Clinical and molecular characteristics of early-onset vs average-onset esophagogastric cancer
The rate of esophagogastric cancer is rising among individuals under 50 years of age. It remains unknown whether early-onset esophagogastric cancer represents a unique entity. This study investigated the clinical and molecular characteristics of early-onset and average-onset esophagogastric cancer ....
Gespeichert in:
| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute Jg. 116; H. 2; S. 299 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
08.02.2024
|
| Schlagworte: | |
| ISSN: | 1460-2105, 1460-2105 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | The rate of esophagogastric cancer is rising among individuals under 50 years of age. It remains unknown whether early-onset esophagogastric cancer represents a unique entity. This study investigated the clinical and molecular characteristics of early-onset and average-onset esophagogastric cancer .
We reviewed the Memorial Sloan Kettering Cancer Center gastric, esophageal, and gastroesophageal junction cancer database. Associations between baseline characteristics and tumor and germline molecular alterations were compared between those with early-onset and average-onset esophagogastric cancer using Fisher exact tests and the Benjamini-Hochberg method for multiple-hypothesis correction.
We included 1123 patients with early-onset esophagogastric cancer (n = 219; median age = 43 years [range = 18-49 years]) and average-onset esophagogastric cancer (n = 904; median age = 67 years [range = 50-94 years]) treated between 2005 and 2018. The early-onset group had more women (39% vs 28%, P = .002). Patients with early-onset esophagogastric cancer were more likely to have a gastric primary site (64% vs 44%, P < .0001). The signet ring cell and/or diffuse type was 3 times more common in the early-onset esophagogastric cancer group (31% vs 9%, P < .0001). Early-onsite tumors were more frequently genomically stable (31% vs 18%, P = .0002) and unlikely to be microsatellite instability high (2% vs 7%, P = .003). After restricting to adenocarcinoma and signet ring cell and/or diffuse type carcinomas, we observed no difference in stage (P = .40) or overall survival from stage IV diagnosis (median = 22.7 vs 22.1 months, P = .78).
Our study supported a preponderance of gastric primary disease sites, signet ring histology, and genomically stable molecular subtypes in early-onset esophagogastric cancer. Our findings highlight the need for further research to define the underlying pathogenesis and strategies for early detection and prevention. |
|---|---|
| AbstractList | The rate of esophagogastric cancer is rising among individuals under 50 years of age. It remains unknown whether early-onset esophagogastric cancer represents a unique entity. This study investigated the clinical and molecular characteristics of early-onset and average-onset esophagogastric cancer .
We reviewed the Memorial Sloan Kettering Cancer Center gastric, esophageal, and gastroesophageal junction cancer database. Associations between baseline characteristics and tumor and germline molecular alterations were compared between those with early-onset and average-onset esophagogastric cancer using Fisher exact tests and the Benjamini-Hochberg method for multiple-hypothesis correction.
We included 1123 patients with early-onset esophagogastric cancer (n = 219; median age = 43 years [range = 18-49 years]) and average-onset esophagogastric cancer (n = 904; median age = 67 years [range = 50-94 years]) treated between 2005 and 2018. The early-onset group had more women (39% vs 28%, P = .002). Patients with early-onset esophagogastric cancer were more likely to have a gastric primary site (64% vs 44%, P < .0001). The signet ring cell and/or diffuse type was 3 times more common in the early-onset esophagogastric cancer group (31% vs 9%, P < .0001). Early-onsite tumors were more frequently genomically stable (31% vs 18%, P = .0002) and unlikely to be microsatellite instability high (2% vs 7%, P = .003). After restricting to adenocarcinoma and signet ring cell and/or diffuse type carcinomas, we observed no difference in stage (P = .40) or overall survival from stage IV diagnosis (median = 22.7 vs 22.1 months, P = .78).
