Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality

We hypothesized that subjects with a normal body mass index (BMI), but high body fat (BF) content [normal weight obesity (NWO)], have a higher prevalence of cardiometabolic dysregulation and are at higher risk for cardiovascular (CV) mortality. We analysed 6171 subjects >20 years of age from the...

Full description

Saved in:

Bibliographic Details
Published in:	European heart journal Vol. 31; no. 6; p. 737
Main Authors:	Romero-Corral, Abel, Somers, Virend K, Sierra-Johnson, Justo, Korenfeld, Yoel, Boarin, Simona, Korinek, Josef, Jensen, Michael D, Parati, Gianfranco, Lopez-Jimenez, Francisco
Format:	Journal Article
Language:	English
Published:	England 01.03.2010
Subjects:	Adipose Tissue - metabolism Adult Aged Body Composition - physiology Body Mass Index Cardiovascular Diseases - metabolism Cardiovascular Diseases - mortality Female Humans Male Metabolic Syndrome - mortality Middle Aged Obesity - metabolism Obesity - mortality Risk Factors United States - epidemiology Young Adult
ISSN:	1522-9645, 1522-9645
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	We hypothesized that subjects with a normal body mass index (BMI), but high body fat (BF) content [normal weight obesity (NWO)], have a higher prevalence of cardiometabolic dysregulation and are at higher risk for cardiovascular (CV) mortality. We analysed 6171 subjects >20 years of age from the Third National Health and Nutrition Examination Survey (NHANES III) and the NHANES III mortality study, whose BMI was within the normal range (18.5-24.9 kg/m(2)), and who underwent a complete evaluation that included body composition assessment, blood measurements, and assessment of CV risk factors. Survival information was available for >99% of the subjects after a median follow-up of 8.8 years. We divided our sample using sex-specific tertiles of BF%. The highest tertile of BF (>23.1% in men and >33.3% in women) was labelled as NWO. When compared with the low BF group, the prevalence of metabolic syndrome in subjects with NWO was four-fold higher (16.6 vs. 4.8%, P < 0.0001). Subjects with NWO also had higher prevalence of dyslipidaemia, hypertension (men), and CV disease (women). After adjustment, women with NWO showed a significant 2.2-fold increased risk for CV mortality (HR = 2.2; 95% CI, 1.03-4.67) in comparison to the low BF group. Normal weight obesity, defined as the combination of normal BMI and high BF content, is associated with a high prevalence of cardiometabolic dysregulation, metabolic syndrome, and CV risk factors. In women, NWO is independently associated with increased risk for CV mortality.
AbstractList	We hypothesized that subjects with a normal body mass index (BMI), but high body fat (BF) content [normal weight obesity (NWO)], have a higher prevalence of cardiometabolic dysregulation and are at higher risk for cardiovascular (CV) mortality.AIMSWe hypothesized that subjects with a normal body mass index (BMI), but high body fat (BF) content [normal weight obesity (NWO)], have a higher prevalence of cardiometabolic dysregulation and are at higher risk for cardiovascular (CV) mortality.We analysed 6171 subjects >20 years of age from the Third National Health and Nutrition Examination Survey (NHANES III) and the NHANES III mortality study, whose BMI was within the normal range (18.5-24.9 kg/m(2)), and who underwent a complete evaluation that included body composition assessment, blood measurements, and assessment of CV risk factors. Survival information was available for >99% of the subjects after a median follow-up of 8.8 years. We divided our sample using sex-specific tertiles of BF%. The highest tertile of BF (>23.1% in men and >33.3% in women) was labelled as NWO. When compared with the low BF group, the prevalence of metabolic syndrome in subjects with NWO was four-fold