Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor

Aim： Glyoxalase I （GLOI）, a glutathione （GSH）-dependent enzyme, is overexpressed in tumor cells and related to multi-drug resistance in chemotherapy, making GLOI inhibitors as potential anti-tumor agents. But the most studied GSH analogs exhibit poor pharmacokinetic properties. The aim of this study...

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Bibliographic Details
Published in:	Acta pharmacologica Sinica Vol. 36; no. 9; pp. 1145 - 1150
Main Authors:	Zhang, Hong, Huang, Qiang, Zhai, Jing, Zhao, Yi-ning, Zhang, Li-ping, Chen, Yun-yun, Zhang, Ren-wei, Li, Qing, Hu, Xiao-peng
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.09.2015 Nature Publishing Group
Subjects:	Animals Biomedical and Life Sciences Biomedicine Crystallography, X-Ray Drug Discovery Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - chemistry Glycyrrhetinic Acid - pharmacology GSH Immunology Internal Medicine Lactoylglutathione Lyase - antagonists & inhibitors Lactoylglutathione Lyase - chemistry Lactoylglutathione Lyase - metabolism Medical Microbiology Mice Molecular Docking Simulation Original original-article Pharmacology/Toxicology Vaccine 三萜类化合物天然化合物抑制剂模拟甘草次酸结构基础谷胱甘肽 carbenoxolone pentacyclic triterpenes GSH binding site 18-β-glycyrrhetinic acid molecular docking crystal structure glyoxalase I
ISSN:	1671-4083, 1745-7254, 1745-7254
Online Access:	Get full text
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