Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques
The development of atherosclerotic plaques is a critical step that can result in an arterial embolism. Therefore, detection of these vulnerable plaques is of clinical significance for the diagnosis of atherosclerosis. However, there are few imaging systems able to detect such plaques easily. In this...
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| Vydáno v: | Journal of controlled release Ročník 302; s. 105 - 115 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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28.05.2019
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| ISSN: | 0168-3659, 1873-4995, 1873-4995 |
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| Abstract | The development of atherosclerotic plaques is a critical step that can result in an arterial embolism. Therefore, detection of these vulnerable plaques is of clinical significance for the diagnosis of atherosclerosis. However, there are few imaging systems able to detect such plaques easily. In this study, we designed a new platform for near-infrared fluorescence (NIRF) imaging of macrophages in atherosclerotic plaques, one using both a liposomal DDS and an activatable fluorescent probe, and evaluated the utility of this imaging for the diagnosis of atherosclerosis. We first synthesized a fluorescent switch-on probe, Peptide-ICG2, which is optically silent under normal conditions but activated in the presence of the lysosomal enzyme, cathepsin B. To achieve macrophage-specific fluorescence activation, we encapsulated Peptide-ICG2 into phosphatidylserine-containing liposome (P-ICG2-PS-Lip), since the accumulation of phosphatidylserine receptor-bearing macrophages is characteristic of embolism-vulnerable plaques. The experiments using macrophage-like RAW264 cells in culture showed that P-ICG2-PS-Lip was selectively taken up into the cells and that significant fluorescence of the probe was observed. For NIRF imaging of the atherosclerotic plaques, P-ICG2-PS-Lip was intravenously injected into ApoE-knockout atherosclerotic model mice or WHHL rabbits, and the fluorescence at the aortae was imaged. The results indicated that ICG fluorescence could be successfully observed at the plaques on the artery walls. The results of the present study thus suggest that NIRF imaging using P-ICG2-PS-Lip would be useful for detecting embolism-vulnerable atherosclerotic plaques. |
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| AbstractList | The development of atherosclerotic plaques is a critical step that can result in an arterial embolism. Therefore, detection of these vulnerable plaques is of clinical significance for the diagnosis of atherosclerosis. However, there are few imaging systems able to detect such plaques easily. In this study, we designed a new platform for near-infrared fluorescence (NIRF) imaging of macrophages in atherosclerotic plaques, one using both a liposomal DDS and an activatable fluorescent probe, and evaluated the utility of this imaging for the diagnosis of atherosclerosis. We first synthesized a fluorescent switch-on probe, Peptide-ICG2, which is optically silent under normal conditions but activated in the presence of the lysosomal enzyme, cathepsin B. To achieve macrophage-specific fluorescence activation, we encapsulated Peptide-ICG2 into phosphatidylserine-containing liposome (P-ICG2-PS-Lip), since the accumulation of phosphatidylserine receptor-bearing