Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis

The cellular demand for cholesterol requires control of its biosynthesis by the mevalonate pathway. Regulation of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), a rate-limiting enzyme in this pathway and the target of statins, is a key control point herein. Accordingly, HMGCR is subject to...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology Jg. 37; H. 11; S. 2064
Hauptverfasser:	Loregger, Anke, Raaben, Matthijs, Tan, Josephine, Scheij, Saskia, Moeton, Martina, van den Berg, Marlene, Gelberg-Etel, Hila, Stickel, Elmer, Roitelman, Joseph, Brummelkamp, Thijn, Zelcer, Noam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2017
Schlagworte:	Animals Blood Proteins - genetics Blood Proteins - metabolism Cholesterol - biosynthesis CRISPR-Cas Systems Endoplasmic Reticulum - enzymology Enzyme Stability Feedback, Physiological Gene Expression Regulation, Enzymologic Haploidy Hep G2 Cells Hepatocytes - enzymology Humans Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mevalonic Acid - metabolism Microscopy, Confocal Proteasome Endopeptidase Complex - metabolism Protein Transport Proteolysis Rats Recombinant Fusion Proteins - metabolism Transfection Ubiquitination cholesterol sterols hydroxymethylglutaryl CoA reductases mammalian haploid genetics oxysterols
ISSN:	1524-4636, 1524-4636
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