Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution

Gene silencing is essential for regulating cell fate in eukaryotes. Altered chromatin architectures contribute to maintaining the silenced state in a variety of species. The silent information regulator (Sir) proteins regulate mating type in Saccharomyces cerevisiae. One of these proteins, Sir3, int...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 334; no. 6058; p. 977
Main Authors:	Armache, Karim-Jean, Garlick, Joseph D, Canzio, Daniele, Narlikar, Geeta J, Kingston, Robert E
Format:	Journal Article
Language:	English
Published:	United States 18.11.2011
Subjects:	Acetylation Amino Acid Sequence Binding Sites Chemical Phenomena Crystallography, X-Ray Gene Silencing Histones - chemistry Histones - metabolism Hydrogen Bonding Methylation Models, Molecular Molecular Sequence Data Mutagenesis Mutant Proteins - chemistry Mutant Proteins - metabolism Nucleosomes - chemistry Nucleosomes - metabolism Nucleosomes - ultrastructure Protein Folding Protein Interaction Domains and Motifs Protein Multimerization Protein Structure, Tertiary Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Silent Information Regulator Proteins, Saccharomyces cerevisiae - chemistry Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Static Electricity
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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