Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

Whole-exome sequencing was performed on four patients' tumors before exposure to pembrolizumab and after disease progression following a response to treatment. Acquired mutations involving antigen presentation and interferon response were noted. Durable responses in metastatic cancers have been...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 375; no. 9; pp. 819 - 829
Main Authors:	Zaretsky, Jesse M, Garcia-Diaz, Angel, Shin, Daniel S, Escuin-Ordinas, Helena, Hugo, Willy, Hu-Lieskovan, Siwen, Torrejon, Davis Y, Abril-Rodriguez, Gabriel, Sandoval, Salemiz, Barthly, Lucas, Saco, Justin, Homet Moreno, Blanca, Mezzadra, Riccardo, Chmielowski, Bartosz, Ruchalski, Kathleen, Shintaku, I. Peter, Sanchez, Phillip J, Puig-Saus, Cristina, Cherry, Grace, Seja, Elizabeth, Kong, Xiangju, Pang, Jia, Berent-Maoz, Beata, Comin-Anduix, Begoña, Graeber, Thomas G, Tumeh, Paul C, Schumacher, Ton N.M, Lo, Roger S, Ribas, Antoni
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 01.09.2016
Subjects:	Antibodies, Monoclonal, Humanized - therapeutic use Antigen presentation Antigens Antineoplastic Agents - therapeutic use Apoptosis beta 2-Microglobulin - genetics Biopsy Cancer Clonal deletion Clonal selection Drug Resistance, Neoplasm - genetics Exome Gene deletion Gene Expression Regulation, Neoplastic Genes, MHC Class I Humans Immunotherapy Interferon-gamma - therapeutic use Janus kinase Janus Kinase 1 - genetics Janus kinase 2 Janus Kinase 2 - genetics Major histocompatibility complex Melanoma Melanoma - drug therapy Melanoma - genetics Melanoma - secondary Metastases Metastasis Monoclonal antibodies Mutation PD-1 protein Pembrolizumab Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism Recurrence Sequence Analysis, DNA Signal Transduction Targeted cancer therapy Tumors Los Angeles California United States > US
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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