Association between metabolic syndrome and risk of incident dementia in UK Biobank

INTRODUCTION The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. METHODS In 176,249 dementia‐free UK Biobank participants aged ≥60 years at baseline, Cox proportional‐hazards models were used to investigate the association between MetS and incident dementia....

Full description

Saved in:
Bibliographic Details
Published in:Alzheimer's & dementia Vol. 20; no. 1; pp. 447 - 458
Main Authors: Qureshi, Danial, Collister, Jennifer, Allen, Naomi E., Kuźma, Elżbieta, Littlejohns, Thomas
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01.01.2024
John Wiley and Sons Inc
Subjects:
Alzheimer's disease
Apolipoproteins
Biobanks
Biological Specimen Banks
Blood pressure
Cholesterol
Codes
cohort studies
Dementia
Dementia - complications
Dementia - epidemiology
Density
Diabetes
Disease
Exercise
follow‐up studies
Genetic susceptibility
Genetics
Glucose
Health risk assessment
Hospitals
Humans
Incidence
Interactive computer systems
Lipids
longitudinal
Longitudinal studies
Males
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Prospective Studies
Questionnaires
Risk
Risk Factors
Sociodemographics
Triglycerides
UK Biobank
England
Scotland
United Kingdom > UK
Wales
metabolic syndrome
follow-up studies
risk factors
UK biobank
cohort studies
dementia
longitudinal
incidence
ISSN:1552-5260, 1552-5279, 1552-5279
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract INTRODUCTION The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. METHODS In 176,249 dementia‐free UK Biobank participants aged ≥60 years at baseline, Cox proportional‐hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high‐density lipoprotein cholesterol. RESULTS Over 15 years of follow‐up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow‐up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein‐E (APOE)‐ε4 non‐carriers. DISCUSSION In this large population‐based prospective cohort, MetS was associated with an increased risk of dementia. Highlights MetS was associated with a 12% increased risk of incident all‐cause dementia. Associations remained similar after restricting the analysis to those with longer follow‐up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.
AbstractList INTRODUCTION The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. METHODS In 176,249 dementia‐free UK Biobank participants aged ≥60 years at baseline, Cox proportional‐hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high‐density lipoprotein cholesterol. RESULTS Over 15 years of follow‐up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow‐up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein‐E (APOE)‐ε4 non‐carriers. DISCUSSION In this large population‐based prospective cohort, MetS was associated with an increased risk of dementia. Highlights MetS was associated with a 12% increased risk of incident all‐cause dementia. Associations remained similar after restricting the analysis to those with longer follow‐up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.
The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. In 176,249 dementia-free UK Biobank participants aged ≥60 years at baseline, Cox proportional-hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high-density lipoprotein cholesterol. Over 15 years of follow-up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow-up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein-E (APOE)-ε4 non-carriers. In this large population-based prospective cohort, MetS was associated with an increased risk of dementia. MetS was associated with a 12% increased risk of incident all-cause dementia. Associations remained similar after restricting the analysis to those with longer follow-up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.
INTRODUCTION The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. METHODS In 176,249 dementia‐free UK Biobank participants aged ≥60 years at baseline, Cox proportional‐hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high‐density lipoprotein cholesterol. RESULTS Over 15 years of follow‐up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow‐up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein‐E (APOE)‐ε4 non‐carriers. DISCUSSION In this large population‐based prospective cohort, MetS was associated with an increased risk of dementia. Highlights MetS was associated with a 12% increased risk of incident all‐cause dementia. Associations remained similar after restricting the analysis to those with longer follow‐up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.
The association between metabolic syndrome (MetS) and incident dementia remains inconclusive.INTRODUCTIONThe association between metabolic syndrome (MetS) and incident dementia remains inconclusive.In 176,249 dementia-free UK Biobank participants aged ≥60 years at baseline, Cox proportional-hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high-density lipoprotein cholesterol.METHODSIn 176,249 dementia-free UK Biobank participants aged ≥60 years at baseline, Cox proportional-hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high-density lipoprotein cholesterol.Over 15 years of follow-up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow-up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein-E (APOE)-ε4 non-carriers.RESULTSOver 15 years of follow-up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow-up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein-E (APOE)-ε4 non-carriers.In this large population-based prospective cohort, MetS was associated with an increased risk of dementia.DISCUSSIONIn this large population-based prospective cohort, MetS was associated with an increased risk of dementia.MetS was associated with a 12% increased risk of incident all-cause dementia. Associations remained similar after restricting the analysis to those with longer follow-up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.HIGHLIGHTSMetS was associated with a 12% increased risk of incident all-cause dementia. Associations remained similar after restricting the analysis to those with longer follow-up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.
Author Kuźma, Elżbieta
Collister, Jennifer
Littlejohns, Thomas
Allen, Naomi E.
Qureshi, Danial
AuthorAffiliation 3 Albertinen Haus Centre for Geriatrics and Gerontology University of Hamburg Hamburg Germany
1 Nuffield Department of Population Health University of Oxford Oxford UK
2 UK Biobank Ltd Stockport UK
AuthorAffiliation_xml – name: 3 Albertinen Haus Centre for Geriatrics and Gerontology University of Hamburg Hamburg Germany
– name: 1 Nuffield Department of Population Health University of Oxford Oxford UK
– name: 2 UK Biobank Ltd Stockport UK
Author_xml – sequence: 1
  givenname: Danial
  orcidid: 0000-0001-5703-2220
  surname: Qureshi
  fullname: Qureshi, Danial
  email: danial.qureshi@dph.ox.ac.uk
  organization: University of Oxford
– sequence: 2
  givenname: Jennifer
  surname: Collister
  fullname: Collister, Jennifer
  organization: University of Oxford
– sequence: 3
  givenname: Naomi E.
  surname: Allen
  fullname: Allen, Naomi E.
