Additive varying-coefficient model for nonlinear gene-environment interactions

Gene-environment (G×E) interaction plays a pivotal role in understanding the genetic basis of complex disease. When environmental factors are measured continuously, one can assess the genetic sensitivity over different environmental conditions on a disease trait. Motivated by the increasing awarenes...

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Bibliographic Details
Published in:	Statistical applications in genetics and molecular biology Vol. 17; no. 2
Main Authors:	Wu, Cen, Zhong, Ping-Shou, Cui, Yuehua
Format:	Journal Article
Language:	English
Published:	Germany 2018
Subjects:	Algorithms Birth Weight - genetics Body Mass Index Gene-Environment Interaction Gestational Age Humans Infant, Newborn Models, Genetic Models, Statistical Mothers Phenotype Polymorphism, Single Nucleotide gene-set analysis variable selection B-spline local quadratic approximation SCAD penalty
ISSN:	1544-6115, 1544-6115
Online Access:	Get more information
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