Flow cytometry evaluation of infection-related biomarkers in febrile subjects in the emergency department

In an Emergency Department (ED), the etiological identification of infected subjects is essential. 13 infection-related biomarkers were assessed using a new flow cytometry procedure. If subjects presented with febrile symptoms at the ED, 13 biomarkers’ levels, including CD64 on neutrophils (nCD64) a...

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Veröffentlicht in:Future microbiology Jg. 15; H. 3; S. 189 - 201
Hauptverfasser: Bourgoin, Pénélope, Lediagon, Guillaume, Arnoux, Isabelle, Bernot, Denis, Morange, Pierre-Emmanuel, Michelet, Pierre, Malergue, Fabrice, Markarian, Thibaut
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Future Medicine Ltd 01.02.2020
Future Medicine
Schlagworte:
Antibiotics
Antigens
bacterial infection
Bacterial infections
Biomarkers
Blood
emergency department
Emergency medical care
Fever
Flow cytometry
Human health and pathology
Infections
Leukocytes (neutrophilic)
Life Sciences
Monocytes
Neutrophils
Pathogens
Statistical analysis
viral infection
Viral infections
United States > US
fever
flow cytometry
viral infection
bacterial infection
emergency department
C-REACTIVE PROTEIN
CD64
EARLY-DIAGNOSIS
PROCALCITONIN
MARKERS
DIFFERENTIATE
ACCURACY
EXAMPLE
BACTERIAL-INFECTION
EXPRESSION
ISSN:1746-0913, 1746-0921, 1746-0921
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Zusammenfassung:In an Emergency Department (ED), the etiological identification of infected subjects is essential. 13 infection-related biomarkers were assessed using a new flow cytometry procedure. If subjects presented with febrile symptoms at the ED, 13 biomarkers’ levels, including CD64 on neutrophils (nCD64) and CD169 on monocytes (mCD169), were tested and compared with clinical records. Among 50 subjects, 78% had bacterial infections and 8% had viral infections. nCD64 showed 82% sensitivity and 91% specificity for identifying subjects with bacterial infections. mCD169, HLA-ABC ratio and HLA-DR on monocytes had high values in subjects with viral infections. Biomarkers showed promising performances to improve the ED's infectious stratification.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1746-0913
1746-0921
1746-0921
DOI:10.2217/fmb-2019-0256