  organization: UK Biobank Ltd
– sequence: 4
  givenname: Elżbieta
  surname: Kuźma
  fullname: Kuźma, Elżbieta
  organization: University of Hamburg
– sequence: 5
  givenname: Thomas
  surname: Littlejohns
  fullname: Littlejohns, Thomas
  organization: University of Oxford
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37675869$$D View this record in MEDLINE/PubMed
BookMark eNp1kctuFDEQRS0URB6w4AeQJTawmKTcdnfbKzREvMRISIhs2Fh-VIOTbjuxe4iGr8dkJhFEsCqrfOrqVt1DshdTREKeMjhmAM2JGX8eMy64ekAOWNs2i7bp1d7du4N9cljKOYAAydpHZJ_3Xd_KTh2Qz8tSkgtmDilSi_M1YqQTzsamMThaNtHnNCE10dMcygVNAw3RBY9xph6nWoKpHXr2kb4OyZp48Zg8HMxY8MmuHpGzt2--nL5frD69-3C6XC2cEEItuOwNHxA4a4WRjDsPgjEYFAqF4D2wwQ3KcjU0VnrLrAQD2FrooMPa4Ufk1Vb3cm0n9K5ayWbUlzlMJm90MkH__RPDd_0t_dAMFOuUElXhxU4hp6s1lllPoTgcRxMxrYtuZNcwJbseKvr8Hnqe1jnW_TQHWRnBRV-pZ39auvNye-8KnGwBl1MpGQftwnxz_OowjNWa_p2oronqm0TrxMt7E7ei_2J36tdhxM3_Qb1cfd1O_AIkCrAT
CitedBy_id crossref_primary_10_1186_s12888_024_06375_x
crossref_primary_10_2337_dc24_0537
crossref_primary_10_1177_13872877251326553
crossref_primary_10_1177_13872877251359635
crossref_primary_10_3390_diagnostics14171883
crossref_primary_10_1016_j_envres_2025_121349
crossref_primary_10_1186_s13195_025_01830_7
crossref_primary_10_3233_JAD_240301
crossref_primary_10_1016_j_tjpad_2025_100325
crossref_primary_10_2147_JMDH_S499516
crossref_primary_10_1186_s12889_025_23352_5
crossref_primary_10_1016_j_jad_2025_119733
crossref_primary_10_1212_WNL_0000000000213599
crossref_primary_10_1161_ATVBAHA_125_322702
crossref_primary_10_1007_s12035_025_04947_w
crossref_primary_10_1093_ageing_afaf235
crossref_primary_10_1016_j_annepidem_2025_08_015
crossref_primary_10_1016_j_psyneuen_2025_107444
crossref_primary_10_1016_j_tjpad_2025_100089
crossref_primary_10_1186_s12916_024_03302_5
crossref_primary_10_3389_fnut_2025_1598659
crossref_primary_10_3389_fendo_2023_1330565
crossref_primary_10_1136_thorax_2024_222873
crossref_primary_10_1016_j_lanepe_2025_101428
crossref_primary_10_1186_s12889_025_22865_3
crossref_primary_10_1016_j_diabres_2025_112919
crossref_primary_10_1186_s13098_025_01779_5
crossref_primary_10_1186_s13195_025_01825_4
crossref_primary_10_3390_diagnostics14161831
crossref_primary_10_1007_s10522_025_10300_4
crossref_primary_10_1212_WNL_0000000000214033
crossref_primary_10_1111_dom_15977
crossref_primary_10_1007_s11033_024_09457_x
crossref_primary_10_1212_WNL_0000000000214199
crossref_primary_10_1186_s12979_025_00529_5
crossref_primary_10_1016_j_diabres_2025_112044
crossref_primary_10_3389_fnut_2024_1477537
crossref_primary_10_1186_s13098_024_01398_6
crossref_primary_10_1002_trc2_70104
crossref_primary_10_3389_fendo_2024_1393253
crossref_primary_10_1186_s12963_025_00414_9
crossref_primary_10_1177_13872877251375944
crossref_primary_10_1016_j_tjpad_2025_100311
crossref_primary_10_1210_clinem_dgae295
crossref_primary_10_1186_s13195_024_01581_x
Cites_doi 10.1371/journal.pone.0219668
10.1016/j.kjms.2014.03.005
10.1136/bmj.322.7300.1447
10.1016/j.ssmph.2021.100881
10.1016/j.biopsych.2017.12.003
10.2217/bmm.09.91
10.3233/JAD-190261
10.1016/j.jns.2015.02.004
10.1111/j.1600-0447.2010.01565.x
10.2337/dc10-S011
10.1136/bmjdrc-2020-001436
10.3390/ijms20010063
10.1161/CIRCULATIONAHA.109.192644
10.7326/0003-4819-137-3-200208060-00006
10.2337/dc22-0206
10.1038/s41398-020-0822-x
10.1177/0891988707301867
10.3803/EnM.2020.935
10.1161/JAHA.116.004749
10.1001/jama.285.19.2486
10.2174/1871527317666180724143258
10.1002/dad2.12229
10.1210/JC.2015-1995
10.1159/000105927
10.2165/00129784-200707010-00004
10.1038/s41586-018-0579-z
10.3233/JAD-200674
10.1038/s41467-020-14959-w
10.1016/j.jagp.2019.01.214
10.2337/diabetes.51.4.1256
10.1371/journal.pone.0039461
10.3390/metabo12030249
10.1016/j.numecd.2018.09.004
10.1016/j.lfs.2019.116932
10.1136/jnnp.2009.181743
10.1038/s41588-019-0358-2
10.3233/JAD-180288
10.1111/j.1474-9726.2010.00626.x
10.1001/jamaneurol.2015.4899
10.3233/JAD-2011-111550
10.1016/S0140-6736(20)30367-6
10.1038/s41467-021-22491-8
10.1186/s13742-015-0047-8
10.3233/JAD-160826
10.1016/S0016-5085(20)33182-6
10.1212/WNL.0000000000008779
10.1001/jama.2019.10575
10.1161/HYPERTENSIONAHA.120.14993
10.17305/bjbms.2009.2809
10.1186/s13098-018-0339-0
10.1186/1475-2840-9-34
10.3390/jcm9010122
10.1016/j.arr.2019.100944
10.1111/j.1532-5415.2010.02731.x
10.1038/ncomms11174
10.1016/j.eclinm.2022.101695
10.1249/01.MSS.0000078924.61453.FB
10.2337/dc08-0272
10.1016/j.canep.2016.01.009
10.1038/ng.3916
10.1016/j.diabres.2022.109778
10.1159/000054469
10.2147/CLEP.S37929
10.1007/s10654-019-00499-1
10.3233/JAD-121885
10.1111/jgs.15059
10.1371/journal.pmed.1001779
ContentType Journal Article
Copyright 2023 The Authors. published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2023 The Authors. published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
– notice: 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
– notice: 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID 24P
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QJ
7RV
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9-
K9.
