Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis

For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now permit randomized, controlled trials of shortened-duration, all-oral treatments for rifampin-resistant t...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 392; no. 5; pp. 468 - 482
Main Authors:	Guglielmetti, Lorenzo, Khan, Uzma, Velásquez, Gustavo E., Gouillou, Maelenn, Abubakirov, Amanzhan, Baudin, Elisabeth, Berikova, Elmira, Berry, Catherine, Bonnet, Maryline, Cellamare, Matteo, Chavan, Vijay, Cox, Vivian, Dakenova, Zhanna, de Jong, Bouke Catherine, Ferlazzo, Gabriella, Karabayev, Aydarkhan, Kirakosyan, Ohanna, Kiria, Nana, Kunda, Mikanda, Lachenal, Nathalie, Lecca, Leonid, McIlleron, Helen, Motta, Ilaria, Toscano, Sergio Mucching, Mushtaque, Hebah, Nahid, Payam, Oyewusi, Lawrence, Panda, Samiran, Patil, Sandip, Phillips, Patrick P. J., Ruiz, Jimena, Salahuddin, Naseem, Garavito, Epifanio Sanchez, Seung, Kwonjune J., Ticona, Eduardo, Trippa, Lorenzo, Vasquez, Dante E. Vargas, Wasserman, Sean, Rich, Michael L., Varaine, Francis, Mitnick, Carole D.
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 30.01.2025
Subjects:	Administration, Oral Adolescent Adult Aged Antibiotics Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Bayes Theorem Bayesian analysis Clinical trials Clofazimine Drug Administration Schedule Drug dosages Drug Resistance, Bacterial Drug Therapy, Combination - adverse effects Drug Therapy, Combination - methods Female Fluoroquinolones - pharmacology Fluoroquinolones - therapeutic use Global Health Humans Infectious Disease Infectious Disease General Intention to Treat Analysis Levofloxacin Linezolid Lung - diagnostic imaging Lung - microbiology Male Middle Aged Moxifloxacin Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Patients Pharmacovigilance Pyrazinamide Rifampin Rifampin - pharmacology Rifampin - therapeutic use Sputum Sputum - microbiology Time Factors Treatment Outcome Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology Young Adult South Africa
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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