Our study supported a preponderance of gastric primary disease sites, signet ring histology, and genomically stable molecular subtypes in early-onset esophagogastric cancer. Our findings highlight the need for further research to define the underlying pathogenesis and strategies for early detection and prevention. The rate of esophagogastric cancer is rising among individuals under 50 years of age. It remains unknown whether early-onset esophagogastric cancer represents a unique entity. This study investigated the clinical and molecular characteristics of early-onset and average-onset esophagogastric cancer .BACKGROUNDThe rate of esophagogastric cancer is rising among individuals under 50 years of age. It remains unknown whether early-onset esophagogastric cancer represents a unique entity. This study investigated the clinical and molecular characteristics of early-onset and average-onset esophagogastric cancer .We reviewed the Memorial Sloan Kettering Cancer Center gastric, esophageal, and gastroesophageal junction cancer database. Associations between baseline characteristics and tumor and germline molecular alterations were compared between those with early-onset and average-onset esophagogastric cancer using Fisher exact tests and the Benjamini-Hochberg method for multiple-hypothesis correction.METHODSWe reviewed the Memorial Sloan Kettering Cancer Center gastric, esophageal, and gastroesophageal junction cancer database. Associations between baseline characteristics and tumor and germline molecular alterations were compared between those with early-onset and average-onset esophagogastric cancer using Fisher exact tests and the Benjamini-Hochberg method for multiple-hypothesis correction.We included 1123 patients with early-onset esophagogastric cancer (n = 219; median age = 43 years [range = 18-49 years]) and average-onset esophagogastric cancer (n = 904; median age = 67 years [range = 50-94 years]) treated between 2005 and 2018. The early-onset group had more women (39% vs 28%, P = .002). Patients with early-onset esophagogastric cancer were more likely to have a gastric primary site (64% vs 44%, P < .0001). The signet ring cell and/or diffuse type was 3 times more common in the early-onset esophagogastric cancer group (31% vs 9%, P < .0001). Early-onsite tumors were more frequently genomically stable (31% vs 18%, P = .0002) and unlikely to be microsatellite instability high (2% vs 7%, P = .003). After restricting to adenocarcinoma and signet ring cell and/or diffuse type carcinomas, we observed no difference in stage (P = .40) or overall survival from stage IV diagnosis (median = 22.7 vs 22.1 months, P = .78).RESULTSWe included 1123 patients with early-onset esophagogastric cancer (n = 219; median age = 43 years [range = 18-49 years]) and average-onset esophagogastric cancer (n = 904; median age = 67 years [range = 50-94 years]) treated between 2005 and 2018. The early-onset group had more women (39% vs 28%, P = .002). Patients with early-onset esophagogastric cancer were more likely to have a gastric primary site (64% vs 44%, P < .0001). The signet ring cell and/or diffuse type was 3 times more common in the early-onset esophagogastric cancer group (31% vs 9%, P < .0001). Early-onsite tumors were more frequently genomically stable (31% vs 18%, P = .0002) and unlikely to be microsatellite instability high (2% vs 7%, P = .003). After restricting to adenocarcinoma and signet ring cell and/or diffuse type carcinomas, we observed no difference in stage (P = .40) or overall survival from stage IV diagnosis (median = 22.7 vs 22.1 months, P = .78).Our study supported a preponderance of gastric primary disease sites, signet ring histology, and genomically stable molecular subtypes in early-onset esophagogastric cancer. Our findings highlight the need for further research to define the underlying pathogenesis and strategies for early detection and prevention.CONCLUSIONSOur study supported a preponderance of gastric primary disease sites, signet ring histology, and genomically stable molecular subtypes in early-onset esophagogastric cancer. Our findings highlight the need for further research to define the underlying pathogenesis and strategies for early detection and prevention. |