KB0
M0R
M0S
NAPCQ
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
PSYQQ
7X8
5PM
DOI 10.1002/alz.13439
DatabaseName Wiley Online Library Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Applied Social Sciences Index & Abstracts (ASSIA)
Nursing & Allied Health Database
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
Consumer Health Database
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Consumer Health Database
Health & Medical Collection (Alumni Edition)
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic
ProQuest Publicly Available Content
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Psychology
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest One Psychology
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Family Health (Alumni Edition)
Applied Social Sciences Index and Abstracts (ASSIA)
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Family Health
ProQuest One Academic Eastern Edition
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database
MEDLINE

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: 24P
  name: Wiley Online Library Open Access
  url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 7RV
  name: Nursing & Allied Health Database
  url: https://search.proquest.com/nahs
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
DocumentTitleAlternate QURESHI et al
EISSN 1552-5279
EndPage 458
ExternalDocumentID PMC10916994
37675869
10_1002_alz_13439
ALZ13439
Genre article
Journal Article
GeographicLocations England
Scotland
United Kingdom--UK
Wales
GeographicLocations_xml – name: England
– name: Wales
– name: United Kingdom--UK
– name: Scotland
GrantInformation_xml – fundername: Nicolaus and Margrit Langbehn Foundation
– fundername: Canadian Institutes of Health Research
  funderid: DAA – 181627
– fundername: CIHR
  grantid: DAA - 181627
GroupedDBID ---
--K
--M
.~1
0R~
1B1
1OC
1~.
1~5
24P
33P
4.4
457
4G.
53G
5VS
7-5
71M
7RV
7X7
8FI
8FJ
8P~
AACTN
AAEDT
AAHHS
AAIKJ
AAKOC
AALRI
AANLZ
AAOAW
AAXLA
AAXUO
AAYCA
ABBQC
ABCQJ
ABCUV
ABIVO
ABJNI
ABMAC
ABMZM
ABUWG
ABWVN
ACCFJ
ACCMX
ACCZN
ACGFS
ACGOF
ACPOU
ACRPL
ACXQS
ADBBV
ADBTR
ADEZE
ADHUB
ADKYN
ADMUD
ADNMO
ADPDF
ADVLN
ADZMN
ADZOD
AEEZP
AEIGN
AEKER
AENEX
AEQDE
AEUYR
AEVXI
AFKRA
AFTJW
AFWVQ
AGHFR
AGUBO
AGWIK
AGYEJ
AITUG
AIURR
AIWBW
AJBDE
AJOXV
AJRQY
AKRWK
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMFUW
AMRAJ
AMYDB
ANZVX
AZQEC
BENPR
BFHJK
BLXMC
C45
CCPQU
DCZOG
EBS
EJD
EMOBN
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FIRID
FNPLU
FYUFA
G-Q
GBLVA
HMCUK
HVGLF
HX~
HZ~
IHE
J1W
K9-
LATKE
LEEKS
M0R
M41
MO0
MOBAO
N9A
NAPCQ
O-L
O9-
OAUVE
OVD
OVEED
OZT
P-8
P-9
P2P
PC.
PGMZT
PIMPY
PSYQQ
Q38
QTD
RIG
ROL
RPM
RPZ
SDF
SDG
SEL
SES
SSZ
SUPJJ
T5K
TEORI
UKHRP
~G-
9DU
AAMMB
AAYWO
AAYXX
ACVFH
ADCNI
AEFGJ
AEUPX
AFFHD
AFPUW
AGHNM
AGXDD
AIDQK
AIDYY
AIGII
AKBMS
AKYEP
CITATION
EFLBG
PHGZM
PHGZT
PJZUB
PPXIY
~HD
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QJ
7XB
8FK
DWQXO
K9.
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c4449-387a3fe03154a813cd04110f9e49e0dd01fcf9b39f2b8db1b80a0e5b0606eb8d3
IEDL.DBID BENPR
ISICitedReferencesCount 54
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001062944800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1552-5260
1552-5279
IngestDate Tue Nov 04 02:06:17 EST 2025
Sun Nov 09 14:27:06 EST 2025
Sat Nov 08 00:01:36 EST 2025
Mon Jul 21 05:42:20 EDT 2025
Tue Nov 18 22:22:14 EST 2025
Sat Nov 29 07:09:08 EST 2025
Wed Jan 22 16:18:55 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords metabolic syndrome
follow-up studies
risk factors
UK biobank
cohort studies
dementia
longitudinal
incidence
Language English
License Attribution
2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4449-387a3fe03154a813cd04110f9e49e0dd01fcf9b39f2b8db1b80a0e5b0606eb8d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-5703-2220
OpenAccessLink https://www.proquest.com/docview/3089864347?pq-origsite=%requestingapplication%
PMID 37675869
PQID 3089864347
PQPubID 2033427
PageCount 12
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_10916994
proquest_miscellaneous_2862198670
proquest_journals_3089864347
pubmed_primary_37675869
crossref_citationtrail_10_1002_alz_13439
crossref_primary_10_1002_alz_13439
wiley_primary_10_1002_alz_13439_ALZ13439
PublicationCentury 2000
PublicationDate January 2024
PublicationDateYYYYMMDD 2024-01-01
PublicationDate_xml – month: 01
  year: 2024
  text: January 2024
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Chicago
– name: Hoboken
PublicationTitle Alzheimer's & dementia
PublicationTitleAlternate Alzheimers Dement
PublicationYear 2024
Publisher John Wiley & Sons, Inc
John Wiley and Sons Inc
Publisher_xml – name: John Wiley & Sons, Inc
– name: John Wiley and Sons Inc
References 2017; 6
2018; 562
2010; 58
2019; 51
2004; 27
2019; 55
2002; 51
2017; 49
2015; 100
2019; 14
2019; 322
2016; 73
2018; 84
2022; 20
2020; 11
2020; 10
2020; 8
2021; 36
2014; 2
2020; 94
2020; 9
2019; 27
2019; 237
2016; 41
2007; 7
2019; 29
2012; 28
2009; 120
2007; 20
2014; 6
2010; 4
2007; 24
2010; 9
1988
2015; 12
2010; 33
2001; 322
2019; 71
2015; 4
2001; 285
2019; 34
2017; 65
2022; 45
2003; 35
2010; 122
2002; 137
2020; 78
2020; 76
2010; 81
2018; 20
2018; 64
2021; 13
2021; 15
2016; 7
2018; 17
2022; 185
2009; 32
2021; 12
2020; 396
2013; 34
2015; 351
2017; 56
2022; 12
2009; 9
2022; 54
2020; 158
2014; 30
2012; 7
1999; 70
2018; 10
2018; 14
e_1_2_9_75_1
e_1_2_9_31_1
e_1_2_9_52_1
e_1_2_9_50_1
Kaur J (e_1_2_9_37_1) 2014; 2
e_1_2_9_10_1
e_1_2_9_56_1
e_1_2_9_12_1
e_1_2_9_33_1
e_1_2_9_54_1
