Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor

Aim： Glyoxalase I （GLOI）, a glutathione （GSH）-dependent enzyme, is overexpressed in tumor cells and related to multi-drug resistance in chemotherapy, making GLOI inhibitors as potential anti-tumor agents. But the most studied GSH analogs exhibit poor pharmacokinetic properties. The aim of this study...

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Vydáno v:	Acta pharmacologica Sinica Ročník 36; číslo 9; s. 1145 - 1150
Hlavní autoři:	Zhang, Hong, Huang, Qiang, Zhai, Jing, Zhao, Yi-ning, Zhang, Li-ping, Chen, Yun-yun, Zhang, Ren-wei, Li, Qing, Hu, Xiao-peng
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.09.2015 Nature Publishing Group
Témata:	Animals Biomedical and Life Sciences Biomedicine Crystallography, X-Ray Drug Discovery Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - chemistry Glycyrrhetinic Acid - pharmacology GSH Immunology Internal Medicine Lactoylglutathione Lyase - antagonists & inhibitors Lactoylglutathione Lyase - chemistry Lactoylglutathione Lyase - metabolism Medical Microbiology Mice Molecular Docking Simulation Original original-article Pharmacology/Toxicology Vaccine 三萜类化合物天然化合物抑制剂模拟甘草次酸结构基础谷胱甘肽 carbenoxolone pentacyclic triterpenes GSH binding site 18-β-glycyrrhetinic acid molecular docking crystal structure glyoxalase I
ISSN:	1671-4083, 1745-7254, 1745-7254
On-line přístup:	Získat plný text
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