Scleral biomechanics in the aging monkey eye
To investigate the age-related differences in the inhomogeneous, anisotropic, nonlinear biomechanical properties of posterior sclera from old (22.9 +/- 5.3 years) and young (1.5 +/- 0.7 years) rhesus monkeys. The posterior scleral shell of each eye was mounted on a custom-built pressurization appara...
Saved in:
| Published in: | Investigative ophthalmology & visual science Vol. 50; no. 11; p. 5226 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
01.11.2009
|
| Subjects: | |
| ISSN: | 1552-5783, 1552-5783 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | To investigate the age-related differences in the inhomogeneous, anisotropic, nonlinear biomechanical properties of posterior sclera from old (22.9 +/- 5.3 years) and young (1.5 +/- 0.7 years) rhesus monkeys.
The posterior scleral shell of each eye was mounted on a custom-built pressurization apparatus, then intraocular pressure (IOP) was elevated from 5 to 45 mm Hg while the 3D displacements of the scleral surface were measured with speckle interferometry. Each scleral shell's geometry was digitally reconstructed from data generated by a 3-D digitizer (topography) and 20-MHz ultrasound (thickness). An inverse finite element (FE) method incorporating a fiber-reinforced constitutive model was used to extract a unique set of biomechanical properties for each eye. Displacements, thickness, stress, strain, tangent modulus, structural stiffness, and preferred collagen fiber orientation were mapped for each posterior sclera.
The model yielded 3-D deformations of posterior sclera that matched well with those observed experimentally. The posterior sclera exhibited inhomogeneous, anisotropic, nonlinear mechanical behavior. The sclera was significantly thinner (P = 0.038) and tangent modulus and structural stiffness were significantly higher in old monkeys (P < 0.0001). On average, scleral collagen fibers were circumferentially oriented around the optic nerve head (ONH). No difference was found in the preferred collagen fiber orientation and fiber concentration factor between age groups.
Posterior sclera of old monkeys is significantly stiffer than that of young monkeys and is therefore subject to higher stresses but lower strains at all levels of IOP. Age-related stiffening of the sclera may significantly influence ONH biomechanics and potentially contribute to age-related susceptibility to glaucomatous vision loss. |
|---|---|
| AbstractList | To investigate the age-related differences in the inhomogeneous, anisotropic, nonlinear biomechanical properties of posterior sclera from old (22.9 +/- 5.3 years) and young (1.5 +/- 0.7 years) rhesus monkeys.
The posterior scleral shell of each eye was mounted on a custom-built pressurization apparatus, then intraocular pressure (IOP) was elevated from 5 to 45 mm Hg while the 3D displacements of the scleral surface were measured with speckle interferometry. Each scleral shell's geometry was digitally reconstructed from data generated by a 3-D digitizer (topography) and 20-MHz ultrasound (thickness). An inverse finite element (FE) method incorporating a fiber-reinforced constitutive model was used to extract a unique set of biomechanical properties for each eye. Displacements, thickness, stress, strain, tangent modulus, structural stiffness, and preferred collagen fiber orientation were mapped for each posterior sclera.
The model yielded 3-D deformations of posterior sclera that matched well with those observed experimentally. The posterior sclera exhibited inhomogeneous, anisotropic, nonlinear mechanical behavior. The sclera was significantly thinner (P = 0.038) and tangent modulus and structural stiffness were significantly higher in old monkeys (P < 0.0001). On average, scleral collagen fibers were circumferentially oriented around the optic nerve head (ONH). No difference was found in the preferred collagen fiber orientation and fiber concentration factor between age groups.
