209_18 – volume: 21 start-page: 762 year: 2015 end-page: 778 ident: CR6 article-title: What we know about primary dysmenorrhea today: a critical review publication-title: Hum Reprod Update doi: 10.1093/humupd/dmv039 – volume: 224 start-page: 187.e1 year: 2021 end-page: 187.e10 ident: CR41 article-title: Levonorgestrel-releasing intrauterine system versus endometrial ablation for heavy menstrual bleeding publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2020.08.016 – volume: 12 start-page: 172 year: 1996 end-page: 181 ident: CR28 article-title: Measurement of pain: the psychometric properties of the Pain-O-Meter, a simple, inexpensive pain assessment tool that could change health care practices publication-title: J Pain Symptom Manage doi: 10.1016/0885-3924(96)00128-5 – volume: 22 start-page: e217 year: 2016 end-page: e220 ident: CR30 article-title: PBAC score: an easy-to-use tool to predict coagulation disorders in women with idiopathic heavy menstrual bleeding publication-title: Haemophilia doi: 10.1111/hae.12886 – ident: CR37 – year: 2018 ident: CR10 publication-title: Obstetrics and gynecology glossary – ident: CR33 – volume: 285 start-page: 117 year: 2012 end-page: 121 ident: CR21 article-title: The levonorgestrel-releasing intrauterine system provides a reliable, long-term treatment option for women with idiopathic menorrhagia publication-title: Arch Gynecol Obstet doi: 10.1007/s00404-011-1902-1 – volume: 8 start-page: 589 year: 2016 end-page: 598 ident: CR19 article-title: Levonorgestrel-releasing intrauterine systems for long-acting contraception: current perspectives, safety, and patient counseling publication-title: Int J Womens Health doi: 10.2147/IJWH.S99705 – volume: 24 start-page: 383 year: 2011 end-page: 388 ident: CR17 article-title: Dismenorreia em adolescentes e jovens adultas: prevalência, factores associados e limitações na vida diária [Dysmenorrhea in adolescents and young adults: prevalence, related factors and limitations in daily living] publication-title: Acta Med Port – volume: 18 start-page: 1007 year: 1988 end-page: 1019 ident: CR27 article-title: Clinical applications of visual analogue scales: a critical review publication-title: Psychol Med doi: 10.1017/S0033291700009934 – volume: 128 start-page: 196 year: 2015 end-page: 200 ident: CR4 article-title: Prevalence of heavy menstrual bleeding and experiences of affected women in a European patient survey publication-title: Int J Gynaecol Obstet doi: 10.1016/j.ijgo.2014.09.027 – volume: 22 start-page: 85 year: 1990 end-page: 90 ident: CR18 article-title: Levonorgestrel-releasing intrauterine device publication-title: Ann Med doi: 10.3109/07853899009147248 – volume: 44 start-page: 89 year: 1999 end-page: 105 ident: CR15 article-title: Midwifery care of the woman with menorrhagia publication-title: J Nurse Midwifery doi: 10.1016/S0091-2182(99)00029-4 – volume: 25 start-page: 3432 year: 2021 end-page: 3439 ident: CR39 article-title: The treatment with Levonorgestrel Releasing Intrauterine System (LNG-IUS) in patients affected by menometrorrhagia, dysmenorrhea and adenomimyois: clinical and ultrasonographic reports publication-title: Eur Rev Med Pharmacol Sci – volume: 285 start-page: 161 year: 2012 end-page: 166 ident: CR40 article-title: The efficacy of the levonorgestrel-releasing intrauterine system in perimenopausal women with menorrhagia or dysmenorrhea publication-title: Arch Gynecol Obstet doi: 10.1007/s00404-011-1937-3 – volume: 95 start-page: 1356 year: 2001 end-page: 1361 ident: CR29 article-title: The visual analog scale for pain: clinical significance in postoperative patients publication-title: Anesthesiology doi: 10.1097/00000542-200112000-00013 – volume: 12 start-page: 327 year: 2020 end-page: 338 ident: CR34 article-title: Quality of life in Japanese patients with dysmenorrhea treated with ethinylestradiol 20 μg/drospirenone 3 mg in a real-world setting: An observational study publication-title: Int J Womens Health doi: 10.2147/IJWH.S238460 – volume: 47 start-page: 5 year: 2021 end-page: 25 ident: CR9 article-title: Guideline for gynecological practice in Japan: Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists 2020 edition publication-title: J Obstet Gynaecol Res doi: 10.1111/jog.14487 – volume: 38 start-page: 560 year: 1979 ident: CR26 article-title: Vertical or horizontal visual analogue scales