Supramolecular hydrogels based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties

•A cellulose-chalcone hydrogel containing carbon nanotubes was successfully developed.•The hydrogel was characterized by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM.•The hydrogel allows the sustained release of simultaneous therapeutic substances.•Linezolid is more effecti...

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Bibliographic Details
Published in:Carbohydrate polymers Vol. 242; p. 116383
Main Authors: Forero-Doria, Oscar, Polo, Efrain, Marican, Adolfo, Guzmán, Luis, Venegas, Bernardo, Vijayakumar, Sekar, Wehinger, Sergio, Guerrero, Marcelo, Gallego, Jaime, Durán-Lara, Esteban F.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 15.08.2020
Subjects:
allantoin
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
bioactive compounds
carbon nanotubes
Cell Line
Cellulose
Cellulose - chemistry
Cellulose - pharmacology
chalcone
chromatography
crosslinking
Drug Liberation
drugs
Enterococcus faecium - drug effects
Fourier transform infrared spectroscopy
Hydrogel
hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Kinetics
linezolid
Macromolecular Substances - chemistry
Macromolecular Substances - pharmacology
Mice
Microbial Sensitivity Tests
Molecular Structure
Nanotube
Particle Size
Rats
Rats, Sprague-Dawley
resveratrol
scanning electron microscopy
Spectroscopy, Fourier Transform Infrared
Surface Properties
Sustained release
Temperature
therapeutics
thermogravimetry
tissue repair
Wound healing
Wound Healing - drug effects
Sustained release
Antibacterial activity
Wound healing
Hydrogel
Cellulose
Nanotube
ISSN:0144-8617, 1879-1344, 1879-1344
Online Access:Get full text
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Description
Summary:•A cellulose-chalcone hydrogel containing carbon nanotubes was successfully developed.•The hydrogel was characterized by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM.•The hydrogel allows the sustained release of simultaneous therapeutic substances.•Linezolid is more effective when it is sustained-released from the hydrogel. A multifaceted hydrogel-based formulation was reported. The hydrogel was prepared by crosslinking cellulose and substituted chalcone. Moreover, the formulation was conjugated with carbon nanotubes with the aim of increasing the loading amount of bioactive compounds such as allantoin, dexpanthenol, resveratrol and linezolid. The hydrogel formation was confirmed by swelling tests, FT-IR spectroscopy, thermogravimetric analysis and SEM. The hydrogel showed an improved release rate of therapeutic substances, exhibiting a simultaneous and coordinated release according to the chromatographic studies. The efficacy of drug release was confirmed by wound closure and in vivo wound healing studies that showed promising healing results. The antibacterial assays demonstrated that the sustained release of linezolid tends to be very effective. In conclusion, a multifaceted formulation based on carbon nanotube-containing cellulose-chalcone was developed that can potentially be utilized in treating complex wounds owing to its improved wound healing properties and prevention of potential infections.
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ISSN:0144-8617
1879-1344
1879-1344
DOI:10.1016/j.carbpol.2020.116383