The Role of Neutrophils and Neutrophil Extracellular Traps in Vascular Damage in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune syndrome of unknown etiology, characterized by multi-organ inflammation and clinical heterogeneity. SLE affects mostly women and is associated with a high risk of cardiovascular disease. As the therapeutic management of SLE improved, a pattern of e...

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Veröffentlicht in:Journal of clinical medicine Jg. 8; H. 9; S. 1325
Hauptverfasser: O’Neil, Liam J., Kaplan, Mariana J., Carmona-Rivera, Carmelo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI 28.08.2019
Schlagworte:
Review
atherosclerosis
vascular damage
interferon
neutrophils
ISSN:2077-0383, 2077-0383
Online-Zugang:Volltext
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Zusammenfassung:Systemic lupus erythematosus (SLE) is an autoimmune syndrome of unknown etiology, characterized by multi-organ inflammation and clinical heterogeneity. SLE affects mostly women and is associated with a high risk of cardiovascular disease. As the therapeutic management of SLE improved, a pattern of early atherosclerotic disease became one of the hallmarks of late disease morbidity and mortality. Neutrophils emerged as important players in SLE pathogenesis and they are associated with increased risk of developing atherosclerotic disease and vascular damage. Enhanced neutrophil extracellular trap (NET) formation was linked to vasculopathy in both SLE and non-SLE subjects and may promote enhanced coronary plaque formation and lipoprotein dysregulation. Foundational work provided insight into the complex relationship between NETs and immune and tissue resident cells within the diseased artery. In this review, we highlight the mechanistic link between neutrophils, NETs, and atherosclerosis within the context of both SLE and non-SLE subjects. We aim to identify actionable pathways that will drive future research toward translational therapeutics, with the ultimate goal of preventing early morbidity and mortality in SLE.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm8091325