Singh‐Manoux A (e_1_2_9_60_1) 2018; 14
e_1_2_9_71_1
e_1_2_9_14_1
e_1_2_9_39_1
e_1_2_9_16_1
e_1_2_9_58_1
e_1_2_9_18_1
e_1_2_9_41_1
e_1_2_9_64_1
e_1_2_9_20_1
e_1_2_9_62_1
e_1_2_9_22_1
e_1_2_9_45_1
e_1_2_9_68_1
e_1_2_9_24_1
e_1_2_9_43_1
e_1_2_9_66_1
Zon SK (e_1_2_9_35_1) 2020; 8
e_1_2_9_8_1
e_1_2_9_6_1
e_1_2_9_4_1
e_1_2_9_2_1
Kivimäki M (e_1_2_9_67_1) 2018; 14
e_1_2_9_26_1
e_1_2_9_28_1
e_1_2_9_47_1
Wilkinson T (e_1_2_9_73_1) 2018; 14
e_1_2_9_30_1
e_1_2_9_53_1
e_1_2_9_74_1
e_1_2_9_51_1
e_1_2_9_72_1
e_1_2_9_11_1
e_1_2_9_34_1
e_1_2_9_57_1
e_1_2_9_13_1
e_1_2_9_32_1
e_1_2_9_55_1
AH FEGWM (e_1_2_9_3_1) 2004; 27
e_1_2_9_70_1
e_1_2_9_15_1
e_1_2_9_38_1
e_1_2_9_17_1
e_1_2_9_36_1
e_1_2_9_59_1
e_1_2_9_19_1
e_1_2_9_42_1
e_1_2_9_63_1
e_1_2_9_40_1
e_1_2_9_61_1
e_1_2_9_21_1
e_1_2_9_46_1
e_1_2_9_23_1
e_1_2_9_44_1
e_1_2_9_65_1
e_1_2_9_7_1
Yoo H (e_1_2_9_49_1) 2022; 20
e_1_2_9_5_1
e_1_2_9_9_1
e_1_2_9_25_1
e_1_2_9_27_1
e_1_2_9_48_1
e_1_2_9_69_1
e_1_2_9_29_1
References_xml – volume: 24
  start-page: 185
  year: 2007
  end-page: 192
  article-title: Metabolic syndrome and dementia risk in a multiethnic elderly cohort
  publication-title: Dement Geriatr Cogn Disord
– volume: 70
  start-page: 146
  year: 1999
  end-page: 152
  article-title: Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender
  publication-title: Neuroendocrinology
– volume: 12
  year: 2015
  article-title: UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age
  publication-title: PLoS Med
– volume: 49
  start-page: 1373
  year: 2017
  end-page: 1384
  article-title: Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial‐mediated innate immunity in Alzheimer's disease
  publication-title: Nat Genet
– volume: 71
  start-page: 931
  year: 2019
  end-page: 943
  article-title: Metabolic syndrome and cognitive trajectories in the framingham offspring study
  publication-title: J Alzheimer's Dis
– volume: 34
  start-page: 557
  year: 2019
  end-page: 565
  article-title: Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data
  publication-title: Eur J Epidemiol
– volume: 94
  year: 2020
  article-title: Body mass index, diet, physical inactivity, and the incidence of dementia in 1 million UK women
  publication-title: Neurology
– volume: 84
  start-page: 324
  year: 2018
  end-page: 331
  article-title: Metabolic and cardiovascular complications in obsessive‐compulsive disorder: a total population, sibling comparison study with long‐term follow‐up
  publication-title: Biol Psychiatry
– volume: 10
  start-page: 145
  year: 2020
  article-title: Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta‐analysis
  publication-title: Transl Psychiatry
– volume: 73
  start-page: 456
  year: 2016
  end-page: 463
  article-title: Metabolic syndrome and the risk of mild cognitive impairment and progression to dementia: follow‐up of the Singapore longitudinal ageing study cohort
  publication-title: JAMA Neurol
– volume: 12
  start-page: 1
  year: 2021
  end-page: 16
  article-title: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
  publication-title: Nat Commun
– volume: 81
  start-page: 433
  year: 2010
  end-page: 440
  article-title: Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing
  publication-title: J Neurol Neurosurg Psychiatry
– volume: 20
  start-page: 138
  year: 2007
  end-page: 144
  article-title: Characterization of the lipid profile in dementia and depression in the elderly
  publication-title: J Geriatr Psychiatry Neurol
– volume: 100
  start-page: 3050
  year: 2015
  end-page: 3059
  article-title: Longitudinal associations between metabolic syndrome components and telomere shortening
  publication-title: J Clin Endocrinol Metab
– volume: 562
  start-page: 203
  year: 2018
  end-page: 209
  article-title: The UK Biobank resource with deep phenotyping and genomic data
  publication-title: Nature
– volume: 58
  start-page: 487
  year: 2010
  end-page: 492
  article-title: Metabolic syndrome and risk of dementia in older adults
  publication-title: J Am Geriatr Soc
– volume: 8
  year: 2020
  article-title: Occupational distribution of metabolic syndrome prevalence and incidence differs by sex and is not explained by age and health behavior: results from 75 000 Dutch workers from 40 occupational groups
  publication-title: BMJ Open Diabetes Res Care
– volume: 9
  start-page: 215
  year: 2009
  article-title: Decreased serum lipids in patients with probable Alzheimer's disease
  publication-title: Bosn J Basic Med Sci
– volume: 15
  year: 2021
  article-title: Metabolic syndrome incidence in an aging workforce: occupational differences and the role of health behaviors
  publication-title: SSM‐Popul health
– volume: 28
  start-page: 931
  year: 2012
  end-page: 939
  article-title: Metabolic syndrome, diabetes, poor cognition, and dementia in the Caerphilly prospective study
  publication-title: J Alzheimer's Dis
– volume: 9
  start-page: 122
  year: 2020
  article-title: Changes in metabolic syndrome status and risk of dementia
  publication-title: J Clin Med
– volume: 7
  year: 2016
  article-title: Variants near CHRNA3/5 and APOE have age‐and sex‐related effects on human lifespan
  publication-title: Nat Commun
– volume: 36
  start-page: 424
  year: 2021
  end-page: 435
  article-title: Cumulative exposure to metabolic syndrome components and the risk of dementia: a nationwide population‐based study
  publication-title: Endocrinol Metab
– volume: 27
  start-page: 625
  year: 2019
  end-page: 637