Posterior sclera of old monkeys is significantly stiffer than that of young monkeys and is therefore subject to higher stresses but lower strains at all levels of IOP. Age-related stiffening of the sclera may significantly influence ONH biomechanics and potentially contribute to age-related susceptibility to glaucomatous vision loss. To investigate the age-related differences in the inhomogeneous, anisotropic, nonlinear biomechanical properties of posterior sclera from old (22.9 +/- 5.3 years) and young (1.5 +/- 0.7 years) rhesus monkeys.PURPOSETo investigate the age-related differences in the inhomogeneous, anisotropic, nonlinear biomechanical properties of posterior sclera from old (22.9 +/- 5.3 years) and young (1.5 +/- 0.7 years) rhesus monkeys.The posterior scleral shell of each eye was mounted on a custom-built pressurization apparatus, then intraocular pressure (IOP) was elevated from 5 to 45 mm Hg while the 3D displacements of the scleral surface were measured with speckle interferometry. Each scleral shell's geometry was digitally reconstructed from data generated by a 3-D digitizer (topography) and 20-MHz ultrasound (thickness). An inverse finite element (FE) method incorporating a fiber-reinforced constitutive model was used to extract a unique set of biomechanical properties for each eye. Displacements, thickness, stress, strain, tangent modulus, structural stiffness, and preferred collagen fiber orientation were mapped for each posterior sclera.METHODSThe posterior scleral shell of each eye was mounted on a custom-built pressurization apparatus, then intraocular pressure (IOP) was elevated from 5 to 45 mm Hg while the 3D displacements of the scleral surface were measured with speckle interferometry. Each scleral shell's geometry was digitally reconstructed from data generated by a 3-D digitizer (topography) and 20-MHz ultrasound (thickness). An inverse finite element (FE) method incorporating a fiber-reinforced constitutive model was used to extract a unique set of biomechanical properties for each eye. Displacements, thickness, stress, strain, tangent modulus, structural stiffness, and preferred collagen fiber orientation were mapped for each posterior sclera.The model yielded 3-D deformations of posterior sclera that matched well with those observed experimentally. The posterior sclera exhibited inhomogeneous, anisotropic, nonlinear mechanical behavior. The sclera was significantly thinner (P = 0.038) and tangent modulus and structural stiffness were significantly higher in old monkeys (P < 0.0001). On average, scleral collagen fibers were circumferentially oriented around the optic nerve head (ONH). No difference was found in the preferred collagen fiber orientation and fiber concentration factor between age groups.RESULTSThe model yielded 3-D deformations of posterior sclera that matched well with those observed experimentally. The posterior sclera exhibited inhomogeneous, anisotropic, nonlinear mechanical behavior. The sclera was significantly thinner (P = 0.038) and tangent modulus and structural stiffness were significantly higher in old monkeys (P < 0.0001). On average, scleral collagen fibers were circumferentially oriented around the optic nerve head (ONH). No difference was found in the preferred collagen fiber orientation and fiber concentration factor between age groups.Posterior sclera of old monkeys is significantly stiffer than that of young monkeys and is therefore subject to higher stresses but lower strains at all levels of IOP. Age-related stiffening of the sclera may significantly influence ONH biomechanics and potentially contribute to age-related susceptibility to glaucomatous vision loss.CONCLUSIONSPosterior sclera of old monkeys is significantly stiffer than that of young monkeys and is therefore subject to higher stresses but lower strains at all levels of IOP. Age-related stiffening of the sclera may significantly influence ONH biomechanics and potentially contribute to age-related susceptibility to glaucomatous vision loss. |
| Author | Girard, Michaël J A Suh, J-K Francis Bottlang, Michael Burgoyne, Claude F Downs, J Crawford |
