Polypill with or without Aspirin in Persons without Cardiovascular Disease

Participants without cardiovascular disease who were at increased risk were randomly assigned to receive a polypill (containing a statin and three blood-pressure–lowering drugs) or placebo and to receive aspirin or placebo. At 4.6 years, the incidence of cardiovascular events was lower among partici...

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Veröffentlicht in:The New England journal of medicine Jg. 384; H. 3; S. 216 - 228
Hauptverfasser: Yusuf, Salim, Joseph, Philip, Dans, Antonio, Gao, Peggy, Teo, Koon, Xavier, Denis, López-Jaramillo, Patricio, Yusoff, Khalid, Santoso, Anwar, Gamra, Habib, Talukder, Shamim, Christou, Courtney, Girish, Preeti, Yeates, Karen, Xavier, Freeda, Dagenais, Gilles, Rocha, Catalina, McCready, Tara, Tyrwhitt, Jessica, Bosch, Jackie, Pais, Prem
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Massachusetts Medical Society 21.01.2021
Schlagworte:
Aged
Anticholesteremic Agents - administration & dosage
Anticholesteremic Agents - adverse effects
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - adverse effects
Aspirin
Aspirin - therapeutic use
Atenolol
Atenolol - administration & dosage
Blood pressure
Blood Pressure - drug effects
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Cardiovascular Diseases - prevention & control
Cerebral infarction
Cholesterol
Cholesterol, LDL - blood
Confidence intervals
Congestive heart failure
Drug Combinations
Drug dosages
Drug Therapy, Combination
Female
Heart attacks
Humans
Hydrochlorothiazide
Hydrochlorothiazide - administration & dosage
Hypotension
Incidence
Lipids
Male
Medication Adherence
Middle Aged
Myocardial infarction
Pharmaceuticals
Placebos
Platelet Aggregation Inhibitors - therapeutic use
Risk Factors
Simvastatin
Simvastatin - administration & dosage
Statins
Statistical analysis
Stroke
Vitamin D
ISSN:0028-4793, 1533-4406, 1533-4406
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Beschreibung
Zusammenfassung:Participants without cardiovascular disease who were at increased risk were randomly assigned to receive a polypill (containing a statin and three blood-pressure–lowering drugs) or placebo and to receive aspirin or placebo. At 4.6 years, the incidence of cardiovascular events was lower among participants receiving both the polypill and aspirin than among those receiving both placebos.
Bibliographie:ObjectType-Article-1
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ObjectType-Feature-2
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A complete list of investigators in TIPS-3 (the International Polycap Study 3) is provided in the Supplementary Appendix, available at NEJM.org.
ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa2028220