  article-title: Metabolic syndrome, mild cognitive impairment, and dementia: a meta‐analysis of longitudinal studies
  publication-title: Am J Geriatr Psychiatry
– volume: 30
  start-page: 343
  year: 2014
  end-page: 349
  article-title: Effects of metabolic syndrome, apolipoprotein E, and CYP46 on cognition among Taiwanese Chinese
  publication-title: Kaohsiung J Med Sci
– volume: 32
  start-page: 169
  year: 2009
  end-page: 174
  article-title: Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three‐City Study
  publication-title: Diabetes Care
– volume: 20
  start-page: 63
  year: 2018
  article-title: The synergistic effects of APOE genotype and obesity on Alzheimer's disease risk
  publication-title: Int J Mol Sci
– volume: 6
  start-page: 37
  year: 2014
  article-title: Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences
  publication-title: Clin Epidemiol
– volume: 7
  start-page: 39
  year: 2007
  end-page: 58
  article-title: Management of dyslipidemia in the metabolic syndrome: recommendations of the Spanish HDL‐Forum
  publication-title: Am J Cardiovasc Drugs
– volume: 14
  start-page: 601
  year: 2018
  end-page: 609
  article-title: Body mass index and risk of dementia: analysis of individual‐level data from 1.3 million individuals
  publication-title: Alzheimer's Dis
– volume: 396
  start-page: 413
  year: 2020
  end-page: 446
  article-title: Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
  publication-title: Lancet North Am Ed
– volume: 55
  year: 2019
  article-title: Diabetes mellitus and risks of cognitive impairment and dementia: a systematic review and meta‐analysis of 144 prospective studies
  publication-title: Ageing Res Rev
– volume: 7
  year: 2012
  article-title: A network‐based approach to visualize prevalence and progression of metabolic syndrome components
  publication-title: PLoS One
– volume: 10
  start-page: 1
  year: 2018
  end-page: 8
  article-title: Establishing post mortem criteria for the metabolic syndrome: an autopsy based cross‐sectional study
  publication-title: Diabetol Metab Syndr
– volume: 122
  start-page: 30
  year: 2010
  end-page: 39
  article-title: Metabolic syndrome abnormalities are associated with severity of anxiety and depression and with tricyclic antidepressant use
  publication-title: Acta Psychiatr Scand
– volume: 185
  year: 2022
  article-title: Longitudinal association of Apolipoprotein E polymorphism with lipid profile, type 2 diabetes and metabolic syndrome: results from a 15 year follow‐up study
  publication-title: Diabetes Res Clin Pract
– volume: 13
  year: 2021
  article-title: Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score
  publication-title: Alzheimer's Dement: Diagn Assess Dis Monit
– volume: 76
  start-page: 217
  year: 2020
  end-page: 225
  article-title: Blood pressure and risks of cognitive impairment and dementia: a systematic review and meta‐analysis of 209 prospective studies
  publication-title: Hypertension
– volume: 2
  start-page: 140
  year: 2014
  end-page: 152
  article-title: Assessment and screening of the risk factors in metabolic syndrome
  publication-title: Medi Sci
– volume: 14
  start-page: 178
  year: 2018
  end-page: 186
  article-title: Obesity trajectories and risk of dementia: 28 years of follow‐up in the Whitehall II Study
  publication-title: Alzheimer's Dis
– volume: 237
  year: 2019
  article-title: Pathogenetic pathways of cognitive dysfunction and dementia in metabolic syndrome
  publication-title: Life Sci
– volume: 35
  start-page: 1381
  year: 2003
  end-page: 1395
  article-title: International physical activity questionnaire: 12‐country reliability and validity
  publication-title: Med Sci Sports Exerc
– volume: 20
  start-page: 29
  year: 2022
  end-page: 35
  article-title: Effect of metabolic syndrome on the incidence of dementia based on national insurance data in Korea
  publication-title: Metab Syndr Relat Disord
– volume: 14
  year: 2019
  article-title: The impact of APOE genotype on survival: results of 38,537 participants from six population‐based cohorts (E2‐CHARGE)
  publication-title: PLoS One
– volume: 158
  start-page: S
  year: 2020
  end-page: 1003
  article-title: Tu1007 worldwide incidence and prevalence of metabolic syndrome: a systematic review and meta‐analysis of 14.6 million individuals
  publication-title: Gastroenterology
– volume: 65
  start-page: 2425
  year: 2017
  end-page: 2430
  article-title: Racial differences in the association between apolipoprotein E risk alleles and overall and total cardiovascular mortality over 18 years
  publication-title: J Am Geriatr Soc
– volume: 9
  start-page: 1
  year: 2010
  end-page: 12
  article-title: Age‐and sex‐specific prevalence and ten‐year risk for cardiovascular disease of all 16 risk factor combinations of the metabolic syndrome‐A cross‐sectional study
  publication-title: Cardiovasc Diabetol
– volume: 4
  start-page: 3
  year: 2010
  end-page: 14
  article-title: Alzheimer's prevention initiative: a proposal to evaluate presymptomatic treatments as quickly as possible
  publication-title: Biomark Med
– volume: 29
  start-page: 15
  year: 2019
  end-page: 22
  article-title: Ethnic differences in metabolic cardiovascular risk among normal weight individuals: implications for cardiovascular risk screening. The HELIUS study
  publication-title: Nutr Metab Cardiovasc Dis
– volume: 78
  start-page: 3
  year: 2020
  end-page: 12
  article-title: Future directions for dementia risk reduction and prevention research: an international research network on dementia prevention consensus