| Author | Schultz, Nikolaus Joshi, Smita S Cercek, Andrea Tang, Laura H Molena, Daniela Janjigian, Yelena Y Jones, David R Gerdes, Hans Won, Elizabeth Maio, Anna Sihag, Smita Kemel, Yelena Ilson, David H Coit, Daniel G Chatila, Walid Li, Jia Strong, Vivian E Ku, Geoffrey Y Maron, Steven B Walch, Henry Lumish, Melissa A Gu, Ping Schattner, Mark A Laszkowska, Monika Stadler, Zsofia K |
| Author_xml | – sequence: 1 givenname: Melissa A orcidid: 0000-0003-4173-5567 surname: Lumish fullname: Lumish, Melissa A organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA – sequence: 2 givenname: Henry orcidid: 0000-0003-1188-350X surname: Walch fullname: Walch, Henry organization: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 3 givenname: Steven B surname: Maron fullname: Maron, Steven B organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA – sequence: 4 givenname: Walid orcidid: 0000-0001-5474-218X surname: Chatila fullname: Chatila, Walid organization: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 5 givenname: Yelena orcidid: 0000-0002-5042-5651 surname: Kemel fullname: Kemel, Yelena organization: Robert and Kate Niehaus Center for Inherited Cancer Genomics, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 6 givenname: Anna surname: Maio fullname: Maio, Anna organization: Robert and Kate Niehaus Center for Inherited Cancer Genomics, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 7 givenname: Geoffrey Y orcidid: 0000-0002-0448-1038 surname: Ku fullname: Ku, Geoffrey Y organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA – sequence: 8 givenname: David H orcidid: 0000-0003-0831-2247 surname: Ilson fullname: Ilson, David H organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA – sequence: 9 givenname: Elizabeth orcidid: 0000-0001-5901-750X surname: Won fullname: Won, Elizabeth organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA – sequence: 10 givenname: Jia surname: Li fullname: Li, Jia organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA – sequence: 11 givenname: Smita S surname: Joshi fullname: Joshi, Smita S organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA – sequence: 12 givenname: Ping surname: Gu fullname: Gu, Ping organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA – sequence: 13 givenname: Mark A surname: Schattner fullname: Schattner, Mark A organization: Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 14 givenname: Monika orcidid: 0000-0001-6816-3293 surname: Laszkowska fullname: Laszkowska, Monika organization: Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 15 givenname: Hans surname: Gerdes fullname: Gerdes, Hans organization: Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 16 givenname: David R surname: Jones fullname: Jones, David R organization: Department of Surgery Memorial, Sloan Kettering Cancer Center, New York, NY, USA – sequence: 17 givenname: Smita surname: Sihag fullname: Sihag, Smita organization: Department of Surgery Memorial, Sloan Kettering Cancer Center, New York, NY, USA – sequence: 18 givenname: Daniel G orcidid: 0000-0001-8901-1555 surname: Coit fullname: Coit, Daniel G organization: Department of Surgery Memorial, Sloan Kettering Cancer Center, New York, NY, USA – sequence: 19 givenname: Laura H surname: Tang fullname: Tang, Laura H organization: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 20 givenname: