Mesothelin-Associated Anti-Senescence Through P53 in Pancreatic Ductal Adenocarcinoma

Objectives: Mesothelin (MSLN) is overexpressed in pancreatic ductal adenocarcinoma (PDAC), promoting cell proliferation, migration, and inhibiting apoptosis. While its oncogenic properties have been documented, the role of MSLN in regulating cellular senescence—a tumor-suppressive mechanism—has rema...

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Vydáno v:	Cancers Ročník 17; číslo 12; s. 2058
Hlavní autoři:	Liu, Dongliang, Lu, Jianming, Chen, Changyi, Yao, Qizhi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 19.06.2025 MDPI
Témata:	Adenocarcinoma Aging Apoptosis Cancer Care and treatment Cell death Cell migration Cell proliferation Cell viability Cells Cloning Cyclin-dependent kinase inhibitor p21 Cytotoxicity Development and progression DNA damage DNA repair Enzyme-linked immunosorbent assay Enzymes Gene expression Genes Health aspects Immunoblotting INK4a protein Interleukin 8 Medical prognosis Metastasis Oncology, Experimental p16 Protein p53 Protein Pancreatic cancer Phenotypes Potassium Prevention Proteins Proteomics Senescence Tumor proteins Tumors Western blotting United States Maryland Massachusetts Illinois United States > US cellular senescence senescence-associated secretory phenotype interleukin-8 mesothelin pancreatic ductal adenocarcinoma
ISSN:	2072-6694, 2072-6694
On-line přístup:	Získat plný text
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