higher (16.6 vs. 4.8%, P < 0.0001). Subjects with NWO also had higher prevalence of dyslipidaemia, hypertension (men), and CV disease (women). After adjustment, women with NWO showed a significant 2.2-fold increased risk for CV mortality (HR = 2.2; 95% CI, 1.03-4.67) in comparison to the low BF group.METHODS AND RESULTSWe analysed 6171 subjects >20 years of age from the Third National Health and Nutrition Examination Survey (NHANES III) and the NHANES III mortality study, whose BMI was within the normal range (18.5-24.9 kg/m(2)), and who underwent a complete evaluation that included body composition assessment, blood measurements, and assessment of CV risk factors. Survival information was available for >99% of the subjects after a median follow-up of 8.8 years. We divided our sample using sex-specific tertiles of BF%. The highest tertile of BF (>23.1% in men and >33.3% in women) was labelled as NWO. When compared with the low BF group, the prevalence of metabolic syndrome in subjects with NWO was four-fold higher (16.6 vs. 4.8%, P < 0.0001). Subjects with NWO also had higher prevalence of dyslipidaemia, hypertension (men), and CV disease (women). After adjustment, women with NWO showed a significant 2.2-fold increased risk for CV mortality (HR = 2.2; 95% CI, 1.03-4.67) in comparison to the low BF group.Normal weight obesity, defined as the combination of normal BMI and high BF content, is associated with a high prevalence of cardiometabolic dysregulation, metabolic syndrome, and CV risk factors. In women, NWO is independently associated with increased risk for CV mortality.CONCLUSIONNormal weight obesity, defined as the combination of normal BMI and high BF content, is associated with a high prevalence of cardiometabolic dysregulation, metabolic syndrome, and CV risk factors. In women, NWO is independently associated with increased risk for CV mortality. We hypothesized that subjects with a normal body mass index (BMI), but high body fat (BF) content [normal weight obesity (NWO)], have a higher prevalence of cardiometabolic dysregulation and are at higher risk for cardiovascular (CV) mortality. We analysed 6171 subjects >20 years of age from the Third National Health and Nutrition Examination Survey (NHANES III) and the NHANES III mortality study, whose BMI was within the normal range (18.5-24.9 kg/m(2)), and who underwent a complete evaluation that included body composition assessment, blood measurements, and assessment of CV risk factors. Survival information was available for >99% of the subjects after a median follow-up of 8.8 years. We divided our sample using sex-specific tertiles of BF%. The highest tertile of BF (>23.1% in men and >33.3% in women) was labelled as NWO. When compared with the low BF group, the prevalence of metabolic syndrome in subjects with NWO was four-fold higher (16.6 vs. 4.8%, P < 0.0001). Subjects with NWO also had higher prevalence of dyslipidaemia, hypertension (men), and CV disease (women). After adjustment, women with NWO showed a significant 2.2-fold increased risk for CV mortality (HR = 2.2; 95% CI, 1.03-4.67) in comparison to the low BF group. Normal weight obesity, defined as the combination of normal BMI and high BF content, is associated with a high prevalence of cardiometabolic dysregulation, metabolic syndrome, and CV risk factors. In women, NWO is independently associated with increased risk for CV mortality.
Author	Korinek, Josef Romero-Corral, Abel Somers, Virend K Sierra-Johnson, Justo Parati, Gianfranco Lopez-Jimenez, Francisco Jensen, Michael D Korenfeld, Yoel Boarin, Simona
