PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

Vascular injury and chronic arterial diseases result in exposure of VSMCs (vascular smooth muscle cells) to increased concentrations of growth factors. The mechanisms by which growth factors trigger VSMC phenotype transitions remain unclear. Because cellular reprogramming initiated by growth factors...

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Vydáno v:	Biochemical journal Ročník 451; číslo 3; s. 375
Hlavní autoři:	Salabei, Joshua K, Cummins, Timothy D, Singh, Mahavir, Jones, Steven P, Bhatnagar, Aruni, Hill, Bradford G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.05.2013
Témata:	Actins - genetics Actins - metabolism Adenine - analogs & derivatives Adenine - pharmacology Aldehydes - pharmacology Animals Aorta - cytology Aorta - drug effects Aorta - metabolism Autophagy - drug effects Autophagy - genetics Biomarkers - metabolism Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Calponins Gene Expression Regulation - drug effects Macrolides - pharmacology Male Microfilament Proteins - genetics Microfilament Proteins - metabolism Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Osteopontin - genetics Osteopontin - metabolism Oxidative Stress Phenotype Platelet-Derived Growth Factor - pharmacology Primary Cell Culture Rats Rats, Sprague-Dawley Signal Transduction - drug effects Vimentin - genetics Vimentin - metabolism
ISSN:	1470-8728, 1470-8728
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