| Author_xml | – sequence: 1 givenname: Michaël J A surname: Girard fullname: Girard, Michaël J A organization: Ocular Biomechanics Laboratory, Devers Eye Institute, Portland, Oregon 97232, USA – sequence: 2 givenname: J-K Francis surname: Suh fullname: Suh, J-K Francis – sequence: 3 givenname: Michael surname: Bottlang fullname: Bottlang, Michael – sequence: 4 givenname: Claude F surname: Burgoyne fullname: Burgoyne, Claude F – sequence: 5 givenname: J Crawford surname: Downs fullname: Downs, J Crawford |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19494203$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNj0tLw0AURgep2IfuXEt2bky9c-8kM1lKqQ8ouFDXYTK5bUeTSc2kQv-9ghVcnW9x-OBMxSh0gYW4lDCXMte3vvuKczApUU4nYiKzDNNMGxr922MxjfEdAKVEOBNjWahCIdBE3Ly4hnvbJJXvWnZbG7yLiQ_JsOXEbnzYJG0XPviQ8IHPxenaNpEvjpyJt_vl6-IxXT0_PC3uVqlTKhtSbbSCtUNtcl2DU1jnhqQsrEa2GRcEaDNYa6iNqfKqYDJGs3IAhtCqHGfi-vd313efe45D2frouGls4G4fS01ECqnAH_PqaO6rluty1_vW9ofyLxC_AUnxUVs |
| CitedBy_id | crossref_primary_10_1167_iovs_19_26777 crossref_primary_10_1167_iovs_18_25111 crossref_primary_10_1016_j_ophtha_2011_02_041 crossref_primary_10_1016_j_mbs_2014_08_002 crossref_primary_10_1167_iovs_64_5_30 crossref_primary_10_1016_j_jbiomech_2013_12_009 crossref_primary_10_1111_opo_13122 crossref_primary_10_3389_fphys_2020_00682 crossref_primary_10_1016_j_ajo_2011_05_006 crossref_primary_10_3389_fbioe_2023_1146828 crossref_primary_10_1038_s41598_019_43048_2 crossref_primary_10_1007_s10237_011_0326_y crossref_primary_10_1016_j_exer_2014_08_016 crossref_primary_10_1109_TMI_2014_2312133 crossref_primary_10_1080_02713683_2019_1629594 crossref_primary_10_1167_iovs_19_27060 crossref_primary_10_1111_aos_13070 crossref_primary_10_1016_j_exer_2017_08_015 crossref_primary_10_1097_ICU_0000000000000354 crossref_primary_10_1167_tvst_14_3_20 crossref_primary_10_1016_j_exer_2015_06_005 crossref_primary_10_3341_kjo_2021_0133 crossref_primary_10_1007_s10237_013_0517_9 crossref_primary_10_4103_IJO_IJO_444_24 crossref_primary_10_1016_j_exer_2011_11_017 crossref_primary_10_1016_j_jmbbm_2019_103560 crossref_primary_10_1038_s41598_022_26520_4 crossref_primary_10_1016_j_jmbbm_2017_10_024 crossref_primary_10_1038_s41598_019_43206_6 crossref_primary_10_1167_iovs_64_5_25 crossref_primary_10_1016_j_exer_2016_08_022 crossref_primary_10_1016_j_exer_2020_107978 crossref_primary_10_1136_bjophthalmol_2020_318246 crossref_primary_10_1016_j_jmbbm_2019_103562 crossref_primary_10_1016_j_exer_2013_12_008 crossref_primary_10_1016_j_exer_2015_05_024 crossref_primary_10_1016_j_ophtha_2012_05_012 crossref_primary_10_1016_j_ophtha_2018_05_011 crossref_primary_10_1371_journal_pone_0111879 crossref_primary_10_1097_OPX_0000000000002065 crossref_primary_10_1167_iovs_61_5_16 crossref_primary_10_1167_iovs_65_13_54 crossref_primary_10_1016_j_preteyeres_2017_03_001 crossref_primary_10_1016_j_visres_2025_108592 crossref_primary_10_1016_j_ophtha_2024_02_008 crossref_primary_10_1016_j_survophthal_2017_06_007 crossref_primary_10_1007_s10237_012_0455_y crossref_primary_10_3390_ijms24032573 crossref_primary_10_1167_iovs_61_4_3 crossref_primary_10_1167_iovs_64_15_19 crossref_primary_10_1016_j_jbiomech_2021_110911 crossref_primary_10_1016_j_exer_2010_09_009 crossref_primary_10_3389_fbioe_2019_00105 crossref_primary_10_1259_bjr_20150429 crossref_primary_10_1097_IJG_0000000000001573 crossref_primary_10_1167_iovs_18_23885 crossref_primary_10_1016_j_exer_2015_02_011 crossref_primary_10_1371_journal_pone_0240724 crossref_primary_10_1016_j_exer_2014_07_004 crossref_primary_10_1371_journal_pone_0156466 crossref_primary_10_1007_s10237_010_0240_8 crossref_primary_10_1016_j_ophtha_2016_02_008 crossref_primary_10_1016_j_exer_2011_09_018 crossref_primary_10_1016_j_preteyeres_2019_100773 crossref_primary_10_1016_j_optlaseng_2015_07_013 crossref_primary_10_1016_j_jbiomech_2019_109438 crossref_primary_10_1136_bjophthalmol_2020_317900 crossref_primary_10_1080_10255842_2011_641119 crossref_primary_10_53432_2078_4104_2025_24_3_76_88 crossref_primary_10_1016_j_jmbbm_2013_03_027 crossref_primary_10_1167_iovs_19_26600 crossref_primary_10_1155_2015_141598 crossref_primary_10_1007_s10237_020_01333_4 crossref_primary_10_1097_IJG_0000000000000826 crossref_primary_10_1186_s40662_016_0052_8 crossref_primary_10_1016_j_exer_2020_108188 crossref_primary_10_1016_j_exer_2015_07_015 crossref_primary_10_1371_journal_pone_0131396 crossref_primary_10_1016_j_coph_2012_09_001 crossref_primary_10_1016_j_actbio_2021_04_042 crossref_primary_10_1038_srep33796 crossref_primary_10_1007_s10792_021_02021_7 crossref_primary_10_1167_iovs_17_22069 crossref_primary_10_3390_life10120316 crossref_primary_10_1016_j_ultras_2020_106263 crossref_primary_10_1038_s41598_018_21203_5 crossref_primary_10_1016_j_ajo_2019_06_019 