Evaluation of the Pharmacokinetic Drug Interaction of Capmatinib With Itraconazole and Rifampicin and Potential Impact on Renal Transporters in Healthy Subjects

Capmatinib is a highly specific, potent, and selective mesenchymal–epithelial transition factor inhibitor predominantly eliminated by cytochrome P450 (CYP) 3A4 and aldehyde oxidase. Here, we investigated the effects of a strong CYP3A inhibitor (itraconazole) and a strong CYP3A inducer (rifampicin) o...

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Vydané v:	Journal of clinical pharmacology Ročník 63; číslo 2; s. 228 - 238
Hlavní autori:	Cui, Xiaoming, Chen, Xinhui, Pognan, Nathalie, Sengupta, Tirtha, Rahmanzadeh, Gholamreza, Kornberger, Ruediger, Giovannini, Monica
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Wiley Subscription Services, Inc 01.02.2023 John Wiley and Sons Inc
Predmet:	Aldehyde oxidase Antifungal agents Area Under Curve capmatinib Creatinine CYP3A Cystatin C Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A Inhibitors - pharmacology Cytochrome P450 Drug interaction Drug Interactions drug‐drug interaction Healthy Volunteers Humans Itraconazole Itraconazole - pharmacokinetics Kidneys Mesenchyme Pharmacokinetics Plasma renal transporter rifampicin Rifampin Rifampin - pharmacokinetics serum creatinine CYP3A rifampicin renal transporter capmatinib pharmacokinetics itraconazole drug-drug interaction serum creatinine
ISSN:	0091-2700, 1552-4604, 1552-4604
On-line prístup:	Získať plný text
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