Serum leptin, body fat, and nutritional markers during the six months post-kidney transplantation

Leptin is a 16-kd protein that is thought to be a regulator of food intake and body weight. Many previous studies have reported elevated serum leptin levels in renal failure. In this study, we investigated the outcome of serum leptin and its relationship to body fat (BF), dietary intake, nutritional...

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Published in:	Metabolism, clinical and experimental Vol. 53; no. 5; pp. 614 - 619
Main Authors:	El Haggan, Wael, Chauveau, Philippe, Barthe, Nicole, Merville, Pierre, Potaux, Luc, Aparicio, Michel
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01.05.2004 Elsevier
Subjects:	Adult Albumins - metabolism Biological and medical sciences Biomarkers - blood Body Composition - physiology Body Mass Index C-Reactive Protein - metabolism Cadaver Case-Control Studies Creatinine - blood Energy Intake - physiology Female Humans Kidney Transplantation Leptin - blood Male Medical sciences Metabolic diseases Middle Aged Nutritional Status - physiology Obesity Postoperative Period Prospective Studies Time Factors Transferrin - metabolism Adipocytokine Treatment Nutrition Surgery Leptin Graft Serum Transplantation Marker Fat mass Kidney
ISSN:	0026-0495, 1532-8600
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Abstract	Leptin is a 16-kd protein that is thought to be a regulator of food intake and body weight. Many previous studies have reported elevated serum leptin levels in renal failure. In this study, we investigated the outcome of serum leptin and its relationship to body fat (BF), dietary intake, nutritional, and inflammatory markers after kidney transplantation (KTx). A total of 41 kidney transplant recipients were followed-up prospectively during 6 months posttransplantation. Serum leptin, albumin, transferrin, and C-reactive protein (CRP) were measured at KTx, 15 days, 3, and 6 months later. Dietary intake and BF were determined at KTx, 3, and 6 months later. A decrease in serum leptin was observed early at day 15 after KTx; this decrease was significant only in patients with BF ≥ 30% of body weight. The decrease was maintained at 3 and 6 months after KTx. In multivariate analysis, an independent impact of higher percentage BF at KTx on the decrease of serum leptin was observed. Serum leptin correlated positively with BF. Conversely, no correlation was found between changes of serum leptin and changes of dietary intake. Leptin correlated positively with CRP at KTx, but not after normalization of renal function. Changes of serum leptin levels were not correlated with those of serum albumin levels. In summary, hyperleptinemia at KTx is manifest in patients with a high percentage of BF. An early and maintained correction follows KTx. Serum leptin levels did not appear to affect alimentary intake at and after KTx.
AbstractList	Leptin is a 16-kd protein that is thought to be a regulator of food intake and body weight. Many previous studies have reported elevated serum leptin levels in renal failure. In this study, we investigated the outcome of serum leptin and its relationship to body fat (BF), dietary intake, nutritional, and inflammatory markers after kidney transplantation (KTx). A total of 41 kidney transplant recipients were followed-up prospectively during 6 months posttransplantation. Serum leptin, albumin, transferrin, and C-reactive protein (CRP) were measured at KTx, 15 days, 3, and 6 months later. Dietary intake and BF were determined at KTx, 3, and 6 months later. A decrease in serum leptin was observed early at day 15 after KTx; this decrease was significant only in patients with BF >/= 30% of body weight. The decrease was maintained at 3 and 6 months after KTx. In multivariate analysis, an independent impact of higher percentage BF at KTx on the decrease of serum leptin was observed. Serum leptin correlated positively with BF. Conversely, no correlation was found between changes of serum leptin and changes of dietary intake. Leptin correlated positively with CRP at KTx, but not after normalization of renal function. Changes of serum leptin levels were not correlated with those of serum albumin levels. In summary, hyperleptinemia at KTx is manifest in patients with a high percentage of BF. An early and maintained correction follows KTx. Serum leptin levels did not appear to affect alimentary intake at and after KTx.Leptin is a 16-kd protein that is thought to be a regulator of food intake and body weight. Many previous studies have reported elevated serum leptin levels in renal failure. In this study, we investigated the outcome of serum leptin and its relationship to body fat (BF), dietary intake, nutritional, and inflammatory markers after kidney transplantation (KTx). A total of 41 kidney transplant recipients were followed-up prospectively during 6 months posttransplantation. Serum leptin, albumin, transferrin, and C-reactive protein (CRP) were measured at KTx, 15 days, 3, and 6 months later. Dietary intake and BF were determined at KTx, 3, and 6 months later. A decrease in serum leptin was observed early at day 15 after KTx; this decrease was significant only in patients with BF >/= 30% of body weight. The decrease was maintained at 3 and 6 months after KTx. In multivariate analysis, an independent impact of higher percentage BF at KTx on the decrease of serum leptin was observed. Serum leptin correlated positively with BF. Conversely, no correlation was found between changes of serum leptin and changes of dietary intake. Leptin correlated positively with CRP at KTx, but not after normalization of renal function. Changes of serum leptin levels were not correlated with those of serum albumin levels. In summary, hyperleptinemia at KTx is manifest in patients with a high percentage of BF. An early