Investigation of PVA cryogel Young’s modulus stability with time, controlled by a simple reliable technique

We describe a quasistatic method for mechanical characterization of tissue-mimicking material used in elastography. We demonstrate that it is possible to assess the elasticity modulus with a reasonable reproducibility using simple and easy tools and methods. Possessing a simple relevant technique wi...

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Bibliographic Details
Published in:Medical physics (Lancaster) Vol. 36; no. 2; pp. 656 - 661
Main Authors: Duboeuf, François, Basarab, Adrian, Liebgott, Hervé, Brusseau, Elisabeth, Delachartre, Philippe, Vray, Didier
Format: Journal Article
Language:English
Published: United States American Association of Physicists in Medicine 01.02.2009
Subjects:
biological tissues
biomedical ultrasonics
Biomimetics
Costs and Cost Analysis
Elastic moduli
Elasticity
Elasticity and anelasticity, stress‐strain relations
Gels
Gels and sols
Liver
Magnetic Resonance Imaging
Mechanical properties
Medical diagnosis with acoustics
Medical imaging
melting
phantoms
Phantoms, Imaging - economics
polymer gels
Polyvinyl Alcohol - chemistry
Reproducibility of Results
Shear deformation
Temperature
Time Factors
Tissues
Ultrasonics
Ultrasonographic imaging
Ultrasonography
Young's modulus
ISSN:0094-2405, 2473-4209
Online Access:Get full text
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Summary:We describe a quasistatic method for mechanical characterization of tissue-mimicking material used in elastography. We demonstrate that it is possible to assess the elasticity modulus with a reasonable reproducibility using simple and easy tools and methods. Possessing a simple relevant technique with evaluated relative error to assess Young’s modulus of these phantoms could deeply improve the quality of the research in the field of elastography. The method was tested and validated with four samples of polyvinyl alcohol (PVA) cryogel with different elasticity values corresponding to those of stiffer soft biological tissues. Young’s moduli, varying from 70 to 180 kPa depending on the number of freeze-thaw cycles (two to five), were measured within strict measurement conditions and found to have a reproducibility varying from 4% to 8%. Relative error, estimated as the ratio between observed and reference values, varied from 16% to 32%. Besides, measurement stability over 4 months was evaluated. The method demonstrated good feasibility and acceptable reproducibility for mechanically characterizing and controlled over time phantoms used for validating new potential ultrasound imaging techniques in the field of elastography. Nevertheless, in this study, investigation was performed on gel possessing young’s modulus values ranging from 80 to 215 kPa . Some tissue values of Young’modulus were reported to be lower, ranging from 0.6 to 28 kPa as liver or glandular values. Consequently, further validation of this static method for mechanical characterization of phantom gels should be performed using softer PVA cryogel.
Bibliography:duboeuf.francois@creatis.insa-lyon.fr
Electronic mail
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ISSN:0094-2405
2473-4209
DOI:10.1118/1.3065031