TYK2 :p.Pro1104Ala Variant Protects Against Autoimmunity by Modulating Immune Cell Levels

ABSTRACT The TYK2:p.Pro1104Ala (rs34536443) hypomorph variant has been associated with protection against numerous autoimmune disorders. Thus, its mechanism of action becomes of great interest. Here, consistent with the participation of activated immune cells in autoimmunity, we show that the varian...

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Vydáno v:	Immunology Ročník 174; číslo 4; s. 462 - 469
Hlavní autoři:	Steri, Maristella, Orrù, Valeria, Sidore, Carlo, Mulas, Antonella, Pitzalis, Maristella, Busonero, Fabio, Maschio, Andrea, Serra, Valentina, Dei, Mariano, Lai, Sandra, Virdis, Francesca, Lobina, Monia, Loizedda, Annalisa, Marongiu, Michele, Masala, Marco, Floris, Matteo, Curreli, Nicolò, Balaci, Lenuta, Loi, Francesco, Pilia, Maria Grazia, Delitala, Alessandro, Fiorillo, Edoardo, Schlessinger, David, Zoledziewska, Magdalena
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Wiley Subscription Services, Inc 01.04.2025 John Wiley and Sons Inc
Témata:	Autoimmune diseases Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmunity Autoimmunity - genetics Autoimmunity - immunology B-Lymphocytes - immunology CD4 antigen Female Humans immune cell levels Immune system immunophenotyping Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocytes Lymphocytes B Lymphocytes T Male naïve cells Original Therapeutic targets TYK2 TYK2 Kinase - genetics TYK2 Kinase - immunology Tyk2 protein immune cell levels TYK2 autoimmunity immunophenotyping naïve cells
ISSN:	0019-2805, 1365-2567, 1365-2567
On-line přístup:	Získat plný text
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