Biasing human epidermal growth factor receptor 4 (HER4) tyrosine kinase signaling with antibodies: Induction of cell death by antibody‐dependent HER4 intracellular domain trafficking

Human epidermal growth factor receptor 4 (HER4) isoforms have oncogenic or tumor suppressor functions depending on their susceptibility to proteolytic cleavage and HER4 intracellular domain (4ICD) translocation. Here, we report that the neuregulin 1 (NRG1) tumor suppressor mechanism through the HER4...

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Bibliographic Details
Published in:	Cancer science Vol. 111; no. 7; pp. 2508 - 2525
Main Authors:	Lanotte, Romain, Garambois, Véronique, Gaborit, Nadège, Larbouret, Christel, Musnier, Astrid, Martineau, Pierre, Pèlegrin, André, Chardès, Thierry
Format:	Journal Article
Language:	English
Published:	Tokyo John Wiley & Sons, Inc 01.07.2020 John Wiley and Sons Inc
Subjects:	4ICD antibody Apoptosis Breast cancer cancer Cell cycle Cell death Cell growth Cervix Depolarization DNA fragmentation Epidermal growth factor Epitopes Experiments Flow cytometry HER4 Intracellular Intracellular signalling Isoforms Kinases Ligands Medical prognosis Membrane potential Mitochondria Neuregulin Neuregulin 1 Original Ovarian cancer Poly(ADP-ribose) polymerase Protein-tyrosine kinase Proteolysis Reactive oxygen species Ribose Tumor suppressor genes Xenografts
ISSN:	1347-9032, 1349-7006, 1349-7006
Online Access:	Get full text
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