macrophages is characteristic of embolism-vulnerable plaques. The experiments using macrophage-like RAW264 cells in culture showed that P-ICG2-PS-Lip was selectively taken up into the cells and that significant fluorescence of the probe was observed. For NIRF imaging of the atherosclerotic plaques, P-ICG2-PS-Lip was intravenously injected into ApoE-knockout atherosclerotic model mice or WHHL rabbits, and the fluorescence at the aortae was imaged. The results indicated that ICG fluorescence could be successfully observed at the plaques on the artery walls. The results of the present study thus suggest that NIRF imaging using P-ICG2-PS-Lip would be useful for detecting embolism-vulnerable atherosclerotic plaques. The development of atherosclerotic plaques is a critical step that can result in an arterial embolism. Therefore, detection of these vulnerable plaques is of clinical significance for the diagnosis of atherosclerosis. However, there are few imaging systems able to detect such plaques easily. In this study, we designed a new platform for near-infrared fluorescence (NIRF) imaging of macrophages in atherosclerotic plaques, one using both a liposomal DDS and an activatable fluorescent probe, and evaluated the utility of this imaging for the diagnosis of atherosclerosis. We first synthesized a fluorescent switch-on probe, Peptide-ICG2, which is optically silent under normal conditions but activated in the presence of the lysosomal enzyme, cathepsin B. To achieve macrophage-specific fluorescence activation, we encapsulated Peptide-ICG2 into phosphatidylserine-containing liposome (P-ICG2-PS-Lip), since the accumulation of phosphatidylserine receptor-bearing macrophages is characteristic of embolism-vulnerable plaques. The experiments using macrophage-like RAW264 cells in culture showed that P-ICG2-PS-Lip was selectively taken up into the cells and that significant fluorescence of the probe was observed. For NIRF imaging of the atherosclerotic plaques, P-ICG2-PS-Lip was intravenously injected into ApoE-knockout atherosclerotic model mice or WHHL rabbits, and the fluorescence at the aortae was imaged. The results indicated that ICG fluorescence could be successfully observed at the plaques on the artery walls. The results of the present study thus suggest that NIRF imaging using P-ICG2-PS-Lip would be useful for detecting embolism-vulnerable atherosclerotic plaques.The development of atherosclerotic plaques is a critical step that can result in an arterial embolism. Therefore, detection of these vulnerable plaques is of clinical significance for the diagnosis of atherosclerosis. However, there are few imaging systems able to detect such plaques easily. In this study, we designed a new platform for near-infrared fluorescence (NIRF) imaging of macrophages in atherosclerotic plaques, one using both a liposomal DDS and an activatable fluorescent probe, and evaluated the utility of this imaging for the diagnosis of atherosclerosis. We first synthesized a fluorescent switch-on probe, Peptide-ICG2, which is optically silent under normal conditions but activated in the presence of the lysosomal enzyme, cathepsin B. To achieve macrophage-specific fluorescence activation, we encapsulated Peptide-ICG2 into phosphatidylserine-containing liposome (P-ICG2-PS-Lip), since the accumulation of phosphatidylserine receptor-bearing macrophages is characteristic of embolism-vulnerable plaques. The experiments using macrophage-like RAW264 cells in