Posttranscriptional regulation of cancer traits by HuR

Cancer‐related gene expression programs are strongly influenced by posttranscriptional mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous HuR‐regulated mRNAs encode proteins implicated in carcinogenesis. Here, we review the collections of HuR target mRNAs that encod...

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Published in:Wiley interdisciplinary reviews. RNA Vol. 1; no. 2; pp. 214 - 229
Main Authors: Abdelmohsen, Kotb, Gorospe, Myriam
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.09.2010
Wiley Subscription Services, Inc
Subjects:
Adaptive Immunity - genetics
Adaptive Immunity - physiology
Angiogenesis
Animals
Cancer
Carcinogenesis
Cell Proliferation
Cell survival
Cell Survival - genetics
Cell Survival - physiology
ELAV Proteins - genetics
ELAV Proteins - metabolism
ELAV Proteins - physiology
Gene expression
Gene Expression Regulation, Neoplastic
Humans
HuR protein
Medical prognosis
Metastases
Models, Biological
Neoplasms - genetics
Neoplasms - metabolism
Post-transcription
Proteins
Quantitative Trait, Heritable
RNA Processing, Post-Transcriptional
RNA-binding protein
ISSN:1757-7004, 1757-7012, 1757-7012
Online Access:Get full text
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Summary:Cancer‐related gene expression programs are strongly influenced by posttranscriptional mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous HuR‐regulated mRNAs encode proteins implicated in carcinogenesis. Here, we review the collections of HuR target mRNAs that encode proteins responsible for implementing five major cancer traits. By interacting with specific mRNA subsets, HuR enhances the levels of proteins that (1) promote cell proliferation, (2) increase cell survival, (3) elevate local angiogenesis, (4) help the cancer cell evade immune recognition, and (5) facilitate cancer cell invasion and metastasis. We propose that HuR exerts a tumorigenic function by enabling these cancer phenotypes. We discuss evidence that links HuR to several specific cancers and suggests its potential usefulness in cancer diagnosis, prognosis, and therapy. Copyright © 2010 John Wiley & Sons, Ltd. This article is categorized under: RNA Turnover and Surveillance > Regulation of RNA Stability RNA in Disease and Development > RNA in Disease
Bibliography:ArticleID:WRNA4
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ISSN:1757-7004
1757-7012
1757-7012
DOI:10.1002/wrna.4