Author_xml	– sequence: 1 givenname: Abel surname: Romero-Corral fullname: Romero-Corral, Abel organization: Mayo Clinic College of Medicine, Rochester, MN, USA – sequence: 2 givenname: Virend K surname: Somers fullname: Somers, Virend K – sequence: 3 givenname: Justo surname: Sierra-Johnson fullname: Sierra-Johnson, Justo – sequence: 4 givenname: Yoel surname: Korenfeld fullname: Korenfeld, Yoel – sequence: 5 givenname: Simona surname: Boarin fullname: Boarin, Simona – sequence: 6 givenname: Josef surname: Korinek fullname: Korinek, Josef – sequence: 7 givenname: Michael D surname: Jensen fullname: Jensen, Michael D – sequence: 8 givenname: Gianfranco surname: Parati fullname: Parati, Gianfranco – sequence: 9 givenname: Francisco surname: Lopez-Jimenez fullname: Lopez-Jimenez, Francisco
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/19933515$$D View this record in MEDLINE/PubMed
BookMark	eNpNkE1Lw0AQhhep2A-9e5K9eYrNbvYr3qT4BUUveg6zm0mbmmTrbqL03xuwgofhHV4eHoaZk0nnOyTkkqU3LM2zJQ5hixD63RK3e2H0CZkxyXmSKyEn__Ypmce4S9PUKKbOyJTleZZJJmfEvfjQQkO_sd5se-otxro_3FKgoY4ftALX-0CrcRyEsvYt9mB9UztaHmLAzdBAX_uOQlceiS-IbmwDbX3ooRlt5-S0gibixTEX5P3h_m31lKxfH59Xd-vECSF0ori2UiJwDkaXgoGFkhujUY93S2Wwstqiq4wCI0RpIM9BOpU7xYSxlvEFuf717oP_HDD2RVtHh00DHfohFjrLNMtSrkby6kgOtsWy2Ie6hXAo_v7CfwCiRGrl
CitedBy_id	crossref_primary_10_1016_j_clnesp_2022_01_017 crossref_primary_10_1186_s40795_024_00931_0 crossref_primary_10_1161_CIR_0b013e318233bc6a crossref_primary_10_1186_s12889_022_13381_9 crossref_primary_10_3390_jcm13082314 crossref_primary_10_1097_HCR_0b013e31828254fc crossref_primary_10_1186_1471_2458_11_383 crossref_primary_10_1080_03014460_2018_1546900 crossref_primary_10_1371_journal_pone_0282433 crossref_primary_10_1093_ajcn_nqy006 crossref_primary_10_1016_j_ejim_2014_05_008 crossref_primary_10_1111_cen_12162 crossref_primary_10_1016_j_rec_2010_10_011 crossref_primary_10_1371_journal_pone_0175057 crossref_primary_10_1016_j_ijcard_2012_01_089 crossref_primary_10_1111_jgs_13542 crossref_primary_10_1038_ejcn_2013_282 crossref_primary_10_1002_fsn3_853 crossref_primary_10_1016_j_nutres_2023_10_008 crossref_primary_10_1097_AIA_0000000000000278 crossref_primary_10_1097_YPG_0000000000000181 crossref_primary_10_1007_s40618_013_0048_3 crossref_primary_10_4065_mcp_2010_0583 crossref_primary_10_1016_j_clnu_2024_09_020 crossref_primary_10_1016_j_nut_2016_10_009 crossref_primary_10_1016_j_diabet_2017_04_005 crossref_primary_10_3389_fpubh_2023_1086771 crossref_primary_10_1016_j_clnesp_2020_12_009 crossref_primary_10_1038_s41598_023_49039_8 crossref_primary_10_1186_s40200_016_0239_5 crossref_primary_10_3390_metabo15080550 crossref_primary_10_1016_j_clinthera_2020_06_007 crossref_primary_10_1371_journal_pone_0237974 crossref_primary_10_5812_zjrms_123783 crossref_primary_10_1097_MCO_0b013e32834ad8b6 crossref_primary_10_3390_sports12040091 crossref_primary_10_1111_cob_12523 crossref_primary_10_1111_eci_70059 crossref_primary_10_3389_fpubh_2017_00290 crossref_primary_10_4103_ijpvm_IJPVM_392_20 crossref_primary_10_1186_s12933_015_0220_5 crossref_primary_10_1007_s10753_010_9219_y crossref_primary_10_1007_s13105_020_00781_x crossref_primary_10_1097_MCA_0000000000000369 crossref_primary_10_3390_jcm8122147 crossref_primary_10_1002_acr_20343 crossref_primary_10_1002_smi_2760 crossref_primary_10_1016_j_jcte_2021_100257 crossref_primary_10_1186_s12889_025_23891_x crossref_primary_10_1016_j_mcna_2017_08_007 crossref_primary_10_1038_ejcn_2013_142 crossref_primary_10_1016_j_ejogrb_2024_09_024 crossref_primary_10_3390_metabo13101056 crossref_primary_10_1038_s41598_023_44217_0 crossref_primary_10_1016_j_glohj_2023_03_001 crossref_primary_10_1016_j_ajt_2023_04_025 crossref_primary_10_1016_j_metabol_2015_09_005 crossref_primary_10_1186_s12889_020_08630_8 crossref_primary_10_1016_j_numecd_2010_10_007 crossref_primary_10_1007_s00774_023_01417_y crossref_primary_10_1007_s00129_014_3474_1 crossref_primary_10_1007_s40519_021_01109_4 crossref_primary_10_1177_0972558X231187509 crossref_primary_10_3390_healthcare11162303 crossref_primary_10_1371_journal_pone_0316346 crossref_primary_10_4102_jir_v1i1_18 crossref_primary_10_1097_MD_0000000000001705 