culture showed that P-ICG2-PS-Lip was selectively taken up into the cells and that significant fluorescence of the probe was observed. For NIRF imaging of the atherosclerotic plaques, P-ICG2-PS-Lip was intravenously injected into ApoE-knockout atherosclerotic model mice or WHHL rabbits, and the fluorescence at the aortae was imaged. The results indicated that ICG fluorescence could be successfully observed at the plaques on the artery walls. The results of the present study thus suggest that NIRF imaging using P-ICG2-PS-Lip would be useful for detecting embolism-vulnerable atherosclerotic plaques. |
| Author | Maess, Marten B. Narita, Yudai Shimizu, Kosuke Kosugi, Mutsumi Uchino, Ryuji Ogawa, Mikako Magata, Yasuhiro Ikemoto, Keisuke Oku, Naoto |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30936020$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1021/cb900089j 10.1038/nature06307 10.1097/00041433-199610000-00012 10.1093/jmcb/mjp045 10.1016/j.biomaterials.2018.02.041 10.1136/heartjnl-2017-311447 10.1016/0014-5793(95)00287-J 10.1111/j.1540-8183.2002.tb01087.x 10.1007/s12410-014-9293-x 10.1021/bc010063m 10.1038/nm.1854 10.1161/STROKEAHA.115.011573 10.3390/ijms17071187 10.1038/35025203 10.1039/c004573j 10.1096/fj.01-0463com 10.1126/scitranslmed.3005101 10.1073/pnas.95.8.4516 10.2310/7290.2009.00027 10.1038/labinvest.2016.94 10.1016/j.jacc.2013.11.034 10.1016/j.jcmg.2015.06.013 10.1016/j.jacc.2011.02.036 10.1161/CIRCINTERVENTIONS.114.001498 10.1186/s13550-017-0287-y 10.3390/ma11050754 10.1074/jbc.M510952200 10.1021/ja010983f 10.1016/j.jconrel.2018.06.029 10.1038/nrd3578 10.1016/S0002-9149(00)01339-4 10.1126/science.1411543 10.1016/j.jacc.2011.12.037 10.2967/jnumed.111.092866 10.1093/emboj/20.17.4629 10.1016/0735-1097(94)90772-2 10.1101/cshperspect.a009076 10.1038/417182a 10.1016/j.jcmg.2013.08.006 10.1161/CIRCRESAHA.114.302721 10.1016/j.jconrel.2017.02.018 10.1371/journal.pone.0160522 10.1016/j.tcb.2015.08.003 10.1016/0005-2736(95)00214-6 10.1016/j.immuni.2011.09.004 10.1016/S0140-6736(13)61754-7 10.1021/cr900263j 10.1016/S0002-9440(10)64254-X 10.1161/ATVBAHA.109.193086 10.2133/dmpk.21.37 10.3181/00379727-122-31299 10.2967/jnumed.113.123158 10.1016/j.jacc.2009.12.061 10.1189/jlb.1005550 10.1080/03639040701833559 10.3892/ijo.2012.1754 10.1016/j.tips.2010.01.003 10.1016/0005-2736(92)90086-2 10.1016/j.bbrc.2004.03.037 10.1111/febs.14043 |
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| Keywords | Cathepsin B Liposome Fluorescence imaging Atherosclerotic vulnerable plaque Phosphatidylserine Macrophage |
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| References | Rudd (10.1016/j.jconrel.2019.03.025_bb0065) 2010; 55 Ogawa (10.1016/j.jconrel.2019.03.025_bb0195) 2009; 4 Joshi (10.1016/j.jconrel.2019.03.025_bb0080) 2014; 383 Ogawa (10.1016/j.jconrel.2019.03.025_bb0095) 2006; 47 Kim (10.1016/j.jconrel.2019.03.025_bb0135) 2009; 8 Clerc (10.1016/j.jconrel.2019.03.025_bb0250) 1995; 1240 Sheng (10.1016/j.jconrel.2019.03.025_bb0245) 2018; 165 Ogawa (10.1016/j.jconrel.2019.03.025_bb0090) 2012; 53 Gardai (10.1016/j.jconrel.2019.03.025_bb0215) 2006; 79 Qin (10.1016/j.jconrel.2019.03.025_bb0255) 2008; 34 Varasteh (10.1016/j.jconrel.2019.03.025_bb0040) 2017; 7 Chono (10.1016/j.jconrel.2019.03.025_bb0230) 2006; 21 Lemke (10.1016/j.jconrel.2019.03.025_bb0205) 2013; 5 Segawa (10.1016/j.jconrel.2019.03.025_bb0165) 2015; 25 Dweck (10.1016/j.jconrel.2019.03.025_bb0075) 2012; 59 Shi (10.1016/j.jconrel.2019.03.025_bb0300) 2004; 317 