Supramolecular hydrogels based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties

•A cellulose-chalcone hydrogel containing carbon nanotubes was successfully developed.•The hydrogel was characterized by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM.•The hydrogel allows the sustained release of simultaneous therapeutic substances.•Linezolid is more effecti...

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Published in:	Carbohydrate polymers Vol. 242; p. 116383
Main Authors:	Forero-Doria, Oscar, Polo, Efrain, Marican, Adolfo, Guzmán, Luis, Venegas, Bernardo, Vijayakumar, Sekar, Wehinger, Sergio, Guerrero, Marcelo, Gallego, Jaime, Durán-Lara, Esteban F.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15.08.2020
Subjects:	allantoin Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity bioactive compounds carbon nanotubes Cell Line Cellulose Cellulose - chemistry Cellulose - pharmacology chalcone chromatography crosslinking Drug Liberation drugs Enterococcus faecium - drug effects Fourier transform infrared spectroscopy Hydrogel hydrogels Hydrogels - chemistry Hydrogels - pharmacology Kinetics linezolid Macromolecular Substances - chemistry Macromolecular Substances - pharmacology Mice Microbial Sensitivity Tests Molecular Structure Nanotube Particle Size Rats Rats, Sprague-Dawley resveratrol scanning electron microscopy Spectroscopy, Fourier Transform Infrared Surface Properties Sustained release Temperature therapeutics thermogravimetry tissue repair Wound healing Wound Healing - drug effects Sustained release Antibacterial activity Wound healing Hydrogel Cellulose Nanotube
ISSN:	0144-8617, 1879-1344, 1879-1344
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Abstract	•A cellulose-chalcone hydrogel containing carbon nanotubes was successfully developed.•The hydrogel was characterized by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM.•The hydrogel allows the sustained release of simultaneous therapeutic substances.•Linezolid is more effective when it is sustained-released from the hydrogel. A multifaceted hydrogel-based formulation was reported. The hydrogel was prepared by crosslinking cellulose and substituted chalcone. Moreover, the formulation was conjugated with carbon nanotubes with the aim of increasing the loading amount of bioactive compounds such as allantoin, dexpanthenol, resveratrol and linezolid. The hydrogel formation was confirmed by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM. The hydrogel showed an improved release rate of therapeutic substances, exhibiting a simultaneous and coordinated release according to the chromatographic studies. The efficacy of drug release was confirmed by wound closure and in vivo wound healing studies that showed promising healing results. The antibacterial assays demonstrated that the sustained release of linezolid tends to be very effective. In conclusion, a multifaceted formulation based on carbon nanotube-containing cellulose-chalcone was developed that can potentially be utilized in treating complex wounds owing to its improved wound healing properties and prevention of potential infections.
AbstractList	A multifaceted hydrogel-based formulation was reported. The hydrogel was prepared by crosslinking cellulose and substituted chalcone. Moreover, the formulation was conjugated with carbon nanotubes with the aim of increasing the loading amount of bioactive compounds such as allantoin, dexpanthenol, resveratrol and linezolid. The hydrogel formation was confirmed by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM. The hydrogel showed an improved release rate of therapeutic substances, exhibiting a simultaneous and coordinated release according to the chromatographic studies. The efficacy of drug release was confirmed by wound closure and in vivo wound healing studies that showed promising healing results. The antibacterial assays demonstrated that the sustained release of linezolid tends to be very effective. In conclusion, a multifaceted formulation based on carbon nanotube-containing cellulose-chalcone was developed that can potentially be utilized in treating complex wounds owing to its improved wound healing properties and prevention of potential infections. •A cellulose-chalcone hydrogel containing carbon nanotubes was successfully developed.•The hydrogel was characterized by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM.•The hydrogel allows the sustained release of simultaneous therapeutic substances.