crossref_primary_10_1038_s41433_024_03569_1 crossref_primary_10_1167_iovs_61_4_27 crossref_primary_10_1111_aos_12963 crossref_primary_10_1371_journal_pone_0214770 crossref_primary_10_1016_j_actbio_2020_06_026 crossref_primary_10_1371_journal_pone_0029692 crossref_primary_10_1111_vop_12923 crossref_primary_10_1109_TMI_2015_2504440 crossref_primary_10_1016_j_preteyeres_2021_101021 crossref_primary_10_3109_02713683_2014_914543 crossref_primary_10_1097_APO_0000000000000179 crossref_primary_10_3390_bioengineering10080920 crossref_primary_10_1167_iovs_65_8_48 crossref_primary_10_1016_j_jbiomech_2018_03_017 crossref_primary_10_1167_iovs_17_23454 crossref_primary_10_1016_j_exer_2020_108202 crossref_primary_10_1016_j_exer_2023_109510 crossref_primary_10_1167_iovs_63_5_24 crossref_primary_10_1016_j_jmbbm_2012_10_011 crossref_primary_10_1586_eop_10_30 crossref_primary_10_1016_j_ophtha_2022_11_009 crossref_primary_10_1007_s00441_013_1603_0 crossref_primary_10_1007_s10237_022_01590_5 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1167/iovs.08-3363 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1552-5783 |
| ExternalDocumentID | 19494203 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NEI NIH HHS grantid: R01EY11610 – fundername: NEI NIH HHS grantid: R01 EY011610 |
| GroupedDBID | --- .55 .GJ 18M 2WC 34G 39C 53G 5GY 5RE ACGFO ACNCT ADBBV AENEX AFFNX AFOSN AI. ALMA_UNASSIGNED_HOLDINGS BAWUL CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P GROUPED_DOAJ GX1 N9A NPM OK1 P2P RPM SJN TR2 TRV VH1 W8F WH7 WOQ WOW X7M ZGI ZXP 7X8 |
| ID | FETCH-LOGICAL-c445t-78740fc27867d0c42d683119a72ea5e9302a50f70d88b6b9e3887e4c00832a462 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 176 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000271429200028&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1552-5783 |
| IngestDate | Thu Sep 04 17:22:37 EDT 2025 Fri May 30 11:02:19 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c445t-78740fc27867d0c42d683119a72ea5e9302a50f70d88b6b9e3887e4c00832a462 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/2883469 |
| PMID | 19494203 |
| PQID | 733342392 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_733342392 pubmed_primary_19494203 |
| PublicationCentury | 2000 |
| PublicationDate | 2009-11-01 |
| PublicationDateYYYYMMDD | 2009-11-01 |
| PublicationDate_xml | – month: 11 year: 2009 text: 2009-11-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Investigative ophthalmology & visual science |
| PublicationTitleAlternate | Invest Ophthalmol Vis Sci |
| PublicationYear | 2009 |
| SSID | ssj0021120 |
| Score | 2.4144866 |
| Snippet | To investigate the age-related differences in the inhomogeneous, anisotropic, nonlinear biomechanical properties of posterior sclera from old (22.9 +/- 5.3... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 5226 |
| SubjectTerms | Aging - physiology Animals Anisotropy Biomechanical Phenomena Collagen - metabolism Elasticity Female Imaging, Three-Dimensional Intraocular Pressure - physiology Macaca mulatta - physiology Male Sclera - physiology |
| Title | Scleral biomechanics in the aging monkey eye |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/19494203 https://www.proquest.com/docview/733342392 |
| Volume | 50 |
| WOSCitedRecordID | wos000271429200028&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwED4BRYiF96O85IER08R2YntCCFEx0KoSD3WLEj-kLEnblEr8e2w37YYYWDJYSWSdz-c7f3f3Ady6I1AKoxNMDC0wi7XFwkUF2OrI2iRXTAX0_POVD4diPJajNjenadMqVzYxGGpdK39H3uOUhmZ15GEyxZ40yoOrLYPGJnSo82S8UvPxGkRwoU3oyuibjGGnmHSV957yXlkvmnt_M0h9_8_ffMtwxvT3_zm7A9hrnUv0uNSGQ9gw1RHsDFr4_Bju3tzwzL0Riu59zW-pGlRWyHmBKNAVIfcnt62R-TYn8NF_fn96wS1dAlaMJXPMPbueVYSLlOtIMaJTQeNY5pyYPDGSRiRPIssjLUSRFtJQZ2AMU94LIzlLySlsVXVlzgFJyoqYFEoUWvuARRItbEJypQxhVssuoJUYMqeOHmPIK1N_NdlaEF04W4oymyzbZmSxZJKRiF78_fEl7AbUJtT8XUHHuq1ormFbLeZlM7sJy-yew9HgByWJsIc |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Scleral+biomechanics+in+the+aging+monkey+eye&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.au=Girard%2C+Micha%C3%ABl+J+A&rft.au=Suh%2C+J-K+Francis&rft.au=Bottlang%2C+Michael&rft.au=Burgoyne%2C+Claude+F&rft.date=2009-11-01&rft.issn=1552-5783&rft.eissn=1552-5783&rft.volume=50&rft.issue=11&rft.spage=5226&rft_id=info:doi/10.1167%2Fiovs.08-3363&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1552-5783&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1552-5783&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1552-5783&client=summon |