Tribulus terrestris ameliorates carbon tetrachloride-induced hepatotoxicity in male rats through suppression of oxidative stress and inflammation

Hepatoprotection is a goal for the harmful effect of several hepatotoxic agents. The present study has been executed to assess the useful impacts of Tribulus terrestris (TT) and silymarin (SLM) against carbon tetrachloride (CCL 4 )-induced hepatotoxicity. Forty-two male rats were partitioned into si...

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Published in:Environmental science and pollution research international Vol. 27; no. 20; pp. 24967 - 24981
Main Authors: Kilany, Omnia E., El-Beltagy, Marwa A., El-Sherbeeny, Nagla A.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2020
Springer Nature B.V
Subjects:
Antioxidants
Apoptosis
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Bcl-2 protein
Biomarkers
blood serum
Carbon
Carbon tetrachloride
CCL4 protein
Corn oil
Cytokines
Distilled water
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
hepatoprotective effect
Hepatotoxicity
histopathology
immunohistochemistry
Inflammation
Injection
Intoxication
Lipid peroxidation
Lipids
Liver
males
Oils & fats
Oxidative stress
Peroxidation
poisoning
pollution
Pretreatment
Research Article
Rodents
Silymarin
Tribulus terrestris
Waste Water Technology
Water Management
Water Pollution Control
Silymarin
Oxidative damage
Liver
Interleukin
Inflammation
Antioxidant
Hepatotoxicity
Tribulus terrestris
ISSN:0944-1344, 1614-7499, 1614-7499
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Summary:Hepatoprotection is a goal for the harmful effect of several hepatotoxic agents. The present study has been executed to assess the useful impacts of Tribulus terrestris (TT) and silymarin (SLM) against carbon tetrachloride (CCL 4 )-induced hepatotoxicity. Forty-two male rats were partitioned into six groups: group I: received 0.3% CMC-Na in distilled water, group II: TT (500 mg/kg BW, orally), group III: SLM (200 mg/kg, orally) for 14 consecutive days (on days 11 and 12 intraperitoneal corn oil), group IV: CCL 4 , group V: TT (500 mg/kg BW) plus CCL 4 , and group VI: SLM (200 mg/kg orally) plus CCL 4 . The CCL 4 was administered (2.0 ml/kg BW) intraperitoneal on days 11 and 12. Sera were collected for assessment of hepatic injury markers and pro-inflammatory cytokines. Additionally, liver tissue oxidative stress, lipid peroxidation, histopathological examination, and immunohistochemical analysis (Bax and bcl-2) were done. CCL 4 injection induced significant reductions in hepatic antioxidants while increased hepatic lipid peroxidation as well as serum hepatic injury biomarkers and pro-inflammatory cytokines. The histopathological examination showed necrotic and degenerative changes in the hepatic tissue, while immunohistochemical analysis revealed marked hepatic expression of activated Bax, and bcl-2, following CCL 4 injection. TT pretreatment significantly improved all examined parameters and restored the hepatic architecture. The current study illustrated that TT effectively alleviates hepatic oxidative damage, apoptosis, and inflammation, induced by acute CCL 4 intoxication. In this manner, TT has promising cytoprotective powers against hepatotoxicity induced by CCL 4 .
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ISSN:0944-1344
1614-7499
1614-7499
DOI:10.1007/s11356-020-08826-w