  publication-title: J Alzheimer's Dis
– volume: 33
  start-page: S11
  year: 2010
  end-page: S61
  article-title: Standards of medical care in diabetes—2010
  publication-title: Diabetes Care
– volume: 56
  start-page: 215
  year: 2017
  end-page: 228
  article-title: Updating the evidence on the association between serum cholesterol and risk of late‐life dementia: review and meta‐analysis
  publication-title: J Alzheimer's Dis
– volume: 14
  start-page: 1038
  year: 2018
  end-page: 1051
  article-title: Identifying dementia cases with routinely collected health data: a systematic review
  publication-title: Alzheimer's Dis
– volume: 137
  start-page: 149
  year: 2002
  end-page: 155
  article-title: Apolipoprotein E ε4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late‐life Alzheimer disease
  publication-title: Ann Intern Med
– volume: 51
  start-page: 1256
  year: 2002
  end-page: 1262
  article-title: Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu‐Asia Aging Study
  publication-title: Diabetes
– volume: 12
  start-page: 249
  year: 2022
  article-title: Matching drug metabolites from non‐targeted metabolomics to self‐reported medication in the Qatar biobank study
  publication-title: Metabolites
– volume: 51
  start-page: 414
  year: 2019
  end-page: 430
  article-title: Genetic meta‐analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
  publication-title: Nat Genet
– volume: 120
  start-page: 1640
  year: 2009
  end-page: 1645
  article-title: Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity
  publication-title: Circulation
– volume: 41
  start-page: 42
  year: 2016
  end-page: 49
  article-title: Health conditions associated with metabolic syndrome after cancer at a young age: a nationwide register‐based study
  publication-title: Cancer Epidemiol
– volume: 27
  start-page: 9
  year: 2004
  article-title: Increasing prevalence of the metabolic syndrome among US adults
  publication-title: Diabetes Care
– volume: 351
  start-page: 18
  year: 2015
  end-page: 23
  article-title: The metabolic syndrome in a memory clinic population: relation with clinical profile and prognosis
  publication-title: J Neurol Sci
– volume: 34
  start-page: 649
  year: 2013
  end-page: 657
  article-title: Metabolic syndrome and amnestic mild cognitive impairment: singapore Longitudinal Ageing Study‐2 findings
  publication-title: J Alzheimer's Dis
– volume: 9
  start-page: 1004
  year: 2010
  end-page: 1009
  article-title: Increased effect of the ApoE gene on survival at advanced age in healthy and long‐lived Danes: two nationwide cohort studies
  publication-title: Aging Cell
– volume: 322
  start-page: 1447
  year: 2001
  end-page: 1451
  article-title: Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
  publication-title: BMJ
– volume: 54
  year: 2022
  article-title: Serum lipid traits and the risk of dementia: a cohort study of 254,575 women and 214,891 men in the UK Biobank
  publication-title: Eclinicalmedicine
– year: 1988
– volume: 6
  year: 2017
  article-title: Impact of worsened metabolic syndrome on the risk of dementia: a nationwide cohort study
  publication-title: J Am Heart Assoc
– volume: 322
  start-page: 535
  year: 2019
  end-page: 545
  article-title: Association of midlife to late‐life blood pressure patterns with incident dementia
  publication-title: JAMA
– volume: 45
  start-page: 2127
  year: 2022
  end-page: 2135
  article-title: Association of metabolic syndrome with incident dementia: role of number and age at measurement of components in a 28‐year follow‐up of the Whitehall II cohort study
  publication-title: Diabetes Care
– volume: 11
  start-page: 1
  year: 2020
  end-page: 12
  article-title: Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome
  publication-title: Nat Commun
– volume: 4
  year: 2015
  article-title: Second‐generation PLINK: rising to the challenge of larger and richer datasets
  publication-title: Gigascience
– volume: 64
  start-page: 657
  year: 2018
  end-page: 668
  article-title: Does treating vascular risk factors prevent dementia and Alzheimer's disease? A systematic review and meta‐analysis
  publication-title: J Alzheimer's Dis
– volume: 285
  start-page: 2486
  year: 2001
  end-page: 2497
  article-title: Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
  publication-title: JAMA
– volume: 17
  start-page: 595
  year: 2018
  end-page: 603
  article-title: Metabolic syndrome and its effect on the brain: possible mechanism
  publication-title: CNS Neurol Disord Drug Targets
– ident: e_1_2_9_56_1
  doi: 10.1371/journal.pone.0219668
– ident: e_1_2_9_19_1
  doi: 10.1016/j.kjms.2014.03.005
– ident: e_1_2_9_69_1
  doi: 10.1136/bmj.322.7300.1447
– volume: 14
  start-page: 601
  year: 2018
  ident: e_1_2_9_67_1
  article-title: Body mass index and risk of dementia: analysis of individual‐level data from 1.3 million individuals
  publication-title: Alzheimer's Dis
– ident: e_1_2_9_32_1
  doi: 10.1016/j.ssmph.2021.100881
– ident: e_1_2_9_27_1
  doi: 10.1016/j.biopsych.2017.12.003
– ident: e_1_2_9_74_1
  doi: 10.2217/bmm.09.91
– ident: e_1_2_9_51_1
  doi: 10.3233/JAD-190261
– ident: e_1_2_9_9_1
  doi: 10.1016/j.jns.2015.02.004
– ident: e_1_2_9_34_1
  doi: 10.1111/j.1600-0447.2010.01565.x
– ident: e_1_2_9_23_1
  doi: 10.2337/dc10-S011
– volume: 8
  year: 2020
  ident: e_1_2_9_35_1
  article-title: Occupational distribution of metabolic syndrome prevalence and incidence differs by sex and is not explained by age and health behavior: results from 75 000 Dutch workers from 40 occupational groups