crossref_primary_10_1159_000525545 crossref_primary_10_3389_fped_2018_00371 crossref_primary_10_1186_s12916_021_01972_z crossref_primary_10_3389_fpubh_2017_00190 crossref_primary_10_1158_1940_6207_CAPR_20_0633 crossref_primary_10_1097_MS9_0000000000000428 crossref_primary_10_1016_j_jacadv_2025_101788 crossref_primary_10_1152_physrev_00007_2014 crossref_primary_10_1111_vaa_12219 crossref_primary_10_1016_j_orcp_2012_02_002 crossref_primary_10_5812_ijem_7963 crossref_primary_10_1371_journal_pone_0106134 crossref_primary_10_1016_j_numecd_2015_10_001 crossref_primary_10_1155_2013_983424 crossref_primary_10_1007_s40618_021_01616_2 crossref_primary_10_3390_nu9080822 crossref_primary_10_4065_mcp_2011_0156 crossref_primary_10_3390_jfmk7040092 crossref_primary_10_1038_nutd_2016_30 crossref_primary_10_1038_s41366_018_0020_6 crossref_primary_10_1155_2013_754815 crossref_primary_10_1016_j_anai_2025_03_009 crossref_primary_10_1007_s11883_014_0464_7 crossref_primary_10_1002_lite_201400022 crossref_primary_10_1016_j_clnu_2013_03_014 crossref_primary_10_1093_chemse_bjv040 crossref_primary_10_1155_2012_634048 crossref_primary_10_1016_j_procs_2024_09_569 crossref_primary_10_2147_DMSO_S330194 crossref_primary_10_1038_ijo_2011_100 crossref_primary_10_1097_MNH_0b013e3283414ca1 crossref_primary_10_1016_j_ypmed_2016_08_001 crossref_primary_10_1002_ijc_30684 crossref_primary_10_1161_CIR_0000000000000973 crossref_primary_10_1080_14635240_2012_724190 crossref_primary_10_3390_nu14153071 crossref_primary_10_1530_EJE_17_0868 crossref_primary_10_3390_medsci2030140 crossref_primary_10_1007_s00592_018_1118_y crossref_primary_10_1016_j_urolonc_2024_11_002 crossref_primary_10_1155_2013_363728 crossref_primary_10_1097_DCR_0000000000000876 crossref_primary_10_5812_ijem_13569 crossref_primary_10_1155_2012_123610 crossref_primary_10_1038_ijo_2010_5 crossref_primary_10_1038_ejcn_2014_66 crossref_primary_10_1186_s12902_020_00648_8 crossref_primary_10_3389_fimmu_2020_00245 crossref_primary_10_1155_2021_1607475 crossref_primary_10_1016_j_physbeh_2016_10_009 crossref_primary_10_1186_s13044_019_0070_4 crossref_primary_10_2478_joeb_2018_0005 crossref_primary_10_1186_s40246_016_0065_3 crossref_primary_10_1016_j_ejim_2017_10_020 crossref_primary_10_1002_osp4_4 crossref_primary_10_1038_nutd_2014_46 crossref_primary_10_1038_s41430_018_0107_0 crossref_primary_10_1007_s40519_015_0215_y crossref_primary_10_1371_journal_pone_0033308 crossref_primary_10_1108_NFS_12_2023_0286 crossref_primary_10_1093_occmed_kqs213 crossref_primary_10_1371_journal_pone_0132959 crossref_primary_10_1016_j_puhe_2023_11_012 crossref_primary_10_3233_JAD_180264 crossref_primary_10_3109_10641963_2013_764886 crossref_primary_10_4065_mcp_2010_0624 crossref_primary_10_1007_s43465_025_01355_z crossref_primary_10_1088_1742_6596_434_1_012063 crossref_primary_10_3389_fendo_2023_1128076 crossref_primary_10_3390_nu16142216 crossref_primary_10_2147_DMSO_S325115 crossref_primary_10_4330_wjc_v17_i8_108749 crossref_primary_10_1097_NT_0000000000000092 crossref_primary_10_3390_nu5062019 crossref_primary_10_1016_j_numecd_2018_06_015 crossref_primary_10_1007_s11883_013_0364_2 crossref_primary_10_1186_s12986_015_0037_y crossref_primary_10_2196_63280 crossref_primary_10_1017_S0007114520004882 crossref_primary_10_1111_j_1467_789X_2012_01052_x crossref_primary_10_3390_nu12123792 crossref_primary_10_1186_s12944_024_02247_1 crossref_primary_10_3390_ijerph182111439 crossref_primary_10_3390_nu14245295 crossref_primary_10_1038_s41598_023_30527_w crossref_primary_10_1007_s00421_023_05344_8 crossref_primary_10_1016_j_clinthera_2019_05_016 crossref_primary_10_3109_02713683_2014_975367 crossref_primary_10_3389_fimmu_2023_1044178 crossref_primary_10_1371_journal_pone_0088118 crossref_primary_10_1016_j_accpm_2022_101086 crossref_primary_10_33920_med_03_2501_04 crossref_primary_10_1016_j_numecd_2016_11_123 