publication-title: Ann Rheum Dis doi: 10.1136/ard.38.6.560 – volume: 28 start-page: 1161 year: 2019 end-page: 1171 ident: CR2 article-title: The prevalence and academic impact of dysmenorrhea in 21,573 young women: a systematic review and meta-analysis publication-title: J Womens Health (Larchmt) doi: 10.1089/jwh.2018.7615 – volume: 16 start-page: 1255 year: 2013 end-page: 1266 ident: CR5 article-title: Burden of menstrual symptoms in Japanese women: results from a survey-based study publication-title: J Med Econ doi: 10.3111/13696998.2013.830974 – volume: 37 start-page: 378 year: 1978 end-page: 381 ident: CR25 article-title: Studies with pain rating scales publication-title: Ann Rheum Dis doi: 10.1136/ard.37.4.378 – volume: 115 start-page: 138 year: 2010 end-page: 145 ident: CR16 article-title: Prevalence of dysmenorrhea and its effect on quality of life among a group of female university students publication-title: Ups J Med Sci doi: 10.3109/03009730903457218 – volume: 6 start-page: 192 year: 2001 end-page: 198 ident: CR38 article-title: Treatment of primary and secondary dysmenorrhea with a novel 'frameless' intrauterine levonorgestrel-releasing drug delivery system: a pilot study publication-title: Eur J Contracept Reprod Health Care doi: 10.1080/ejc.6.4.192.198 – volume: 151 start-page: S70 year: 2017 end-page: S77 ident: CR11 article-title: Heavy menstrual bleeding: an update on management publication-title: Thromb Res doi: 10.1016/S0049-3848(17)30072-5 – volume: 2 start-page: 20 year: 2017 ident: CR1 article-title: Heavy menstrual bleeding diagnosis and medical management publication-title: Contracept Reprod Med doi: 10.1186/s40834-017-0047-4 – volume: 6 start-page: 547 year: 2014 end-page: 554 ident: CR35 article-title: Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy publication-title: Int J Womens Health – ident: CR13 – volume: 5 start-page: 272 year: 1979 end-page: 277 ident: CR23 article-title: The Japanese version of Menstrual Distress questionnaire publication-title: Nurs Psychol – volume: 88 start-page: 82 year: 2005 end-page: 83 ident: CR8 article-title: Dysmenorrhea in Japanese women publication-title: Int J Gynaecol Obstet doi: 10.1016/j.ijgo.2004.09.004 – volume: 18 start-page: 45 year: 2018 ident: CR42 article-title: Levonorgestrel-releasing intrauterine system for treatment of heavy menstrual bleeding in adolescents with Glanzmann's Thrombasthenia: illustrated case series publication-title: BMC Womens Health doi: 10.1186/s12905-018-0533-0 – ident: CR7 – volume: 82 start-page: 1299 year: 2015 end-page: 1305 ident: CR24 article-title: Development of the Japanese version of the Menorrhagia Multi-Attribute Scale (MMAS): translation and linguistic validation publication-title: Sanka Fujinka [Obstetrics and Gynecology] – volume: 64 start-page: 47 year: 2015 end-page: 55 ident: CR32 article-title: Developing a Japanese version of the EQ-5D-5L value set publication-title: J Natl Inst Public Health – volume: 368 start-page: 128 year: 2013 end-page: 137 ident: CR36 article-title: Levonorgestrel intrauterine system versus medical therapy for menorrhagia publication-title: N Engl J Med doi: 10.1056/NEJMoa1204724 – ident: CR20 – volume: 97 start-page: 734 year: 1990 end-page: 739 ident: CR31 article-title: Assessment of menstrual blood loss using a pictorial chart publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1990.tb16249.x – volume: 38 start-page: 201 year: 2021 end-page: 225 ident: CR12 article-title: A review of clinical guidelines on the management of iron deficiency and iron-deficiency anemia in women with heavy menstrual bleeding publication-title: Adv Ther doi: 10.1007/s12325-020-01564-y – volume: 95 start-page: 1356 year: 2001 ident: 2205_CR29 publication-title: Anesthesiology doi: 10.1097/00000542-200112000-00013 – ident: 2205_CR22 – volume: 18 start-page: 1007 year: 1988 ident: 2205_CR27 publication-title: Psychol Med doi: 10.1017/S0033291700009934 – volume: 6 start-page: 547 year: 2014 ident: 2205_CR35 publication-title: Int J Womens Health – volume: 38 start-page: 560 year: 1979 ident: 2205_CR26 publication-title: Ann Rheum Dis doi: 10.1136/ard.38.6.560 – ident: 2205_CR20 – volume: 22 start-page: e217 year: 2016 ident: 2205_CR30 publication-title: Haemophilia doi: 10.1111/hae.12886 – volume: 285 start-page: 161 year: 2012 ident: 2205_CR40 publication-title: