Klebsiella pneumoniae producing bacterial toxin colibactin as a risk of colorectal cancer development - A systematic review

Microbiota can significantly contribute to colorectal cancer initiation and development. It was described that E. coli harbouring polyketide synthase (pks) genes can synthetize bacterial toxin colibactin, which was first described by Nougayrede's group in 2006. E. coli positive for pks genes we...

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Bibliographic Details
Published in:	Toxicon (Oxford) Vol. 197; pp. 126 - 135
Main Authors:	Strakova, Nicol, Korena, Kristyna, Karpiskova, Renata
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15.07.2021
Subjects:	adhesins Bacterial Toxins biomarkers cancer therapy Cancer-distinctive microbiota carcinogenesis Colibactin Colon colorectal neoplasms Colorectal Neoplasms - chemically induced digestive system DNA damage endotoxins Escherichia coli Humans Klebsiella pneumoniae loci meningitis microbiome multigene family Peptides polyketide synthases Polyketides - toxicity risk factors sequence analysis siderophores systematic review virulence ks Colon Cancer-distinctive microbiota Colibactin DNA damage Klebsiella pneumoniae
ISSN:	0041-0101, 1879-3150, 1879-3150
Online Access:	Get full text
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