crossref_primary_10_1016_j_orcp_2022_08_008 crossref_primary_10_1038_s41598_024_71202_y crossref_primary_10_1177_8756479317747210 crossref_primary_10_1111_dom_12217 crossref_primary_10_1210_jc_2013_2832 crossref_primary_10_1007_s00592_024_02317_x crossref_primary_10_1080_14779072_2019_1581064 crossref_primary_10_1038_s41598_018_34602_5 crossref_primary_10_1016_j_cgh_2017_04_045 crossref_primary_10_4103_aja2024119 crossref_primary_10_1186_s12891_018_2175_7 crossref_primary_10_1038_ijo_2010_257 crossref_primary_10_1016_j_clnu_2024_12_027 crossref_primary_10_1017_S0007114522000307 crossref_primary_10_4103_ijmr_IJMR_1768_17 crossref_primary_10_3390_ijerph17010036 crossref_primary_10_1016_j_ypmed_2013_12_014 crossref_primary_10_3390_nu17091475 crossref_primary_10_1097_CRD_0000000000000004 crossref_primary_10_1186_s40200_017_0330_6 crossref_primary_10_12998_wjcc_v12_i7_1215 crossref_primary_10_1371_journal_pone_0223664 crossref_primary_10_3390_ijerph191811747 crossref_primary_10_1136_bmjdrc_2022_003013 crossref_primary_10_1111_ijpo_242 crossref_primary_10_1088_1742_6596_407_1_012005 crossref_primary_10_1002_dmrr_3725 crossref_primary_10_2337_cd17_0066 crossref_primary_10_1177_1474515118761870 crossref_primary_10_1038_s41598_022_17837_1 crossref_primary_10_1016_j_numecd_2024_08_001 crossref_primary_10_1016_j_numecd_2022_05_020 crossref_primary_10_1002_jcsm_13644 crossref_primary_10_1002_mnfr_202200503 crossref_primary_10_1016_j_mmm_2025_05_007 crossref_primary_10_1177_1559827616654103 crossref_primary_10_1007_s12325_025_03352_y crossref_primary_10_1186_s40748_018_0079_z crossref_primary_10_1111_jgh_12861 crossref_primary_10_1210_clinem_dgad152 crossref_primary_10_1371_journal_pone_0328992 crossref_primary_10_1038_s41366_021_00858_7 crossref_primary_10_1089_met_2023_0154 crossref_primary_10_1186_s40101_016_0115_5 crossref_primary_10_1016_j_hbpd_2020_02_010 crossref_primary_10_1007_s10304_013_0585_z crossref_primary_10_3389_fendo_2025_1523731 crossref_primary_10_2147_DMSO_S508067 crossref_primary_10_1007_s11892_020_01302_2 crossref_primary_10_1017_S1368980020004863 crossref_primary_10_1080_10256016_2020_1860958 crossref_primary_10_1111_jcpe_12196 crossref_primary_10_1136_bmjgast_2019_000322 crossref_primary_10_3390_nu16162579 crossref_primary_10_1016_j_maturitas_2015_04_011 crossref_primary_10_1002_oby_22654 crossref_primary_10_1055_a_1891_3588 crossref_primary_10_1007_s00259_015_3087_5 crossref_primary_10_1007_s40656_024_00630_w crossref_primary_10_1038_ijo_2017_267 crossref_primary_10_1155_2017_9502643 crossref_primary_10_3390_healthcare12111142 crossref_primary_10_1071_PY18166 crossref_primary_10_1016_j_apmr_2011_12_024 crossref_primary_10_1093_eurjpc_zwad101 crossref_primary_10_1007_s13410_015_0373_5 crossref_primary_10_1186_s40064_015_0916_8 crossref_primary_10_1371_journal_pone_0161451 crossref_primary_10_1186_s12986_020_00464_w crossref_primary_10_1016_j_amepre_2014_11_007 crossref_primary_10_12688_f1000research_13897_1 crossref_primary_10_12688_f1000research_13897_2 crossref_primary_10_1016_j_mcna_2017_04_012 crossref_primary_10_1038_s41366_022_01165_5 crossref_primary_10_32725_kont_2022_005 crossref_primary_10_1038_s41598_019_38804_3 crossref_primary_10_1007_s13679_015_0161_z crossref_primary_10_1007_s00394_014_0716_x crossref_primary_10_12688_f1000research_13897_3 crossref_primary_10_1093_eurjpc_zwac046 crossref_primary_10_1186_s12889_015_2654_9 crossref_primary_10_1371_journal_pone_0286139 crossref_primary_10_1002_oby_21307 crossref_primary_10_1186_s12889_020_08832_0 crossref_primary_10_1016_j_jacc_2016_06_072 crossref_primary_10_1016_j_lana_2022_100215 crossref_primary_10_1038_s41569_023_00847_5 crossref_primary_10_1007_s00467_020_04716_y crossref_primary_10_1093_eurheartj_ehz391 crossref_primary_10_1007_s12603_015_0508_x crossref_primary_10_4162_nrp_2021_15_5_604 crossref_primary_10_21101_cejph_a5133 