Mesothelin-Associated Anti-Senescence Through P53 in Pancreatic Ductal Adenocarcinoma

Objectives: Mesothelin (MSLN) is overexpressed in pancreatic ductal adenocarcinoma (PDAC), promoting cell proliferation, migration, and inhibiting apoptosis. While its oncogenic properties have been documented, the role of MSLN in regulating cellular senescence—a tumor-suppressive mechanism—has rema...

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Bibliographic Details
Published in:	Cancers Vol. 17; no. 12; p. 2058
Main Authors:	Liu, Dongliang, Lu, Jianming, Chen, Changyi, Yao, Qizhi
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 19.06.2025 MDPI
Subjects:	Adenocarcinoma Aging Apoptosis Cancer Care and treatment Cell death Cell migration Cell proliferation Cell viability Cells Cloning Cyclin-dependent kinase inhibitor p21 Cytotoxicity Development and progression DNA damage DNA repair Enzyme-linked immunosorbent assay Enzymes Gene expression Genes Health aspects Immunoblotting INK4a protein Interleukin 8 Medical prognosis Metastasis Oncology, Experimental p16 Protein p53 Protein Pancreatic cancer Phenotypes Potassium Prevention Proteins Proteomics Senescence Tumor proteins Tumors Western blotting United States Maryland Massachusetts Illinois United States > US cellular senescence senescence-associated secretory phenotype interleukin-8 mesothelin pancreatic ductal adenocarcinoma
ISSN:	2072-6694, 2072-6694
Online Access:	Get full text
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