and maintained correction follows KTx. Serum leptin levels did not appear to affect alimentary intake at and after KTx. Leptin is a 16-kd protein that is thought to be a regulator of food intake and body weight. Many previous studies have reported elevated serum leptin levels in renal failure. In this study, we investigated the outcome of serum leptin and its relationship to body fat (BF), dietary intake, nutritional, and inflammatory markers after kidney transplantation (KTx). A total of 41 kidney transplant recipients were followed-up prospectively during 6 months posttransplantation. Serum leptin, albumin, transferrin, and C-reactive protein (CRP) were measured at KTx, 15 days, 3, and 6 months later. Dietary intake and BF were determined at KTx, 3, and 6 months later. A decrease in serum leptin was observed early at day 15 after KTx; this decrease was significant only in patients with BF ≥ 30% of body weight. The decrease was maintained at 3 and 6 months after KTx. In multivariate analysis, an independent impact of higher percentage BF at KTx on the decrease of serum leptin was observed. Serum leptin correlated positively with BF. Conversely, no correlation was found between changes of serum leptin and changes of dietary intake. Leptin correlated positively with CRP at KTx, but not after normalization of renal function. Changes of serum leptin levels were not correlated with those of serum albumin levels. In summary, hyperleptinemia at KTx is manifest in patients with a high percentage of BF. An early and maintained correction follows KTx. Serum leptin levels did not appear to affect alimentary intake at and after KTx. Leptin is a 16-kd protein that is thought to be a regulator of food intake and body weight. Many previous studies have reported elevated serum leptin levels in renal failure. In this study, we investigated the outcome of serum leptin and its relationship to body fat (BF), dietary intake, nutritional, and inflammatory markers after kidney transplantation (KTx). A total of 41 kidney transplant recipients were followed-up prospectively during 6 months posttransplantation. Serum leptin, albumin, transferrin, and C-reactive protein (CRP) were measured at KTx, 15 days, 3, and 6 months later. Dietary intake and BF were determined at KTx, 3, and 6 months later. A decrease in serum leptin was observed early at day 15 after KTx; this decrease was significant only in patients with BF >/= 30% of body weight. The decrease was maintained at 3 and 6 months after KTx. In multivariate analysis, an independent impact of higher percentage BF at KTx on the decrease of serum leptin was observed. Serum leptin correlated positively with BF. Conversely, no correlation was found between changes of serum leptin and changes of dietary intake. Leptin correlated positively with CRP at KTx, but not after normalization of renal function. Changes of serum leptin levels were not correlated with those of serum albumin levels. In summary, hyperleptinemia at KTx is manifest in patients with a high percentage of BF. An early and maintained correction follows KTx. Serum leptin levels did not appear to affect alimentary intake at and after KTx.
Author	Potaux, Luc Barthe, Nicole Chauveau, Philippe El Haggan, Wael Merville, Pierre Aparicio, Michel
Author_xml	– sequence: 1 givenname: Wael surname: El Haggan fullname: El Haggan, Wael organization: Department of Nephrology and Renal Transplantation, Bordeaux University Hospital, Bordeaux, France – sequence: 2 givenname: Philippe surname: Chauveau fullname: Chauveau, Philippe organization: Department of Nephrology and Renal Transplantation, Bordeaux University Hospital, Bordeaux, France – sequence: 3 givenname: Nicole surname: Barthe fullname: Barthe, Nicole organization: Laboratory of Nuclear Medicine, Bordeaux University Hospital, Bordeaux, France – sequence: 4 givenname: Pierre surname: Merville fullname: Merville, Pierre organization: Department of Nephrology and Renal Transplantation, Bordeaux University Hospital, Bordeaux, France – sequence: 5 givenname: Luc surname: Potaux fullname: Potaux, Luc organization: Department of Nephrology and Renal Transplantation, Bordeaux University Hospital, Bordeaux, France – sequence: 6 givenname: Michel surname: Aparicio fullname: Aparicio, Michel organization: Department of Nephrology and Renal Transplantation, Bordeaux University Hospital, Bordeaux, France
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Cites_doi	10.1093/ndt/14.2.400 10.1159/000045781 10.1016/S0272-6386(99)70038-7 10.1053/ajkd.1998.v31.pm9531182 10.1038/ki.1997.269 10.1093/ndt/14.3.732 10.1042/cs0930119 10.1681/ASN.V891423 10.1016/S0969-8043(97)00226-1 10.1681/ASN.V961080 10.1159/000045122 10.1093/ajcn/69.1.18 10.1093/ndt/12.11.2318 10.1177/089686089801800603 10.1159/000013421 10.1038/27376 10.1016/S0140-6736(97)06348-4 10.1093/ndt/13.9.2271 10.1046/j.1525-1594.1999.06279.x 10.1093/ndt/13.9.2276 10.1681/ASN.V961074 10.1159/000180580
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Snippet	Leptin is a 16-kd protein that is thought to be a regulator of food intake and body weight. Many previous studies have reported elevated serum leptin levels in...
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SubjectTerms	Adult Albumins - metabolism Biological and medical sciences Biomarkers - blood Body Composition - physiology Body Mass Index C-Reactive Protein - metabolism Cadaver Case-Control Studies Creatinine - blood Energy Intake - physiology Female Humans Kidney Transplantation Leptin - blood Male Medical sciences Metabolic diseases Middle Aged Nutritional Status - physiology Obesity Postoperative Period Prospective Studies Time Factors Transferrin - metabolism
Title	Serum leptin, body fat, and nutritional markers during the six months post-kidney transplantation
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