crossref_primary_10_1038_s41598_019_41986_5 crossref_primary_10_1016_j_amepre_2015_05_025 crossref_primary_10_1093_nutrit_nuu007 crossref_primary_10_3390_ijerph15122748 crossref_primary_10_1155_2015_158758 crossref_primary_10_15857_ksep_2022_00318 crossref_primary_10_1016_j_lfs_2019_03_022 crossref_primary_10_1007_s11695_021_05470_2 crossref_primary_10_1080_07853890_2024_2403721 crossref_primary_10_1186_1475_2840_13_54 crossref_primary_10_1111_1753_0407_12416 crossref_primary_10_7326_M14_2525 crossref_primary_10_3390_ijerph19116740 crossref_primary_10_1016_j_pcd_2021_05_003 crossref_primary_10_1111_nep_13868 crossref_primary_10_3390_nu12041106 crossref_primary_10_1093_nutrit_nuw019 crossref_primary_10_5372_1905_7415_0805_331 crossref_primary_10_1371_journal_pone_0060673 crossref_primary_10_1016_j_ejim_2015_11_020 crossref_primary_10_1111_dmcn_13714 crossref_primary_10_1089_met_2017_0152 crossref_primary_10_1136_bmjopen_2017_019200 crossref_primary_10_1038_srep30329 crossref_primary_10_1186_s12877_019_1037_y crossref_primary_10_3389_fpubh_2022_941086 crossref_primary_10_1016_j_nutres_2024_01_009 crossref_primary_10_1007_s11845_020_02403_3 crossref_primary_10_1016_j_apmr_2014_03_029 crossref_primary_10_1002_oby_20020 crossref_primary_10_1186_s12872_023_03126_w crossref_primary_10_1016_j_envres_2025_121059 crossref_primary_10_1038_s41416_024_02906_1 crossref_primary_10_1097_HCR_0000000000000052 crossref_primary_10_1155_2013_489187 crossref_primary_10_1007_s11845_015_1338_x crossref_primary_10_1136_bmjopen_2016_013831 crossref_primary_10_1016_j_ecl_2024_10_005 crossref_primary_10_3390_ijerph182111070 crossref_primary_10_1210_clinem_dgaa166 crossref_primary_10_1016_j_ccm_2018_01_002 crossref_primary_10_1007_s00592_021_01806_7 crossref_primary_10_4162_nrp_2021_15_1_95 crossref_primary_10_1097_JOM_0b013e31820af362 crossref_primary_10_1016_j_ijcard_2011_10_006 crossref_primary_10_1038_s41366_021_00926_y crossref_primary_10_1186_1475_2840_13_70 crossref_primary_10_1016_j_clnme_2012_02_006 crossref_primary_10_1007_s13679_025_00641_z crossref_primary_10_1017_S1368980017001045 crossref_primary_10_5888_pcd22_250222 crossref_primary_10_3390_ijerph22010103 crossref_primary_10_1007_s12630_012_9760_2 crossref_primary_10_1016_j_ctim_2019_102211 crossref_primary_10_1017_S0007114520002019 crossref_primary_10_1038_s41367_020_0017_1 crossref_primary_10_1016_j_metabol_2013_01_006 crossref_primary_10_1371_journal_pone_0298662 crossref_primary_10_1016_j_numecd_2010_11_009 crossref_primary_10_3390_nu16081197 crossref_primary_10_1186_s12944_023_01784_5 crossref_primary_10_1038_s41598_021_85573_z crossref_primary_10_1007_s00380_020_01648_3 crossref_primary_10_1111_eci_12106 crossref_primary_10_1097_HCR_0b013e31827fe7e3 crossref_primary_10_1007_s11154_023_09813_5 crossref_primary_10_1515_ijamh_2015_0042 crossref_primary_10_1177_1098612X18780872 crossref_primary_10_3389_fnut_2023_1173488 crossref_primary_10_1007_s11095_010_0341_1 crossref_primary_10_1097_HJH_0000000000001297 crossref_primary_10_3389_fendo_2022_857930 crossref_primary_10_1017_S0021932019000403 crossref_primary_10_1093_ajh_hpu153 crossref_primary_10_1186_s12889_021_10399_3 crossref_primary_10_1007_s40519_016_0278_4 crossref_primary_10_1017_S0007114510002096 crossref_primary_10_15857_ksep_2021_30_1_70 crossref_primary_10_1016_j_exger_2025_112724 crossref_primary_10_1016_j_jand_2020_07_020 crossref_primary_10_1038_oby_2011_36 crossref_primary_10_1007_s00268_022_06769_6 crossref_primary_10_1007_s44411_025_00273_8 crossref_primary_10_1038_s41598_019_53557_9 crossref_primary_10_1016_j_amjcard_2017_05_054 crossref_primary_10_1016_j_mayocp_2012_08_008 crossref_primary_10_56984_8ZG7D19BEN9 crossref_primary_10_1016_j_amjcard_2013_07_014 crossref_primary_10_1038_ijo_2015_243 crossref_primary_10_1038_srep27769 crossref_primary_10_1093_ndt_gft024 crossref_primary_10_3389_fnut_2022_982519 