Serum leptin, body fat, and nutritional markers during the six months post-kidney transplantation

Leptin is a 16-kd protein that is thought to be a regulator of food intake and body weight. Many previous studies have reported elevated serum leptin levels in renal failure. In this study, we investigated the outcome of serum leptin and its relationship to body fat (BF), dietary intake, nutritional...

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Veröffentlicht in:Metabolism, clinical and experimental Jg. 53; H. 5; S. 614 - 619
Hauptverfasser: El Haggan, Wael, Chauveau, Philippe, Barthe, Nicole, Merville, Pierre, Potaux, Luc, Aparicio, Michel
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York, NY Elsevier Inc 01.05.2004
Elsevier
Schlagworte:
Adult
Albumins - metabolism
Biological and medical sciences
Biomarkers - blood
Body Composition - physiology
Body Mass Index
C-Reactive Protein - metabolism
Cadaver
Case-Control Studies
Creatinine - blood
Energy Intake - physiology
Female
Humans
Kidney Transplantation
Leptin - blood
Male
Medical sciences
Metabolic diseases
Middle Aged
Nutritional Status - physiology
Obesity
Postoperative Period
Prospective Studies
Time Factors
Transferrin - metabolism
Adipocytokine
Treatment
Nutrition
Surgery
Leptin
Graft
Serum
Transplantation
Marker
Fat mass
Kidney
ISSN:0026-0495, 1532-8600
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Zusammenfassung:Leptin is a 16-kd protein that is thought to be a regulator of food intake and body weight. Many previous studies have reported elevated serum leptin levels in renal failure. In this study, we investigated the outcome of serum leptin and its relationship to body fat (BF), dietary intake, nutritional, and inflammatory markers after kidney transplantation (KTx). A total of 41 kidney transplant recipients were followed-up prospectively during 6 months posttransplantation. Serum leptin, albumin, transferrin, and C-reactive protein (CRP) were measured at KTx, 15 days, 3, and 6 months later. Dietary intake and BF were determined at KTx, 3, and 6 months later. A decrease in serum leptin was observed early at day 15 after KTx; this decrease was significant only in patients with BF ≥ 30% of body weight. The decrease was maintained at 3 and 6 months after KTx. In multivariate analysis, an independent impact of higher percentage BF at KTx on the decrease of serum leptin was observed. Serum leptin correlated positively with BF. Conversely, no correlation was found between changes of serum leptin and changes of dietary intake. Leptin correlated positively with CRP at KTx, but not after normalization of renal function. Changes of serum leptin levels were not correlated with those of serum albumin levels. In summary, hyperleptinemia at KTx is manifest in patients with a high percentage of BF. An early and maintained correction follows KTx. Serum leptin levels did not appear to affect alimentary intake at and after KTx.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2003.10.034