Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α

Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine that can elicit distinct cellular behaviors under different molecular contexts. Mitogen activated protein kinase (MAPK) pathways, especially the extracellular signal-regulated kinase (Erk) pathway, help to integrate influences from the...

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Vydané v:	Integrative biology (Cambridge) Ročník 5; číslo 11; s. 1355
Hlavní autori:	Lau, Ken S, Schrier, Sarah B, Gierut, Jessica, Lyons, Jesse, Lauffenburger, Douglas A, Haigis, Kevin M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.01.2013
Predmet:	Algorithms Alleles Animals Apoptosis Epithelial Cells - metabolism Fuzzy Logic Gene Expression Regulation Genotype Intestines - metabolism Male MAP Kinase Signaling System Mice Mice, Transgenic Models, Biological Mutation Phenotype Phosphatidylinositol 3-Kinases - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Proto-Oncogene Proteins c-akt - metabolism ras Proteins - genetics ras Proteins - metabolism Signal Transduction Tumor Necrosis Factor-alpha - metabolism
ISSN:	1757-9708, 1757-9708
On-line prístup:	Zistit podrobnosti o prístupe
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