crossref_primary_10_1038_s41366_020_0548_0 crossref_primary_10_1016_j_ypmed_2015_11_015 crossref_primary_10_3389_fnut_2023_1239996 crossref_primary_10_1177_1747493018816425 crossref_primary_10_3389_fcvm_2021_717257 crossref_primary_10_3390_children8010018 crossref_primary_10_1016_j_curtheres_2013_10_002 crossref_primary_10_1161_CIRCIMAGING_111_969956 crossref_primary_10_2147_DMSO_S280350 crossref_primary_10_1016_j_jtemb_2024_127538 crossref_primary_10_3390_obesities5030061 crossref_primary_10_1093_eurjpc_zwae171 crossref_primary_10_1016_j_pcad_2013_10_003 crossref_primary_10_1038_nrcardio_2010_209 crossref_primary_10_1080_10920277_2016_1241183 crossref_primary_10_1016_j_gheart_2015_12_010 crossref_primary_10_1080_08952841_2021_1877098 crossref_primary_10_1089_met_2022_0026 crossref_primary_10_1038_s41598_025_10583_0 crossref_primary_10_1136_heartasia_2015_010644 crossref_primary_10_1016_j_amjcard_2018_11_043 crossref_primary_10_1016_j_metabol_2015_10_027 crossref_primary_10_1155_2014_204295 crossref_primary_10_1007_s13410_016_0543_0 crossref_primary_10_1016_j_puhe_2019_10_017 crossref_primary_10_1016_j_amjcard_2010_09_034 crossref_primary_10_1097_MCO_0000000000000317 crossref_primary_10_1097_CRD_0000000000000984 crossref_primary_10_1186_s13148_018_0515_y crossref_primary_10_1016_j_numecd_2016_09_003 crossref_primary_10_1016_j_amepre_2016_11_027 crossref_primary_10_1186_s12986_021_00562_3 crossref_primary_10_3389_fpsyt_2022_831358 crossref_primary_10_1371_journal_pone_0112639 crossref_primary_10_1111_jch_14666 crossref_primary_10_1161_CIRCRESAHA_111_262493 crossref_primary_10_1016_j_jesf_2024_10_002 crossref_primary_10_1016_j_orcp_2016_02_005 crossref_primary_10_1155_2014_743634 crossref_primary_10_3390_nu16172874 crossref_primary_10_1002_ajhb_24043 crossref_primary_10_1093_jn_nxaa328 crossref_primary_10_1016_j_beem_2013_01_004 crossref_primary_10_1089_chi_2019_0122 crossref_primary_10_1519_JSC_0000000000004064 crossref_primary_10_3109_00365513_2013_821712 crossref_primary_10_3390_jcm12052066 crossref_primary_10_5888_pcd17_200020 crossref_primary_10_1016_j_trre_2024_100852 crossref_primary_10_1002_dmrr_3135 crossref_primary_10_1016_j_preghy_2025_101249 crossref_primary_10_2337_dc12_2312 crossref_primary_10_14814_phy2_70107 crossref_primary_10_1111_j_1758_8111_2011_00016_x crossref_primary_10_1515_ijamh_2020_0240 crossref_primary_10_1097_PR9_0000000000000916 crossref_primary_10_1016_j_jacc_2012_10_035 crossref_primary_10_1016_j_clnu_2017_07_002 crossref_primary_10_3748_wjg_v22_i2_681 crossref_primary_10_1186_s12889_018_6238_3 crossref_primary_10_1186_s12981_024_00599_3 crossref_primary_10_1016_j_nut_2021_111515 crossref_primary_10_1016_j_appet_2018_01_003 crossref_primary_10_1111_jch_13668 crossref_primary_10_1111_jch_13667 crossref_primary_10_1111_j_1755_5949_2011_00271_x crossref_primary_10_1002_osp4_70022
ContentType	Journal Article
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1093/eurheartj/ehp487
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
EISSN	1522-9645
ExternalDocumentID	19933515
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NHLBI NIH HHS grantid: HL-70302 – fundername: NHLBI NIH HHS grantid: HL-65176 – fundername: NHLBI NIH HHS grantid: HL-73211 – fundername: NCRR NIH HHS grantid: M01-RR00585