Vivian E surname: Strong fullname: Strong, Vivian E organization: Department of Surgery Memorial, Sloan Kettering Cancer Center, New York, NY, USA – sequence: 21 givenname: Daniela surname: Molena fullname: Molena, Daniela organization: Department of Surgery Memorial, Sloan Kettering Cancer Center, New York, NY, USA – sequence: 22 givenname: Zsofia K surname: Stadler fullname: Stadler, Zsofia K organization: Robert and Kate Niehaus Center for Inherited Cancer Genomics, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 23 givenname: Nikolaus surname: Schultz fullname: Schultz, Nikolaus organization: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 24 givenname: Yelena Y surname: Janjigian fullname: Janjigian, Yelena Y organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA – sequence: 25 givenname: Andrea orcidid: 0000-0002-5054-8192 surname: Cercek fullname: Cercek, Andrea organization: Department of Medicine, Weill Cornell Medical College, New York, NY, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37699004$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkD1rwzAYhEVJaT7arXPR2MWNJMuSPZbQLwh0acdiXsuvEwVZSiU7kH_fQFPoLXccDzfcnEx88EjILWcPnFX5cueNXbY7aHmpLsiMS8UywVkx-ZenZJ7Sjp1UCXlFprlWVcWYnJGvlbPeGnAUfEv74NCMDiI1W4hgBow2DdYkGjqKEN0xCz7hQA-JwgEjbPBcYAr7LWzCBtIQraEGvMF4TS47cAlvzr4gn89PH6vXbP3-8rZ6XGdGymLIoCkYyLLLu6ZqlNSNFtxIbYxWuTDYcCUw71psBeoux6IwbaWY0E2nFZSiEgty_7u7j-F7xDTUvU0GnQOPYUy1KJVUvCyr8oTendGx6bGt99H2EI_13yXiB7X6Z0k |
| CitedBy_id | crossref_primary_10_1111_jgh_17012 crossref_primary_10_1016_j_intimp_2024_113436 crossref_primary_10_1371_journal_pone_0315391 crossref_primary_10_3390_curroncol32090480 crossref_primary_10_3748_wjg_v30_i38_4221 crossref_primary_10_4251_wjgo_v16_i3_583 crossref_primary_10_1016_S0140_6736_25_00052_2 crossref_primary_10_1186_s12885_025_13767_z crossref_primary_10_1007_s10120_023_01443_9 crossref_primary_10_1038_s41698_025_01030_4 crossref_primary_10_1080_08998280_2025_2488592 crossref_primary_10_1002_cam4_70451 crossref_primary_10_1007_s10120_025_01584_z crossref_primary_10_1177_26345161251354937 crossref_primary_10_1186_s12957_025_03867_2 crossref_primary_10_1038_s41598_025_08618_7 crossref_primary_10_1097_MD_0000000000038098 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
| Copyright_xml | – notice: The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1093/jnci/djad186 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1460-2105 |
| ExternalDocumentID | 37699004 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: P30 CA008748 – fundername: NIH HHS |
| GroupedDBID | --- -E4 -~X .2P .I3 .XZ .ZR 08P 0R~ 1TH 29L 2WC 354 4.4 482 48X 5GY 5RE 5VS 5WD 70D 96U AABZA AACZT AAHTB AAJKP AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AAUAY AAVAP AAWTL ABCQX ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABNHQ ABNKS ABOCM ABPEJ ABPPZ ABPTD ABQLI ABQNK ABVGC ABXVV ABZBJ ACBMB ACGFO ACGFS ACGOD ACKOT ACNCT ACPRK ACUFI ACUTO ACYHN ADBBV ADEYI ADEZT ADGZP ADHKW ADHZD ADIPN ADNBA ADOCK ADQBN ADRTK ADVEK ADYVW AEGPL AEJOX AEKSI AEMDU AEMQT AENZO AEPUE AETBJ AEWNT AFAZI AFFNX AFFZL AFIYH AFOFC AFRAH AFXAL AFYAG AGINJ AGKEF AGORE AGSYK AGUTN AHGBF AHMBA AHMMS AHXPO AIAGR AIJHB AJBYB AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APWMN ATGXG BAWUL BAYMD BCRHZ BEYMZ BTRTY BVRKM C45 CDBKE CGR CS3 CUY CVF CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS ECM EE~ EIF EMOBN ENERS F5P F8P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HW0 HZ~ IH2 IOX J21 JXSIZ KAQDR KOP KQ8 KSI KSN L7B M-Z MHKGH ML0 N9A NGC NOMLY NOYVH NPM NU- OAUYM OAWHX OBH OCB OCZFY ODMLO ODZKP OGEVE OHH OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P PAFKI PEELM PQQKQ Q.- Q1. Q5Y R44 RD5 RNS ROL ROX ROZ RUSNO RW1 RXO TCURE TEORI TJX TMA TR2 TWZ UDS UPT VVN W8F WH7 WOQ X7H YAYTL YKOAZ YQT YXANX ZKX ZRR ZY1 ~91 ~H1 7X8 |
