The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life
Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a dis...
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| Published in: | Natural product reports Vol. 31; no. 1; p. 61 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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01.01.2014
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| ISSN: | 1460-4752, 1460-4752 |
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| Abstract | Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily. In the past two decades an increasing number of papers have been published on PPTases ranging from identification, characterization, structure determination, mutagenesis, inhibition, and engineering in synthetic biology. In this review, we comprehensively discuss all current knowledge on this class of enzymes that post-translationally install a 4'-phosphopantetheine arm on various carrier proteins. |
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| AbstractList | Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily. In the past two decades an increasing number of papers have been published on PPTases ranging from identification, characterization, structure determination, mutagenesis, inhibition, and engineering in synthetic biology. In this review, we comprehensively discuss all current knowledge on this class of enzymes that post-translationally install a 4'-phosphopantetheine arm on various carrier proteins. Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily. In the past two decades an increasing number of papers have been published on PPTases ranging from identification, characterization, structure determination, mutagenesis, inhibition, and engineering in synthetic biology. In this review, we comprehensively discuss all current knowledge on this class of enzymes that post-translationally install a 4'-phosphopantetheine arm on various carrier proteins.Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily. In the past two decades an increasing number of papers have been published on PPTases ranging from identification, characterization, structure determination, mutagenesis, inhibition, and engineering in synthetic biology. In this review, we comprehensively discuss all current knowledge on this class of enzymes that post-translationally install a 4'-phosphopantetheine arm on various carrier proteins. |
| Author | Beld, Joris Sonnenschein, Eva C Vickery, Christopher R Noel, Joseph P Burkart, Michael D |
| Author_xml | – sequence: 1 givenname: Joris surname: Beld fullname: Beld, Joris email: mburkart@ucsd.edu organization: Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA. mburkart@ucsd.edu – sequence: 2 givenname: Eva C surname: Sonnenschein fullname: Sonnenschein, Eva C – sequence: 3 givenname: Christopher R surname: Vickery fullname: Vickery, Christopher R – sequence: 4 givenname: Joseph P surname: Noel fullname: Noel, Joseph P – sequence: 5 givenname: Michael D surname: Burkart fullname: Burkart, Michael D |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24292120$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Bacterial Proteins - metabolism Molecular Structure Protein Processing, Post-Translational Transferases (Other Substituted Phosphate Groups) - metabolism |
| Title | The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life |
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