Primary Sclerosing Cholangitis
This review summarizes the current understanding of primary sclerosing cholangitis, a persistent, progressive disease for which there is no definitive therapy. The authors describe the pathogenesis and management of this condition. Primary sclerosing cholangitis is an idiopathic, heterogeneous, chol...
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| Vydáno v: | The New England journal of medicine Ročník 375; číslo 12; s. 1161 - 1170 |
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| Hlavní autoři: | , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Massachusetts Medical Society
22.09.2016
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| Témata: | |
| ISSN: | 0028-4793, 1533-4406, 1533-4406 |
| On-line přístup: | Získat plný text |
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| Shrnutí: | This review summarizes the current understanding of primary sclerosing cholangitis, a persistent, progressive disease for which there is no definitive therapy. The authors describe the pathogenesis and management of this condition.
Primary sclerosing cholangitis is an idiopathic, heterogeneous, cholestatic liver disease that is characterized by persistent, progressive, biliary inflammation and fibrosis. There is no effective medical therapy for this condition.
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End-stage liver disease necessitating liver transplantation may ultimately develop in affected patients.
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The cause and pathogenesis of primary sclerosing cholangitis are unclear, although it is generally accepted that both genetic and environmental risk factors contribute to the development of the disease as well as to its progression and outcomes.
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Primary sclerosing cholangitis is strongly associated with inflammatory bowel disease (70 to 80% of patients have both conditions), and it is a . . . |
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| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0028-4793 1533-4406 1533-4406 |
| DOI: | 10.1056/NEJMra1506330 |