A role for human homologous recombination factors in suppressing microhomology-mediated end joining

DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pa...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 44; no. 12; pp. 5743 - 5757
Main Authors:	Ahrabi, Sara, Sarkar, Sovan, Pfister, Sophia X., Pirovano, Giacomo, Higgins, Geoff S., Porter, Andrew C.G., Humphrey, Timothy C.
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 08.07.2016
Subjects:	Base Sequence Biological Assay BRCA1 Protein - antagonists & inhibitors BRCA1 Protein - genetics BRCA1 Protein - metabolism BRCA2 Protein - antagonists & inhibitors BRCA2 Protein - genetics BRCA2 Protein - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor DNA - metabolism DNA Breaks, Double-Stranded DNA End-Joining Repair DNA Polymerase theta DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Endodeoxyribonucleases Epithelial Cells - cytology Epithelial Cells - metabolism Fibroblasts - cytology Fibroblasts - metabolism Genome Integrity, Repair and Humans MRE11 Homologue Protein Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Osteoblasts - cytology Osteoblasts - metabolism Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Recombinational DNA Repair Replication Protein A - antagonists & inhibitors Replication Protein A - genetics Replication Protein A - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Sequence Alignment Sequence Homology, Nucleic Acid
ISSN:	0305-1048, 1362-4962
Online Access:	Get full text
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