Identification of the remains of the Romanov family by DNA analysis

Nine skeletons found in a shallow grave in Ekaterinburg, Russia, in July 1991, were tentatively identified by Russian forensic authorities as the remains of the last Tsar, Tsarina, three of their five children, the Royal Physician and three servants. We have performed DNA based sex testing and short...

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Vydáno v:Nature genetics Ročník 6; číslo 2; s. 130
Hlavní autoři: Gill, P, Ivanov, P L, Kimpton, C, Piercy, R, Benson, N, Tully, G, Evett, I, Hagelberg, E, Sullivan, K
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.02.1994
Témata:
Base Sequence
Bone and Bones - chemistry
DNA Fingerprinting - history
DNA Fingerprinting - methods
DNA, Mitochondrial - chemistry
DNA, Mitochondrial - genetics
Famous Persons
Female
History, 20th Century
Humans
Male
Molecular Sequence Data
Mutation
Pedigree
Repetitive Sequences, Nucleic Acid
Romanov family
Russia
Sequence Analysis, DNA
Russia
ISSN:1061-4036
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Shrnutí:Nine skeletons found in a shallow grave in Ekaterinburg, Russia, in July 1991, were tentatively identified by Russian forensic authorities as the remains of the last Tsar, Tsarina, three of their five children, the Royal Physician and three servants. We have performed DNA based sex testing and short tandem repeat (STR) analysis and confirm that a family group was present in the grave. Analysis of mitochondrial (mt) DNA reveals an exact sequence match between the putative Tsarina and the three children with a living maternal relative. Amplified mtDNA extracted from the remains of the putative Tsar has been cloned to demonstrate heteroplasmy at a single base within the mtDNA control region. One of these sequences matches two living maternal relatives of the Tsar. We conclude that the DNA evidence supports the hypothesis that the remains are those of the Romanov family.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Biography-1
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ISSN:1061-4036
DOI:10.1038/ng0294-130