Posttranscriptional regulation of cancer traits by HuR

Cancer‐related gene expression programs are strongly influenced by posttranscriptional mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous HuR‐regulated mRNAs encode proteins implicated in carcinogenesis. Here, we review the collections of HuR target mRNAs that encod...

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Veröffentlicht in:	Wiley interdisciplinary reviews. RNA Jg. 1; H. 2; S. 214 - 229
Hauptverfasser:	Abdelmohsen, Kotb, Gorospe, Myriam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Hoboken, USA John Wiley & Sons, Inc 01.09.2010 Wiley Subscription Services, Inc
Schlagworte:	Adaptive Immunity - genetics Adaptive Immunity - physiology Angiogenesis Animals Cancer Carcinogenesis Cell Proliferation Cell survival Cell Survival - genetics Cell Survival - physiology ELAV Proteins - genetics ELAV Proteins - metabolism ELAV Proteins - physiology Gene expression Gene Expression Regulation, Neoplastic Humans HuR protein Medical prognosis Metastases Models, Biological Neoplasms - genetics Neoplasms - metabolism Post-transcription Proteins Quantitative Trait, Heritable RNA Processing, Post-Transcriptional RNA-binding protein
ISSN:	1757-7004, 1757-7012, 1757-7012
Online-Zugang:	Volltext
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