GroupedDBID	--- --K -E4 .2P .GJ .I3 .XZ .ZR 08P 0R~ 18M 1B1 1TH 29G 2WC 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 70D AABZA AACZT AAFWJ AAJKP AAJQQ AAMVS AAOGV AAPGJ AAPNW AAPQZ AAPXW AARHZ AAUAY AAUQX AAVAP AAWDT ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABNGD ABNHQ ABNKS ABOCM ABPQP ABPTD ABQLI ABQNK ABSMQ ABVGC ABWST ABXVV ABZBJ ACFRR ACGFO ACGFS ACPQN ACPRK ACUFI ACUKT ACUTJ ACUTO ACVCV ACYHN ACZBC ADBBV ADEYI ADEZT ADGHP ADGZP ADHKW ADHZD ADIPN ADMTO ADNBA ADOCK ADQBN ADRTK ADVEK ADYVW ADZXQ AEGPL AEGXH AEHUL AEJOX AEKPW AEKSI AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEWNT AFFNX AFFQV AFFZL AFIYH AFOFC AFSHK AFXAL AFYAG AGINJ AGKEF AGKRT AGMDO AGORE AGQPQ AGQXC AGSYK AGUTN AHGBF AHMBA AHMMS AHXPO AI. AIAGR AIJHB AJBYB AJDVS AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APJGH APWMN AQDSO AQKUS ASPBG ATGXG ATTQO AVNTJ AVWKF AXUDD AZFZN BAWUL BAYMD BCGUY BCRHZ BEYMZ BHONS BTRTY BVRKM BZKNY C1A C45 CAG CDBKE CGR COF CS3 CUY CVF CZ4 DAKXR DIK DILTD D~K E3Z EBS ECM EE~ EIF EIHJH EJD EMOBN ENERS F5P F9B FECEO FEDTE FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HVGLF HW0 HZ~ IHE IOX J21 JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN L7B M-Z M41 MBLQV MHKGH ML0 N4W N9A NGC NOMLY NOYVH NPM NQ- NTWIH NU- NVLIB O0~ O9- OAUYM OAWHX OB3 OBFPC OCZFY ODMLO OGROG OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P2P PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RIG RNI ROL ROX ROZ RPZ RUSNO RW1 RXO RZF SEL TCURE TEORI TJX TMA UHS VH1 W8F WOQ X7H YAYTL YKOAZ YXANX ZGI ZKX ~91 7X8
ID	FETCH-LOGICAL-c4447-627b55ea22a87d41abad2887e7008568efb7becf86a844d8a99a5c69c6148bb12
IEDL.DBID	7X8
ISSN	1522-9645
IngestDate	Sat Sep 27 18:00:13 EDT 2025 Mon Jul 21 05:56:15 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	6
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c4447-627b55ea22a87d41abad2887e7008568efb7becf86a844d8a99a5c69c6148bb12
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://academic.oup.com/eurheartj/article-pdf/31/6/737/17892748/ehp487.pdf
PMID	19933515
PQID	733713026
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_733713026 pubmed_primary_19933515
PublicationCentury	2000
PublicationDate	2010-03-00
PublicationDateYYYYMMDD	2010-03-01
PublicationDate_xml	– month: 03 year: 2010 text: 2010-03-00
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	European heart journal
PublicationTitleAlternate	Eur Heart J
PublicationYear	2010
SSID	ssj0008616
Score	2.5257053
Snippet	We hypothesized that subjects with a normal body mass index (BMI), but high body fat (BF) content [normal weight obesity (NWO)], have a higher prevalence of...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	737
SubjectTerms	Adipose Tissue - metabolism Adult Aged Body Composition - physiology Body Mass Index Cardiovascular Diseases - metabolism Cardiovascular Diseases - mortality Female Humans Male Metabolic Syndrome - mortality Middle Aged Obesity - metabolism Obesity - mortality Risk Factors United States - epidemiology Young Adult
Title	Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality
URI	https://www.ncbi.nlm.nih.gov/pubmed/19933515 https://www.proquest.com/docview/733713026
Volume	31
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwELaAIsTC-1Fe8sBqVU0c22FBCIFYGnUAqVvkJxS1SekDxL_n7LgwIQaWTEkU-c53X_x9ug-hS66hj6uuI6nLUkK5zonKpCKSUWO7QubOimA2wYtCDAZ5P2pzZlFWuayJoVCbWvsz8g5PU-5JNnY9eSPeNMqTq9FBYxW1UkAyPqn54GdYuGDB-RQ6VEJyRrPIUsI_fMcupt4wev7asS8TKvjv-DL0mfvtf37hDtqKABPfNBmxi1ZstYc2epFC30e68Ch1hD_CmSiuG2OAKyyxV5njxn8HA5TFOkhVx3YOeTIaamw-oZ0-R7svLCsT71iKWfE4QHl42wF6ur97vH0g0WmBaEopJyzhKsusTBIpuKFdqaRJoPxY7iEZE9YpDsF2gklBqYEQ5jLTLNd-jKhS3eQQrVV1ZY8R5olzqVEuM97WWjGlpNNKS6esBLCUthFerl4JmezpCVnZejErv9evjY6aCJSTZuJG6VWGKSCvk78fPkWbDcHvZWJnqOVgF9tztK7f58PZ9CJkCFyLfu8L6GzK8A
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Normal+weight+obesity%3A+a+risk+factor+for+cardiometabolic+dysregulation+and+cardiovascular+mortality&rft.jtitle=European+heart+journal&rft.au=Romero-Corral%2C+Abel&rft.au=Somers%2C+Virend+K&rft.au=Sierra-Johnson%2C+Justo&rft.au=Korenfeld%2C+Yoel&rft.date=2010-03-01&rft.issn=1522-9645&rft.eissn=1522-9645&rft.volume=31&rft.issue=6&rft.spage=737&rft_id=info:doi/10.1093%2Feurheartj%2Fehp487&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1522-9645&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1522-9645&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1522-9645&client=summon