Dopamine-deprived striatal GABAergic interneurons burst and generate repetitive gigantic IPSCs in medium spiny neurons

Striatal GABAergic microcircuits modulate cortical responses and movement execution in part by controlling the activity of medium spiny neurons (MSNs). How this is altered by chronic dopamine depletion, such as in Parkinson's disease, is not presently understood. We now report that, in dopamine...

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Veröffentlicht in:	The Journal of neuroscience Jg. 29; H. 24; S. 7776
Hauptverfasser:	Dehorter, Nathalie, Guigoni, Celine, Lopez, Catherine, Hirsch, June, Eusebio, Alexandre, Ben-Ari, Yehezkel, Hammond, Constance
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.06.2009
Schlagworte:	6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Action Potentials - drug effects Action Potentials - physiology Adrenergic Agents - pharmacology Animals Biological Clocks - drug effects Biophysics Corpus Striatum - cytology Dopamine - deficiency Dose-Response Relationship, Drug Electric Stimulation Excitatory Amino Acid Antagonists - pharmacology GABA Agents - pharmacology gamma-Aminobutyric Acid - metabolism In Vitro Techniques Inhibitory Postsynaptic Potentials - drug effects Inhibitory Postsynaptic Potentials - physiology Interneurons - classification Interneurons - drug effects Interneurons - metabolism Lysine - analogs & derivatives Lysine - metabolism Mice Nicotine - pharmacology Nicotinic Agonists - pharmacology Oxidopamine - pharmacology Patch-Clamp Techniques - methods Spectrum Analysis Tyrosine 3-Monooxygenase - metabolism Valine - analogs & derivatives Valine - pharmacology
ISSN:	1529-2401, 1529-2401
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