Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

Apical constriction is a cell shape change that promotes tissue remodeling in a variety of homeostatic and developmental contexts, including gastrulation in many organisms and neural tube formation in vertebrates. In recent years, progress has been made towards understanding how the distinct cell bi...

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Bibliographic Details
Published in:Development (Cambridge) Vol. 141; no. 10; p. 1987
Main Authors: Martin, Adam C, Goldstein, Bob
Format: Journal Article
Language:English
Published: England 01.05.2014
Subjects:
Animals
Body Patterning - physiology
Cell Movement - physiology
Cell Polarity - physiology
Cell Shape
Cells, Cultured
Constriction
Cytokinesis - physiology
Humans
Morphogenesis - physiology
Apical
Constriction
Cadherin
Actin
Adhesion
Myosin
ISSN:1477-9129, 1477-9129
Online Access:Get more information
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Summary:Apical constriction is a cell shape change that promotes tissue remodeling in a variety of homeostatic and developmental contexts, including gastrulation in many organisms and neural tube formation in vertebrates. In recent years, progress has been made towards understanding how the distinct cell biological processes that together drive apical constriction are coordinated. These processes include the contraction of actin-myosin networks, which generates force, and the attachment of actin networks to cell-cell junctions, which allows forces to be transmitted between cells. Different cell types regulate contractility and adhesion in unique ways, resulting in apical constriction with varying dynamics and subcellular organizations, as well as a variety of resulting tissue shape changes. Understanding both the common themes and the variations in apical constriction mechanisms promises to provide insight into the mechanics that underlie tissue morphogenesis.
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ISSN:1477-9129
1477-9129
DOI:10.1242/dev.102228