Shear wave elastography: How well does it perform in chronic hepatitis D virus infection?

Hepatitis delta virus (HDV) infection is associated with accelerated progression of liver disease to cirrhosis. Shear wave elastography (SWE) is a non‐invasive evaluation method of liver fibrosis. Its performance in accurately characterizing HDV fibrosis compared to other noninvasive markers remains...

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Vydané v:Journal of viral hepatitis Ročník 29; číslo 12; s. 1127 - 1133
Hlavní autori: Yang, Alexander H., Yardeni, David, Hercun, Julian, Kleiner, David E., Ling, Alexander, Marko, Jamie, Heller, Theo, Koh, Christopher
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Wiley Subscription Services, Inc 01.12.2022
Predmet:
Biomarkers
Chronic infection
Cirrhosis
Elasticity Imaging Techniques - methods
Fibrosis
Hepatitis B
Hepatitis C
Hepatitis C - pathology
hepatitis D
Hepatitis D, Chronic - diagnosis
Hepatitis Delta Virus
Humans
Infections
Liver - diagnostic imaging
Liver - pathology
Liver cirrhosis
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver diseases
Patients
shear wave elastography
hepatitis B
hepatitis D
shear wave elastography
ISSN:1352-0504, 1365-2893, 1365-2893
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Popis
Shrnutí:Hepatitis delta virus (HDV) infection is associated with accelerated progression of liver disease to cirrhosis. Shear wave elastography (SWE) is a non‐invasive evaluation method of liver fibrosis. Its performance in accurately characterizing HDV fibrosis compared to other noninvasive markers remains unknown. We assessed the performance of SWE in patients with chronic HDV, Hepatitis B (HBV) and Hepatitis C (HCV) infection. Cirrhosis was determined by histology or clinical data. Area under receiver operator characteristics (AUROC) was used to assess diagnostic performance in identifying cirrhosis by SWE in comparison with Fibroscan® (VCTE) and serologic tests of fibrosis. 158 patients with chronic hepatitis (HDV:44%, HBV: 46% and HCV: 29%) were evaluated. Cirrhosis was diagnosed in 28 (17.7%) patients. Mean noninvasive fibrosis measurements for the HBV/HCV and HDV groups, respectively, were as follows: APRI: 0.73 ± 1.08 and 1.3 ± 1.38; FIB‐4: 1.90 ± 2.24 and 2.33 ± 2.24; VCTE: 8.9 ± 6.7 kPa vs 10.4 ± 5.3 kPa; SWE: 1.5 ± 0.2 m/s and 1.6 ± 0.2 m/s. The performance of SWE in detecting HDV‐induced cirrhosis (AUROC 0.84, 95% CI 0.71–0.97) was slightly lower than in HBV/HCV induced disease (AUROC 0.88, 95% CI 0.81–0.96). For HDV patients, the performance of SWE was comparable to VCTE and slightly better than APRI and FIB‐4 especially in APRI and FIB‐4 indeterminate zones. The overall less accurate performance of noninvasive markers in HDV in comparison with HBV and HCV may be a result of significant hepatic inflammation in HDV.
Bibliografia:Alexander H. Yang, David Yardeni should be considered joint first author
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AUTHOR CONTRIBUTIONS
All authors contributed to the writing and editing of the manuscript and approve the final version. AHY and DY involved in conception, collection of data, writing of manuscript, statistics, and approval of final draft. JH involved in conception, collection of data, and approval of final draft. DEK involved in review of liver tissue and approval of final draft. AL and JM involved in supervision of shear wave elastography and review of ultrasound, and approval of final draft. TH involved in senior supervision and approval of final draft. CK involved in conception, writing of manuscript, senior supervision, and approval of final draft.
ISSN:1352-0504
1365-2893
1365-2893
DOI:10.1111/jvh.13745