•Linezolid is more effective when it is sustained-released from the hydrogel. A multifaceted hydrogel-based formulation was reported. The hydrogel was prepared by crosslinking cellulose and substituted chalcone. Moreover, the formulation was conjugated with carbon nanotubes with the aim of increasing the loading amount of bioactive compounds such as allantoin, dexpanthenol, resveratrol and linezolid. The hydrogel formation was confirmed by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM. The hydrogel showed an improved release rate of therapeutic substances, exhibiting a simultaneous and coordinated release according to the chromatographic studies. The efficacy of drug release was confirmed by wound closure and in vivo wound healing studies that showed promising healing results. The antibacterial assays demonstrated that the sustained release of linezolid tends to be very effective. In conclusion, a multifaceted formulation based on carbon nanotube-containing cellulose-chalcone was developed that can potentially be utilized in treating complex wounds owing to its improved wound healing properties and prevention of potential infections. A multifaceted hydrogel-based formulation was reported. The hydrogel was prepared by crosslinking cellulose and substituted chalcone. Moreover, the formulation was conjugated with carbon nanotubes with the aim of increasing the loading amount of bioactive compounds such as allantoin, dexpanthenol, resveratrol and linezolid. The hydrogel formation was confirmed by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM. The hydrogel showed an improved release rate of therapeutic substances, exhibiting a simultaneous and coordinated release according to the chromatographic studies. The efficacy of drug release was confirmed by wound closure and in vivo wound healing studies that showed promising healing results. The antibacterial assays demonstrated that the sustained release of linezolid tends to be very effective. In conclusion, a multifaceted formulation based on carbon nanotube-containing cellulose-chalcone was developed that can potentially be utilized in treating complex wounds owing to its improved wound healing properties and prevention of potential infections.A multifaceted hydrogel-based formulation was reported. The hydrogel was prepared by crosslinking cellulose and substituted chalcone. Moreover, the formulation was conjugated with carbon nanotubes with the aim of increasing the loading amount of bioactive compounds such as allantoin, dexpanthenol, resveratrol and linezolid. The hydrogel formation was confirmed by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM. The hydrogel showed an improved release rate of therapeutic substances, exhibiting a simultaneous and coordinated release according to the chromatographic studies. The efficacy of drug release was confirmed by wound closure and in vivo wound healing studies that showed promising healing results. The antibacterial assays demonstrated that the sustained release of linezolid tends to be very effective. In conclusion, a multifaceted formulation based on carbon nanotube-containing cellulose-chalcone was developed that can potentially be utilized in treating complex wounds owing to its improved wound healing properties and prevention of potential infections.
ArticleNumber	116383
Author	Durán-Lara, Esteban F. Marican, Adolfo Guzmán, Luis Polo, Efrain Vijayakumar, Sekar Guerrero, Marcelo Gallego, Jaime Wehinger, Sergio Forero-Doria, Oscar Venegas, Bernardo
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Keywords	Sustained release Antibacterial activity Wound healing Hydrogel Cellulose Nanotube
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Snippet	•A cellulose-chalcone hydrogel containing carbon nanotubes was successfully developed.•The hydrogel was characterized by swelling tests, FT-IR spectroscopy,... A multifaceted hydrogel-based formulation was reported. The hydrogel was prepared by crosslinking cellulose and substituted chalcone. Moreover, the formulation...
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SubjectTerms	allantoin Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity bioactive compounds carbon nanotubes Cell Line Cellulose Cellulose - chemistry Cellulose - pharmacology chalcone chromatography crosslinking Drug Liberation drugs Enterococcus faecium - drug effects Fourier transform infrared spectroscopy Hydrogel hydrogels Hydrogels - chemistry Hydrogels - pharmacology Kinetics linezolid Macromolecular Substances - chemistry Macromolecular Substances - pharmacology Mice Microbial Sensitivity Tests Molecular Structure Nanotube Particle Size Rats Rats, Sprague-Dawley resveratrol scanning electron microscopy Spectroscopy, Fourier Transform Infrared Surface Properties Sustained release Temperature therapeutics thermogravimetry tissue repair Wound healing Wound Healing - drug effects
Title	Supramolecular hydrogels based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties
URI	https://dx.doi.org/10.1016/j.carbpol.2020.116383 https://www.ncbi.nlm.nih.gov/pubmed/32564841 https://www.proquest.com/docview/2415829165 https://www.proquest.com/docview/2440701071
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