Ogawa (10.1016/j.jconrel.2019.03.025_bb0085) 2004; 45 Setiawan (10.1016/j.jconrel.2019.03.025_bb0190) 2010; 12 Nahrendorf (10.1016/j.jconrel.2019.03.025_bb0140) 2009; 29 Libby (10.1016/j.jconrel.2019.03.025_bb0030) 1996; 7 Moghadasian (10.1016/j.jconrel.2019.03.025_bb0295) 2001; 15 Weiss-Sadan (10.1016/j.jconrel.2019.03.025_bb0130) 2017; 284 MacRitchie (10.1016/j.jconrel.2019.03.025_bb0045) 2018; 104 Ravichandran (10.1016/j.jconrel.2019.03.025_bb0225) 2011; 35 Virmani (10.1016/j.jconrel.2019.03.025_bb0015) 2002; 15 Ogawa (10.1016/j.jconrel.2019.03.025_bb0100) 2014; 55 Zhong (10.1016/j.jconrel.2019.03.025_bb0180) 2013; 42 Turk (10.1016/j.jconrel.2019.03.025_bb0270) 2001; 20 Libby (10.1016/j.jconrel.2019.03.025_bb0035) 2000; 86 Godin (10.1016/j.jconrel.2019.03.025_bb0305) 2010; 31 Ehara (10.1016/j.jconrel.2019.03.025_bb0060) 2016; 17 Lusis (10.1016/j.jconrel.2019.03.025_bb0005) 2000; 407 Xu (10.1016/j.jconrel.2019.03.025_bb0285) 2016; 96 Mauldin (10.1016/j.jconrel.2019.03.025_bb0170) 2006; 281 Urano (10.1016/j.jconrel.2019.03.025_bb0105) 2009; 15 Press (10.1016/j.jconrel.2019.03.025_bb0150) 2014; 7 Zhang (10.1016/j.jconrel.2019.03.025_bb0290) 1992; 258 Lah (10.1016/j.jconrel.2019.03.025_bb0280) 1995; 363 Figueroa (10.1016/j.jconrel.2019.03.025_bb0070) 2013; 6 Abd-Elrahman (10.1016/j.jconrel.2019.03.025_bb0120) 2016; 47 Matsumoto (10.1016/j.jconrel.2019.03.025_bb0055) 2015; 8 Lee (10.1016/j.jconrel.2019.03.025_bb0265) 1992; 1103 Miyanishi (10.1016/j.jconrel.2019.03.025_bb0210) 2007; 450 Jormsjö (10.1016/j.jconrel.2019.03.025_bb0115) 2002; 161 Kobayashi (10.1016/j.jconrel.2019.03.025_bb0110) 2010; 110 Andriyanov (10.1016/j.jconrel.2019.03.025_bb0235) 2017; 257 Bentzon (10.1016/j.jconrel.2019.03.025_bb0020) 2014; 114 Jaffer (10.1016/j.jconrel.2019.03.025_bb0160) 2011; 57 Peter (10.1016/j.jconrel.2019.03.025_bb0220) 2010; 2 Abd-Elrahman (10.1016/j.jconrel.2019.03.025_bb0145) 2016; 11 Lajunen (10.1016/j.jconrel.2019.03.025_bb0240) 2018; 284 Muller (10.1016/j.jconrel.2019.03.025_bb0025) 1994; 23 Hanayama (10.1016/j.jconrel.2019.03.025_bb0200) 2002; 417 Bergström (10.1016/j.jconrel.2019.03.025_bb0185) 2002; 124 Lobatto (10.1016/j.jconrel.2019.03.025_bb0310) 2011; 10 DiStasio (10.1016/j.jconrel.2019.03.025_bb0320) 2018; 11 Lee (10.1016/j.jconrel.2019.03.025_bb0155) 2014; 7 Baker (10.1016/j.jconrel.2019.03.025_bb0260) 1966; 122 Mulder (10.1016/j.jconrel.2019.03.025_bb0315) 2014; 6 Kovár (10.1016/j.jconrel.2019.03.025_bb0175) 2002; 13 Noguchi (10.1016/j.jconrel.2019.03.025_bb0050) 2014; 63 Zhao (10.1016/j.jconrel.2019.03.025_bb0125) 2016; 6 Deussing (10.1016/j.jconrel.2019.03.025_bb0275) 1998; 95 |
| References_xml | – volume: 4 start-page: 535 year: 2009 ident: 10.1016/j.jconrel.2019.03.025_bb0195 article-title: H-type dimer formation of fluorophores: a mechanism for activatable, in vivo optical molecular imaging publication-title: ACS Chem. Biol. doi: 10.1021/cb900089j – volume: 450 start-page: 435 year: 2007 ident: 10.1016/j.jconrel.2019.03.025_bb0210 article-title: Identification of Tim4 as a phosphatidylserine receptor publication-title: Nature doi: 10.1038/nature06307 – volume: 7 start-page: 330 year: 1996 ident: 10.1016/j.jconrel.2019.03.025_bb0030 article-title: Macrophages and atherosclerotic plaque stability publication-title: Curr. Opin. Lipidol. doi: 10.1097/00041433-199610000-00012 – volume: 2 start-page: 78 year: 2010 ident: 10.1016/j.jconrel.2019.03.025_bb0220 article-title: Molecular suicide notes: last call from apoptosing