Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes

Using global liquid chromatography-mass spectrometry (LC-MS)-based proteomics analyses, we identified 24 serum proteins that were significantly variant between those with type 1 diabetes (T1D) and healthy controls. Functionally, these proteins represent innate immune responses, the activation cascad...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 210; H. 1; S. 191
Hauptverfasser:	Zhang, Qibin, Fillmore, Thomas L, Schepmoes, Athena A, Clauss, Therese R W, Gritsenko, Marina A, Mueller, Patricia W, Rewers, Marian, Atkinson, Mark A, Smith, Richard D, Metz, Thomas O
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 14.01.2013
Schlagworte:	Amino Acid Sequence Biomarkers - blood Blood Proteins - analysis Case-Control Studies Chromatography, Liquid - methods Complement C1 Inactivator Proteins - analysis Complement C1 Inhibitor Protein Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Humans Hyperglycemia - blood Hyperglycemia - etiology Immunity, Innate Mass Spectrometry - methods Molecular Sequence Data Predictive Value of Tests Proteomics - methods Reference Values Reproducibility of Results ROC Curve Sensitivity and Specificity
ISSN:	1540-9538, 1540-9538
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