| ID | FETCH-LOGICAL-c445t-ab50a48f3fb9b647b721c47cc7632ceb162e3fded2e7f3e55cd96027bf76a8292 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 23 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001103540500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1460-2105 |
| IngestDate | Thu Oct 02 12:04:21 EDT 2025 Tue Jun 17 01:30:27 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c445t-ab50a48f3fb9b647b721c47cc7632ceb162e3fded2e7f3e55cd96027bf76a8292 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ORCID | 0000-0002-5042-5651 0000-0003-4173-5567 0000-0002-0448-1038 0000-0002-5054-8192 0000-0003-1188-350X 0000-0001-6816-3293 0000-0003-0831-2247 0000-0001-8901-1555 0000-0001-5901-750X 0000-0001-5474-218X |
| OpenAccessLink | https://pmc.ncbi.nlm.nih.gov/articles/PMC10852615/pdf/djad186.pdf |
| PMID | 37699004 |
| PQID | 2864618898 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2864618898 pubmed_primary_37699004 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-02-08 |
| PublicationDateYYYYMMDD | 2024-02-08 |
| PublicationDate_xml | – month: 02 year: 2024 text: 2024-02-08 day: 08 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | JNCI : Journal of the National Cancer Institute |
| PublicationTitleAlternate | J Natl Cancer Inst |
| PublicationYear | 2024 |
| SSID | ssj0000924 |
| Score | 2.556843 |
| SecondaryResourceType | review_article |
| Snippet | The rate of esophagogastric cancer is rising among individuals under 50 years of age. It remains unknown whether early-onset esophagogastric cancer represents... The rate of esophagogastric cancer is rising among individuals under 50 years of age. It remains unknown whether early-onset esophagogastric cancer represents... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 299 |
| SubjectTerms | Adenocarcinoma - epidemiology Adenocarcinoma - genetics Adolescent Adult Aged Aged, 80 and over Carcinoma, Signet Ring Cell - metabolism Carcinoma, Signet Ring Cell - pathology Cardia - metabolism Esophageal Neoplasms - epidemiology Esophageal Neoplasms - genetics Esophagogastric Junction - metabolism Esophagogastric Junction - pathology Female Humans Middle Aged Retrospective Studies Stomach Neoplasms - diagnosis Stomach Neoplasms - epidemiology Stomach Neoplasms - genetics Young Adult |
| Title | Clinical and molecular characteristics of early-onset vs average-onset esophagogastric cancer |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37699004 https://www.proquest.com/docview/2864618898 |
| Volume | 116 |
| WOSCitedRecordID | wos001103540500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7Uinjx_agvVvC6NNlsNpuTiFg82NKDQi9S9lkqmtSm9vc7m2wpHgTByx4CCWGY_XZm5-P7ELqJs9hJRQ2JrI0IU04QKVQEizO-bZapqtX1n7J-XwyH-SBcuFWBVrnExBqoTan9HXmHCs54LEQubqefxLtG-elqsNBYR60EShlP6cqGK7XwKG9MbRmPCLQ2aSC-QxPfeSv0pGPepIkF_724rA-Z7u5_f28P7YTyEt81-bCP1mxxgLZ6YYB-iF6DDug7loXBH0tvXKx_6jbj0mHrpY-JJ1vP8aLCEnIesCc8sN79QI7LsfS-HxprnzyzI_TSfXi-fyTBYYFoxtI5kSqNJBMucSpXnGUK-kHNMq0BdagGGOfUJs5YQ23mEpum2kDHQzPlMi4Fzekx2ijKwp4izHRCI2UTrmQOJRhV8FlHXa4tN7EztI2ul4EbQQb7sYQsbPlVjVaha6OTJvqjaSO1MQL4g-MyYmd_ePscbVOoOGpKtbhALQf7116iTb2YT6rZVZ0asPYHvW8-3ceF |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clinical+and+molecular+characteristics+of+early-onset+vs+average-onset+esophagogastric+cancer&rft.jtitle=JNCI+%3A+Journal+of+the+National+Cancer+Institute&rft.au=Lumish%2C+Melissa+A&rft.au=Walch%2C+Henry&rft.au=Maron%2C+Steven+B&rft.au=Chatila%2C+Walid&rft.date=2024-02-08&rft.issn=1460-2105&rft.eissn=1460-2105&rft.volume=116&rft.issue=2&rft.spage=299&rft_id=info:doi/10.1093%2Fjnci%2Fdjad186&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1460-2105&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1460-2105&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1460-2105&client=summon |