cells publication-title: J. Mol. Cell Biol. doi: 10.1093/jmcb/mjp045 – volume: 165 start-page: 1 year: 2018 ident: 10.1016/j.jconrel.2019.03.025_bb0245 article-title: Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2018.02.041 – volume: 104 start-page: 460 year: 2018 ident: 10.1016/j.jconrel.2019.03.025_bb0045 article-title: Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering publication-title: Heart doi: 10.1136/heartjnl-2017-311447 – volume: 363 start-page: 85 year: 1995 ident: 10.1016/j.jconrel.2019.03.025_bb0280 article-title: Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages publication-title: FEBS Lett. doi: 10.1016/0014-5793(95)00287-J – volume: 15 start-page: 439 year: 2002 ident: 10.1016/j.jconrel.2019.03.025_bb0015 article-title: Vulnerable plaque: the pathology of unstable coronary lesions publication-title: J. Interv. Cardiol. doi: 10.1111/j.1540-8183.2002.tb01087.x – volume: 7 start-page: 9293 year: 2014 ident: 10.1016/j.jconrel.2019.03.025_bb0150 article-title: Molecular intravascular imaging approaches for atherosclerosis publication-title: Curr. Cardiovasc. Imaging Rep. doi: 10.1007/s12410-014-9293-x – volume: 13 start-page: 206 year: 2002 ident: 10.1016/j.jconrel.2019.03.025_bb0175 article-title: Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect publication-title: Bioconjug. Chem. doi: 10.1021/bc010063m – volume: 15 start-page: 104 year: 2009 ident: 10.1016/j.jconrel.2019.03.025_bb0105 article-title: Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes publication-title: Nat. Med. doi: 10.1038/nm.1854 – volume: 47 start-page: 1101 year: 2016 ident: 10.1016/j.jconrel.2019.03.025_bb0120 article-title: Characterizing cathepsin activity and macrophage subtypes in excised human carotid plaques publication-title: Stroke doi: 10.1161/STROKEAHA.115.011573 – volume: 17 start-page: E1187 year: 2016 ident: 10.1016/j.jconrel.2019.03.025_bb0060 article-title: The clinical value of high-intensity signals on the coronary atherosclerotic plaques: noncontrast T1-weighted magnetic resonanceimaging publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms17071187 – volume: 47 start-page: 1845 year: 2006 ident: 10.1016/j.jconrel.2019.03.025_bb0095 article-title: Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques publication-title: J. Nucl. Med. – volume: 407 start-page: 233 year: 2000 ident: 10.1016/j.jconrel.2019.03.025_bb0005 article-title: Atherosclerosis publication-title: Nature doi: 10.1038/35025203 – volume: 12 start-page: 11238 year: 2010 ident: 10.1016/j.jconrel.2019.03.025_bb0190 article-title: A first principles study of fluorescence quenching in rhodamine B dimers: how can quenching occur in dimeric species? publication-title: Phys. Chem. Chem. Phys. doi: 10.1039/c004573j – volume: 15 start-page: 2623 year: 2001 ident: 10.1016/j.jconrel.2019.03.025_bb0295 article-title: Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans publication-title: FASEB J. doi: 10.1096/fj.01-0463com – volume: 6 start-page: 239sr1 year: 2014 ident: 10.1016/j.jconrel.2019.03.025_bb0315 article-title: Imaging and nanomedicine in nflammatory atherosclerosis publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3005101 – volume: 95 start-page: 4516 year: 1998 ident: 10.1016/j.jconrel.2019.03.025_bb0275 article-title: Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.95.8.4516 – volume: 8 start-page: 291 year: 2009 ident: 10.1016/j.jconrel.2019.03.025_bb0135 article-title: Molecular imaging of cathepsin