Arch Gynecol Obstet doi: 10.1007/s00404-011-1937-3 – volume: 6 start-page: 192 year: 2001 ident: 2205_CR38 publication-title: Eur J Contracept Reprod Health Care doi: 10.1080/ejc.6.4.192.198 – ident: 2205_CR13 – volume: 2 start-page: 20 year: 2017 ident: 2205_CR1 publication-title: Contracept Reprod Med doi: 10.1186/s40834-017-0047-4 – volume: 12 start-page: 327 year: 2020 ident: 2205_CR34 publication-title: Int J Womens Health doi: 10.2147/IJWH.S238460 – volume: 151 start-page: S70 year: 2017 ident: 2205_CR11 publication-title: Thromb Res doi: 10.1016/S0049-3848(17)30072-5 – volume-title: Obstetrics and gynecology glossary year: 2018 ident: 2205_CR10 – ident: 2205_CR7 – volume: 128 start-page: 196 year: 2015 ident: 2205_CR4 publication-title: Int J Gynaecol Obstet doi: 10.1016/j.ijgo.2014.09.027 – volume: 5 start-page: 272 year: 1979 ident: 2205_CR23 publication-title: Nurs Psychol – volume: 368 start-page: 128 year: 2013 ident: 2205_CR36 publication-title: N Engl J Med doi: 10.1056/NEJMoa1204724 – volume: 115 start-page: 138 year: 2010 ident: 2205_CR16 publication-title: Ups J Med Sci doi: 10.3109/03009730903457218 – volume: 82 start-page: 1299 year: 2015 ident: 2205_CR24 publication-title: Sanka Fujinka [Obstetrics and Gynecology] – volume: 16 start-page: 1255 year: 2013 ident: 2205_CR5 publication-title: J Med Econ doi: 10.3111/13696998.2013.830974 – volume: 25 start-page: 3432 year: 2021 ident: 2205_CR39 publication-title: Eur Rev Med Pharmacol Sci – volume: 8 start-page: 589 year: 2016 ident: 2205_CR19 publication-title: Int J Womens Health doi: 10.2147/IJWH.S99705 – volume: 12 start-page: 172 year: 1996 ident: 2205_CR28 publication-title: J Pain Symptom Manage doi: 10.1016/0885-3924(96)00128-5 – volume: 64 start-page: 47 year: 2015 ident: 2205_CR32 publication-title: J Natl Inst Public Health – volume: 38 start-page: 201 year: 2021 ident: 2205_CR12 publication-title: Adv Ther doi: 10.1007/s12325-020-01564-y – ident: 2205_CR37 doi: 10.1002/14651858.CD002126.pub4 – volume: 22 start-page: 85 year: 1990 ident: 2205_CR18 publication-title: Ann Med doi: 10.3109/07853899009147248 – volume: 47 start-page: 5 year: 2021 ident: 2205_CR9 publication-title: J Obstet Gynaecol Res doi: 10.1111/jog.14487 – volume: 285 start-page: 117 year: 2012 ident: 2205_CR21 publication-title: Arch Gynecol Obstet doi: 10.1007/s00404-011-1902-1 – volume: 24 start-page: 383 year: 2011 ident: 2205_CR17 publication-title: Acta Med Port – volume: 88 start-page: 82 year: 2005 ident: 2205_CR8 publication-title: Int J Gynaecol Obstet doi: 10.1016/j.ijgo.2004.09.004 – volume: 44 start-page: 89 year: 1999 ident: 2205_CR15 publication-title: J Nurse Midwifery doi: 10.1016/S0091-2182(99)00029-4 – volume: 28 start-page: 1161 year: 2019 ident: 2205_CR2 publication-title: J Womens Health (Larchmt) doi: 10.1089/jwh.2018.7615 – volume: 97 start-page: 734 year: 1990 ident: 2205_CR31 publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1990.tb16249.x – ident: 2205_CR33 – volume: 224 start-page: 187.e1 year: 2021 ident: 2205_CR41 publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2020.08.016 – volume: 21 start-page: 762 year: 2015 ident: 2205_CR6 publication-title: Hum Reprod Update doi: 10.1093/humupd/dmv039 – volume: 37 start-page: 378 year: 1978 ident: 2205_CR25 publication-title: Ann Rheum Dis doi: 10.1136/ard.37.4.378 – volume: 18 start-page: 45 year: 2018 ident: 2205_CR42 publication-title: BMC Womens Health doi: 10.1186/s12905-018-0533-0 – volume: 36 start-page: 104 year: 2014 ident: 2205_CR3 publication-title: Epidemiol Rev doi: 10.1093/epirev/mxt009 – volume: 8 start-page: 137 year: 2019 ident: 2205_CR14 publication-title: J Family Med Prim Care doi: 10.4103/jfmpc.jfmpc_209_18
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Snippet	Introduction The present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding... The present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who...
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SubjectTerms	Cardiology Endocrinology Internal Medicine Medicine Medicine & Public Health NCT NCT02475356 Oncology Original Research Pharmacology/Toxicology Rheumatology
Title	Quality of Life of Japanese Dysmenorrhea/Heavy Menstrual Bleeding Patients Treated with Levonorgestrel Intrauterine Delivery System in a Real-World Setting
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