PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

It is unclear whether PD-L1 on tumor cells is sufficient for tumor immune evasion or simply correlates with an inflamed tumor microenvironment. We used three mouse tumor models sensitive to PD-1 blockade to evaluate the significance of PD-L1 on tumor versus nontumor cells. PD-L1 on nontumor cells is...

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Vydané v:	The Journal of experimental medicine Ročník 214; číslo 4; s. 895 - 904
Hlavní autori:	Juneja, Vikram R, McGuire, Kathleen A, Manguso, Robert T, LaFleur, Martin W, Collins, Natalie, Haining, W Nicholas, Freeman, Gordon J, Sharpe, Arlene H
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 03.04.2017
Predmet:	Animals B7-H1 Antigen - physiology CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Colorectal Neoplasms - immunology Cytotoxicity, Immunologic Lymphocyte Activation Melanoma - immunology Mice Mice, Inbred C57BL Programmed Cell Death 1 Receptor - physiology Tumor Escape Tumor Microenvironment
ISSN:	1540-9538
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