B proteolytic enzyme activity reflects the inflammatory component of atherosclerotic pathology and can quantitatively demonstrate the antiatherosclerotic therapeutic effects of atorvastatin and glucosamine publication-title: Mol. Imaging doi: 10.2310/7290.2009.00027 – volume: 96 start-page: 1189 year: 2016 ident: 10.1016/j.jconrel.2019.03.025_bb0285 article-title: Tim-4 protects mice against lipopolysaccharide-induced endotoxic shock by suppressing the NF-κB signaling pathway publication-title: Lab. Investig. doi: 10.1038/labinvest.2016.94 – volume: 63 start-page: 989 year: 2014 ident: 10.1016/j.jconrel.2019.03.025_bb0050 article-title: High-intensity signals in coronary plaques on noncontrast T1-weighted magnetic resonance imaging as a novel determinant of coronary events publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2013.11.034 – volume: 8 start-page: 1143 year: 2015 ident: 10.1016/j.jconrel.2019.03.025_bb0055 article-title: Localization of coronary high-intensity signals on T1-weighted MR imaging: relation to plaque morphology and clinical severity of angina pectoris publication-title: JACC Cardiovasc. Imaging doi: 10.1016/j.jcmg.2015.06.013 – volume: 57 start-page: 2516 year: 2011 ident: 10.1016/j.jconrel.2019.03.025_bb0160 article-title: Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2011.02.036 – volume: 7 start-page: 560 year: 2014 ident: 10.1016/j.jconrel.2019.03.025_bb0155 publication-title: Circ. Cardiovasc. Interv. doi: 10.1161/CIRCINTERVENTIONS.114.001498 – volume: 7 start-page: 40 year: 2017 ident: 10.1016/j.jconrel.2019.03.025_bb0040 article-title: Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 111In-tilmanocept publication-title: EJNMMI Res. doi: 10.1186/s13550-017-0287-y – volume: 11 start-page: E754 year: 2018 ident: 10.1016/j.jconrel.2019.03.025_bb0320 article-title: The multifaceted uses and therapeutic advantages of nanoparticles for atherosclerosis research publication-title: Materials doi: 10.3390/ma11050754 – volume: 281 start-page: 21216 year: 2006 ident: 10.1016/j.jconrel.2019.03.025_bb0170 article-title: Reduction in ABCG1 in type 2 diabetic mice increases macrophage foam cell formation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M510952200 – volume: 124 start-page: 196 year: 2002 ident: 10.1016/j.jconrel.2019.03.025_bb0185 article-title: Dimers of dipyrrometheneboron difluoride (BODIPY) with light spectroscopic applications in chemistry and biology publication-title: J. Am. Chem. Soc. doi: 10.1021/ja010983f – volume: 284 start-page: 213 year: 2018 ident: 10.1016/j.jconrel.2019.03.025_bb0240 article-title: The effect of light sensitizer localization on the stability of indocyanine green liposomes publication-title: J. Control. Release doi: 10.1016/j.jconrel.2018.06.029 – volume: 10 start-page: 835 year: 2011 ident: 10.1016/j.jconrel.2019.03.025_bb0310 article-title: Perspectives and opportunities for nanomedicine in the management of atherosclerosis publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd3578 – volume: 86 start-page: 3J year: 2000 ident: 10.1016/j.jconrel.2019.03.025_bb0035 article-title: Coronary artery injury and the biology of atherosclerosis: inflammation, thrombosis, and stabilization publication-title: Am. J. Cardiol. doi: 10.1016/S0002-9149(00)01339-4 – volume: 258 start-page: 468 year: 1992 ident: 10.1016/j.jconrel.2019.03.025_bb0290 article-title: Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E publication-title: Science doi: 