  publication-title: BMJ Open Diabetes Res Care
  doi: 10.1136/bmjdrc-2020-001436
– ident: e_1_2_9_17_1
  doi: 10.3390/ijms20010063
– ident: e_1_2_9_2_1
  doi: 10.1161/CIRCULATIONAHA.109.192644
– ident: e_1_2_9_18_1
  doi: 10.7326/0003-4819-137-3-200208060-00006
– ident: e_1_2_9_6_1
  doi: 10.2337/dc22-0206
– ident: e_1_2_9_59_1
  doi: 10.1038/s41398-020-0822-x
– ident: e_1_2_9_38_1
– ident: e_1_2_9_63_1
  doi: 10.1177/0891988707301867
– ident: e_1_2_9_65_1
  doi: 10.3803/EnM.2020.935
– ident: e_1_2_9_10_1
  doi: 10.1161/JAHA.116.004749
– ident: e_1_2_9_48_1
  doi: 10.1001/jama.285.19.2486
– ident: e_1_2_9_70_1
  doi: 10.2174/1871527317666180724143258
– ident: e_1_2_9_41_1
  doi: 10.1002/dad2.12229
– ident: e_1_2_9_31_1
  doi: 10.1210/JC.2015-1995
– ident: e_1_2_9_12_1
  doi: 10.1159/000105927
– ident: e_1_2_9_24_1
  doi: 10.2165/00129784-200707010-00004
– ident: e_1_2_9_40_1
  doi: 10.1038/s41586-018-0579-z
– ident: e_1_2_9_72_1
  doi: 10.3233/JAD-200674
– ident: e_1_2_9_46_1
  doi: 10.1038/s41467-020-14959-w
– volume: 27
  start-page: 9
  year: 2004
  ident: e_1_2_9_3_1
  article-title: Increasing prevalence of the metabolic syndrome among US adults
  publication-title: Diabetes Care
– ident: e_1_2_9_5_1
  doi: 10.1016/j.jagp.2019.01.214
– ident: e_1_2_9_20_1
  doi: 10.2337/diabetes.51.4.1256
– ident: e_1_2_9_26_1
  doi: 10.1371/journal.pone.0039461
– ident: e_1_2_9_33_1
  doi: 10.3390/metabo12030249
– ident: e_1_2_9_29_1
  doi: 10.1016/j.numecd.2018.09.004
– volume: 20
  start-page: 29
  year: 2022
  ident: e_1_2_9_49_1
  article-title: Effect of metabolic syndrome on the incidence of dementia based on national insurance data in Korea
  publication-title: Metab Syndr Relat Disord
– ident: e_1_2_9_71_1
  doi: 10.1016/j.lfs.2019.116932
– ident: e_1_2_9_15_1
  doi: 10.1136/jnnp.2009.181743
– ident: e_1_2_9_43_1
  doi: 10.1038/s41588-019-0358-2
– ident: e_1_2_9_75_1
  doi: 10.3233/JAD-180288
– ident: e_1_2_9_53_1
  doi: 10.1111/j.1474-9726.2010.00626.x
– ident: e_1_2_9_13_1
  doi: 10.1001/jamaneurol.2015.4899
– ident: e_1_2_9_8_1
  doi: 10.3233/JAD-2011-111550
– volume: 14
  start-page: 178
  year: 2018
  ident: e_1_2_9_60_1
  article-title: Obesity trajectories and risk of dementia: 28 years of follow‐up in the Whitehall II Study
  publication-title: Alzheimer's Dis
– ident: e_1_2_9_21_1
  doi: 10.1016/S0140-6736(20)30367-6
– ident: e_1_2_9_42_1
  doi: 10.1038/s41467-021-22491-8
– ident: e_1_2_9_45_1
  doi: 10.1186/s13742-015-0047-8
– ident: e_1_2_9_61_1
  doi: 10.3233/JAD-160826
– ident: e_1_2_9_4_1
  doi: 10.1016/S0016-5085(20)33182-6
– ident: e_1_2_9_50_1
  doi: 10.1212/WNL.0000000000008779
– ident: e_1_2_9_68_1
  doi: 10.1001/jama.2019.10575
– ident: e_1_2_9_57_1
  doi: 10.1161/HYPERTENSIONAHA.120.14993
– ident: e_1_2_9_64_1
  doi: 10.17305/bjbms.2009.2809
– ident: e_1_2_9_25_1
  doi: 10.1186/s13098-018-0339-0
– ident: e_1_2_9_66_1
  doi: 10.1186/1475-2840-9-34
– ident: e_1_2_9_7_1
  doi: 10.3390/jcm9010122
– ident: e_1_2_9_58_1
  doi: 10.1016/j.arr.2019.100944
– ident: e_1_2_9_11_1
  doi: 10.1111/j.1532-5415.2010.02731.x
– ident: e_1_2_9_54_1
  doi: 10.1038/ncomms11174
– ident: e_1_2_9_62_1
  doi: 10.1016/j.eclinm.2022.101695
– ident: e_1_2_9_39_1
  doi: 10.1249/01.MSS.0000078924.61453.FB
– volume: 2
  start-page: 140
  year: 2014
  ident: e_1_2_9_37_1
  article-title: Assessment and screening of the risk factors in metabolic syndrome
  publication-title: Medi Sci
– ident: e_1_2_9_14_1
  doi: 10.2337/dc08-0272
– ident: e_1_2_9_28_1
  doi: 10.1016/j.canep.2016.01.009
– ident: e_1_2_9_44_1
  doi: 10.1038/ng.3916
– ident: e_1_2_9_30_1
  doi: 10.1016/j.diabres.2022.109778
– ident: e_1_2_9_52_1
  doi: 10.1159/000054469
– ident: e_1_2_9_47_1
  doi: 10.2147/CLEP.S37929
– ident: e_1_2_9_36_1
  doi: 10.1007/s10654-019-00499-1
– ident: e_1_2_9_16_1
  doi: 10.3233/JAD-121885
– ident: e_1_2_9_55_1
  doi: 10.1111/jgs.15059
– ident: e_1_2_9_22_1
  doi: 10.1371/journal.pmed.1001779
– volume: 14
  start-page: 1038
  year: 2018
  ident: e_1_2_9_73_1
  article-title: Identifying dementia cases with routinely collected health data: a systematic review
  publication-title: Alzheimer's Dis
SSID ssj0040815
Score 2.5726864
Snippet INTRODUCTION The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. METHODS In 176,249 dementia‐free UK Biobank...
The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. In 176,249 dementia-free UK Biobank participants aged ≥60 years...
INTRODUCTION The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. METHODS In 176,249 dementia‐free UK Biobank...
The association between metabolic syndrome (MetS) and incident dementia remains inconclusive.INTRODUCTIONThe association between metabolic syndrome (MetS) and...
SourceID pubmedcentral
proquest
pubmed
crossref
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 447
SubjectTerms Alzheimer's disease
Apolipoproteins
Biobanks
Biological Specimen Banks
Blood pressure
Cholesterol
Codes
cohort studies
Dementia
Dementia - complications
Dementia - epidemiology
Density
Diabetes
Disease
Exercise
follow‐up studies
Genetic susceptibility
Genetics
Glucose
Health risk assessment
Hospitals
Humans
Incidence
Interactive computer systems
Lipids
longitudinal
Longitudinal studies
Males
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Prospective Studies
Questionnaires
Risk
Risk Factors
Sociodemographics
Triglycerides
UK Biobank
SummonAdditionalLinks – databaseName: Wiley Online Library Open Access
  dbid: 24P
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NT9swFH-CsgMXBmIfZQUZtMMuAcdxG1s7dYgKCYQQAqniEtmxrUXrUkQLh_31e3Y-aAVISNwi58Vx_D79Yv8ewHfOlTRWmiilNo24yFWkUumNoZCG99GHOBWKTaQXF2I8lpcr8LM5C1PhQ7QJN68ZwV57BVd6dvQEGqom_w7jBP3pKqzFcSJ83QbGLxszzNHX9QNYat-vtga0gRWi7Kh9dNkZPYswn2-UXAxggwcafXzX2Ddhow48ybCSlC1YseU2XC1wh9RbtshfO0fJmBQ5aeAMiCoN8ZvQydQRn5z3p3uJCZnFQmELuTkjvwo0DeWfT3AzOrk-Po3qKgtRzjmXHlxXJc76ag9ciTjJDeUYEzhpubTUGBq73EmdSMe0MDrWgipq-5ri0sdiS_IZOuW0tF-BMO2olkYwrTVPBk75svTYL2MSA3nDu_Cjme4sryHIfSWMSVaBJ7MMJyYLE9OFg5b0rsLdeImo1_Asq1VvliUoZQLjLJ52Yb-9jUrj_4So0k4fZhnDdVyMVCntwpeKxe1bAryNGGDnYon5LYEH5F6-Uxa_AzC3B1kdSOm_M3D_9ZFnw_PbcLHzdtJvsM4woqryPz3ozO8f7C58yB_nxex-Lwj_f_A-B70
  priority: 102
  providerName: Wiley-Blackwell
Title Association between metabolic syndrome and risk of incident dementia in UK Biobank
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falz.13439
https://www.ncbi.nlm.nih.gov/pubmed/37675869
https://www.proquest.com/docview/3089864347
https://www.proquest.com/docview/2862198670
https://pubmed.ncbi.nlm.nih.gov/PMC10916994
Volume 20
WOSCitedRecordID wos001062944800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Consumer Health Database
  customDbUrl:
  eissn: 1552-5279
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0040815
  issn: 1552-5260
  databaseCode: M0R
  dateStart: 20240101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/familyhealth
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1552-5279
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0040815
  issn: 1552-5260
  databaseCode: 7X7
  dateStart: 20240101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Nursing & Allied Health Database
  customDbUrl:
  eissn: 1552-5279
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0040815
  issn: 1552-5260
  databaseCode: 7RV
  dateStart: 20240101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/nahs
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1552-5279
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0040815
  issn: 1552-5260
  databaseCode: BENPR
  dateStart: 20240101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1552-5279
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0040815
  issn: 1552-5260
  databaseCode: PIMPY
  dateStart: 20240101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVWIB
  databaseName: Wiley Online Library Open Access
  customDbUrl:
  eissn: 1552-5279
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0040815
  issn: 1552-5260
  databaseCode: 24P
  dateStart: 20240101
  isFulltext: true
  titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  providerName: Wiley-Blackwell
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED-xlgde-BBfhTEZxAMvYY7jNvYT2tAmEKyKKoYKL5Ed2yKipGPteOCv585JSqcBL7xYie04sc--O58vvwN4LqXRzmuX5NzniVSVSUyuiRkq7eQYZUgwMdhEPp2q-VwXncFt1blV9jwxMmq3rMhGvp_hwwrFp8xfnX1PKGoUna52ITR2YEhIZXIAw8OjaTHrebFEgTeOiKlj2nJNeI8txMW-Wfx8mWaSooRvS6QrauZVb8ltLTaKoeNb_9uB23CzU0DZQTtj7sA139yF2RaVWOe6xb75Nc6QRV2xHtaAmcYxckZny8DISE9_-TIXLYy1wRx2-o4d1sgimq_34PT46MPrN0kXbSGppJSaQHZNFjxFfZBGpVnluETdIGgvtefO8TRUQdtMB2GVs6lV3HA_thy3QB5zsvswaJaNfwhM2MCtdkpYa2U2CYbC02O7QmhU6J0cwYt-xMuqgyKniBiLsgVRFiUSp4zEGcGzTdWzFn_jT5V2-yEvuyW4Kn-P9wiebopx8dCJiGn88mJVCtzPpVgr5yN40FJ585YIc6Mm2Li6RP9NBQLmvlzS1F8iQDeBrU60pn7GqfL3Ly8P3n-OF4_-3YXHcEOgNtXafnZhsD6_8E_gevVjXa_O92BHyALTfPaR0nkeU7XXrQa8O-GYDou3J8WnX6YpEig
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VggQXHuK1UMAgkLiEOo53Yx8QKo-q1S4rVLWo6iXYsS0ilmzpbkHwo_iNzDjJslWBWw_cImfixPHnmbE9_gbgsZRGO69dknOfJ1KVJjG5JmWotJN9tCHBxGQT-Xis9vf1uxX42Z2FobDKTidGRe2mJa2Rr2f4sELzKfMXh18SyhpFu6tdCo0GFkP__RtO2WbPt19j_z4RYvPN7qutpM0qkJRSSk1ksiYLnrIbSKPSrHRcog0M2kvtuXM8DWXQNtNBWOVsahU33PctR1ffY0mG9Z6D86jHUwohy3fed5pfonntR37WPk3wBrxjMuJi3Ux-PEszSTnJl-3fKaf2dGzmss8cjd7mlf_td12Fy617zTaa8XANVnx9HXaWMMjawDT22c8R_5OqZB1pAzO1YxRqz6aB0RYEnWFmLq6fVgZL2N6QvaxQAdafbsDemTTjJqzW09rfBiZs4FY7Jay1MhsEkxG_L_pBQuN0xckePO16uChbonXK9zEpGopoUSAYigiGHjxaiB427CJ_ElrrurhoFcys-N2_PXi4uI2qgfZ7TO2nx7NC4Gw1Ramc9-BWg6rFWyKJjxpg5eoE3hYCRDt-8k5dfYz040QlO9Ca2hmh-fcvLzZGB_Hizr-b8AAubu2-HRWj7fHwLlwS6Dc2q1xrsDo_Ovb34EL5dV7Nju7H8cbgw1kj9heG4mdw
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6VFqFeKIg-FgoYxKGXtI7jbGyJS0u7ArVarRCVKi6WHdsiYslW3S2H_vqOnQddlUpI3CJn4jiepyf2NwAfONfSOmmTgroi4aLUiS5kMIZCWp6jD_E6FpsoxmNxcSEnK_CxOwvT4EP0CbegGdFeBwV3l9Yf_EEN1dOb_TRDh_oI1nhepEGmGZ90dpijs8sjWmoelltD2uEKUXbQP7rsje6FmPd3St6NYKMLGm383-CfwdM29CSHjaw8hxVXv4Cvd_hD2k1b5JdboGxMq5J0gAZE15aEbehk5klIz4fzvcTG3GKlsYWcn5KjCo1D_XMTzkcn3z59Tto6C0nJOZcBXldn3oV6D1yLNCst5RgVeOm4dNRamvrSS5NJz4ywJjWCaupyQ3Hx47Al24LVela7HSDMeGqkFcwYw7Oh16EwPfbLmMRQ3vIB7HXzrcoWhDzUwpiqBj6ZKZwYFSdmAO970ssGeeNvRLsd01SrfHOVoZwJjLR4MYB3_W1Um_AvRNdudj1XDFdyKVIVdADbDY_7t0SAGzHEzsUS93uCAMm9fKeufkRo7gCzOpQyfGdk_8MjV4dn3-PFy38nfQtPJscjdfZlfPoK1hmGV00yaBdWF1fX7jU8Ln8vqvnVm6gItzr7Cyw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+between+metabolic+syndrome+and+risk+of+incident+dementia+in+UK+Biobank&rft.jtitle=Alzheimer%27s+%26+dementia&rft.au=Qureshi%2C+Danial&rft.au=Collister%2C+Jennifer&rft.au=Allen%2C+Naomi+E&rft.au=Ku%C5%BAma%2C+El%C5%BCbieta&rft.date=2024-01-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=1552-5260&rft.eissn=1552-5279&rft.volume=20&rft.issue=1&rft.spage=447&rft.epage=458&rft_id=info:doi/10.1002%2Falz.13439
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1552-5260&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1552-5260&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1552-5260&client=summon