10.1126/science.1411543 – volume: 59 start-page: 1539 year: 2012 ident: 10.1016/j.jconrel.2019.03.025_bb0075 article-title: Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2011.12.037 – volume: 53 start-page: 55 year: 2012 ident: 10.1016/j.jconrel.2019.03.025_bb0090 article-title: What can be seen by 18F-FDG PET in atherosclerosis imaging? The effect of foam cell formation on 18F-FDG uptake to macrophages in vitro publication-title: J. Nucl. Med. doi: 10.2967/jnumed.111.092866 – volume: 45 start-page: 1245 year: 2004 ident: 10.1016/j.jconrel.2019.03.025_bb0085 article-title: 18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study publication-title: J. Nucl. Med. – volume: 20 start-page: 4629 year: 2001 ident: 10.1016/j.jconrel.2019.03.025_bb0270 article-title: Lysosomal cysteine proteases: facts and opportunities publication-title: EMBO J. doi: 10.1093/emboj/20.17.4629 – volume: 23 start-page: 809 year: 1994 ident: 10.1016/j.jconrel.2019.03.025_bb0025 article-title: Triggers, acute risk factors and vulnerable plaques: the lexicon of a new frontier publication-title: J. Am. Coll. Cardiol. doi: 10.1016/0735-1097(94)90772-2 – volume: 5 start-page: a009076 year: 2013 ident: 10.1016/j.jconrel.2019.03.025_bb0205 article-title: Biology of the TAM receptors publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a009076 – volume: 417 start-page: 182 year: 2002 ident: 10.1016/j.jconrel.2019.03.025_bb0200 article-title: Identification of a factor that links apoptotic cells to phagocytes publication-title: Nature doi: 10.1038/417182a – volume: 6 start-page: 1250 year: 2013 ident: 10.1016/j.jconrel.2019.03.025_bb0070 article-title: Measurement of arterial activity on routine FDG PET/CT images improves prediction of risk of future CV events publication-title: JACC Cardiovasc. Imaging doi: 10.1016/j.jcmg.2013.08.006 – volume: 114 start-page: 1852 year: 2014 ident: 10.1016/j.jconrel.2019.03.025_bb0020 article-title: Mechanisms of plaque formation and rupture publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.114.302721 – volume: 257 start-page: 2 year: 2017 ident: 10.1016/j.jconrel.2019.03.025_bb0235 article-title: Therapeutic efficacy of combined PEGylated liposomal doxorubicin and radiofrequency ablation: comparing single and combined therapy in young and old mice publication-title: J. Control. Release doi: 10.1016/j.jconrel.2017.02.018 – volume: 11 year: 2016 ident: 10.1016/j.jconrel.2019.03.025_bb0145 article-title: Cathepsin activity-based probes and inhibitor for preclinical atherosclerosis imaging and macrophage depletion publication-title: PLoS One doi: 10.1371/journal.pone.0160522 – volume: 25 start-page: 639 year: 2015 ident: 10.1016/j.jconrel.2019.03.025_bb0165 article-title: An apoptotic 'Eat me' signal: phosphatidylserine exposure publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2015.08.003 – volume: 1240 start-page: 257 year: 1995 ident: 10.1016/j.jconrel.2019.03.025_bb0250 article-title: Loading of amphipathic weak acids into liposomes in response to transmembrane calcium acetate gradients publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(95)00214-6 – volume: 35 start-page: 445 year: 2011 ident: 10.1016/j.jconrel.2019.03.025_bb0225 article-title: Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways publication-title: Immunity doi: 10.1016/j.immuni.2011.09.004 – volume: 383 start-page: 705 year: 2014 ident: 10.1016/j.jconrel.2019.03.025_bb0080 article-title: 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial publication-title: Lancet doi: 10.1016/S0140-6736(13)61754-7 – volume: 110 start-page: 2620 year: 2010 ident: 10.1016/j.jconrel.2019.03.025_bb0110 article-title: New strategies for fluorescent probe design in medical diagnostic imaging publication-title: Chem. Rev. doi: 10.1021/cr900263j – volume: 161 start-page: 939 year: 2002 ident: 10.1016/j.jconrel.2019.03.025_bb0115 article-title: Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)64254-X – volume: 29 start-page: 1444 year: 2009 ident: 10.1016/j.jconrel.2019.03.025_bb0140 article-title: Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.109.193086 – volume: 21 start-page: 37 year: 2006 ident: 10.1016/j.jconrel.2019.03.025_bb0230 article-title: Pharmacokinetic analysis of the uptake of liposomes by macrophages and foam cells in vitro and their distribution to atherosclerotic lesions in mice publication-title: Drug Metab. Pharmacokinet. doi: 10.2133/dmpk.21.37 – volume: 122 start-page: 957 year: 1966 ident: 10.1016/j.jconrel.2019.03.025_bb0260 article-title: Binding of sulfobromophthalein (BSP) sodium and indocyanine green (ICG) by plasma alpha-1 lipoproteins publication-title: Proc. Soc. Exp. Biol. Med. doi: 10.3181/00379727-122-31299 – volume: 55 start-page: 115 year: 2014 ident: 10.1016/j.jconrel.2019.03.025_bb0100 article-title: Development of 111In-labeled liposomes for vulnerable atherosclerotic plaque imaging publication-title: J. Nucl. Med. doi: 10.2967/jnumed.113.123158 – volume: 55 start-page: 2527 year: 2010 ident: 10.1016/j.jconrel.2019.03.025_bb0065 article-title: Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time? publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2009.12.061 – volume: 79 start-page: 896 year: 2006 ident: 10.1016/j.jconrel.2019.03.025_bb0215 article-title: Recognition ligands on apoptotic cells: a perspective publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.1005550 – volume: 34 start-page: 602 year: 2008 ident: 10.1016/j.jconrel.2019.03.025_bb0255 article-title: Preparation, characterization, and evaluation of liposomal ferulic acid in vitro and in vivo publication-title: Drug Dev. Ind. Pharm. doi: 10.1080/03639040701833559 – volume: 42 start-page: 373 year: 2013 ident: 10.1016/j.jconrel.2019.03.025_bb0180 article-title: Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy (review) publication-title: Int. J. Oncol. doi: 10.3892/ijo.2012.1754 – volume: 31 start-page: 199 year: 2010 ident: 10.1016/j.jconrel.2019.03.025_bb0305 article-title: Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2010.01.003 – volume: 1103 start-page: 185 year: 1992 ident: 10.1016/j.jconrel.2019.03.025_bb0265 article-title: Recognition of liposomes by cells: in vitro binding and endocytosis mediated by specific lipid headgroups and surface charge density publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(92)90086-2 – volume: 317 start-page: 223 year: 2004 ident: 10.1016/j.jconrel.2019.03.025_bb0300 article-title: Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2004.03.037 – volume: 284 start-page: 1455 year: 2017 ident: 10.1016/j.jconrel.2019.03.025_bb0130 article-title: Cysteine proteases in atherosclerosis publication-title: FEBS J. doi: 10.1111/febs.14043 – volume: 6 start-page: 163 year: 2016 ident: 10.1016/j.jconrel.2019.03.025_bb0125 article-title: The function of cathepsins B, D, and X in atherosclerosis publication-title: Am. J. Cardiovasc. Dis. |
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