Immune triggers preceding neuralgic amyotrophy

Background and purpose Infections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type and frequency of the preceding agents is unknown. Methods This was a multicentre, prospective, observational, matched case–control study. NA wa...

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Veröffentlicht in:European journal of neurology Jg. 31; H. 12; S. e16462 - n/a
Hauptverfasser: Sparasci, Davide, Schilg‐Hafer, Lenka, Schreiner, Bettina, Scheidegger, Olivier, Peyer, Anne‐Kathrin, Lascano, Agustina Maria, Vicino, Alex, Décard, Bernhard Friedrich, Tsouni, Pinelopi, Humm, Andrea Monika, Pianezzi, Enea, Zezza, Giulia, Hundsberger, Thomas, Dietmann, Anelia, Jung, Hans H., Kuntzer, Thierry, Wilder‐Smith, Einar, Martinetti‐Lucchini, Gladys, Petrini, Orlando, Fontana, Stefano, Gowland, Peter, Niederhauser, Christoph, Gobbi, Claudio, Ripellino, Paolo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England John Wiley & Sons, Inc 01.12.2024
John Wiley and Sons Inc
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ISSN:1351-5101, 1468-1331, 1468-1331
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Abstract Background and purpose Infections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type and frequency of the preceding agents is unknown. Methods This was a multicentre, prospective, observational, matched case–control study. NA was diagnosed by neuromuscular experts according to validated clinical criteria and electrodiagnostic studies. Clinical data and biological samples of NA patients were collected within 90 days from disease onset between June 2018 and December 2023. All NA patients were asked about prior infection and vaccination in the month before disease onset. Serological tests for hepatitis E virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, Epstein–Barr virus, cytomegalovirus, parvovirus B19, varicella‐zoster virus, Borrelia burgdorferi, Mycoplasma pneumoniae and Bartonella henselae were performed in a central laboratory. Each case was matched with a healthy control for age, sex, place of residence and time of blood collection. Results Fifty‐seven patients and corresponding controls were included. The mean age was 45 years for both groups. NA onset was preceded by a symptomatic infectious trigger confirmed by microbiological tests in 15/57 (26.3%) patients. Coronavirus disease 2019 vaccination was considered a potential trigger in 7/57 (12.3%) subjects. An acute viral infection was associated with a bilateral involvement of the brachial plexus (p = 0.003, Cramèr's V = 0.43). Conclusions Confirmed immune triggers (infection or vaccination) preceded disease onset in 22/57 (38.6%) NA cases. We suggest to test NA patients in the acute phase for intracellular antigens, especially in the case of concomitant bilateral involvement and hepatitis.
AbstractList Background and purpose Infections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type and frequency of the preceding agents is unknown. Methods This was a multicentre, prospective, observational, matched case–control study. NA was diagnosed by neuromuscular experts according to validated clinical criteria and electrodiagnostic studies. Clinical data and biological samples of NA patients were collected within 90 days from disease onset between June 2018 and December 2023. All NA patients were asked about prior infection and vaccination in the month before disease onset. Serological tests for hepatitis E virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, Epstein–Barr virus, cytomegalovirus, parvovirus B19, varicella‐zoster virus, Borrelia burgdorferi, Mycoplasma pneumoniae and Bartonella henselae were performed in a central laboratory. Each case was matched with a healthy control for age, sex, place of residence and time of blood collection. Results Fifty‐seven patients and corresponding controls were included. The mean age was 45 years for both groups. NA onset was preceded by a symptomatic infectious trigger confirmed by microbiological tests in 15/57 (26.3%) patients. Coronavirus disease 2019 vaccination was considered a potential trigger in 7/57 (12.3%) subjects. An acute viral infection was associated with a bilateral involvement of the brachial plexus (p = 0.003, Cramèr's V = 0.43). Conclusions Confirmed immune triggers (infection or vaccination) preceded disease onset in 22/57 (38.6%) NA cases. We suggest to test NA patients in the acute phase for intracellular antigens, especially in the case of concomitant bilateral involvement and hepatitis.
Infections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type and frequency of the preceding agents is unknown. This was a multicentre, prospective, observational, matched case-control study. NA was diagnosed by neuromuscular experts according to validated clinical criteria and electrodiagnostic studies. Clinical data and biological samples of NA patients were collected within 90 days from disease onset between June 2018 and December 2023. All NA patients were asked about prior infection and vaccination in the month before disease onset. Serological tests for hepatitis E virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, Epstein-Barr virus, cytomegalovirus, parvovirus B19, varicella-zoster virus, Borrelia burgdorferi, Mycoplasma pneumoniae and Bartonella henselae were performed in a central laboratory. Each case was matched with a healthy control for age, sex, place of residence and time of blood collection. Fifty-seven patients and corresponding controls were included. The mean age was 45 years for both groups. NA onset was preceded by a symptomatic infectious trigger confirmed by microbiological tests in 15/57 (26.3%) patients. Coronavirus disease 2019 vaccination was considered a potential trigger in 7/57 (12.3%) subjects. An acute viral infection was associated with a bilateral involvement of the brachial plexus (p = 0.003, Cramèr's V = 0.43). Confirmed immune triggers (infection or vaccination) preceded disease onset in 22/57 (38.6%) NA cases. We suggest to test NA patients in the acute phase for intracellular antigens, especially in the case of concomitant bilateral involvement and hepatitis.
Background and purpose Infections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type and frequency of the preceding agents is unknown. Methods This was a multicentre, prospective, observational, matched case–control study. NA was diagnosed by neuromuscular experts according to validated clinical criteria and electrodiagnostic studies. Clinical data and biological samples of NA patients were collected within 90 days from disease onset between June 2018 and December 2023. All NA patients were asked about prior infection and vaccination in the month before disease onset. Serological tests for hepatitis E virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, Epstein–Barr virus, cytomegalovirus, parvovirus B19, varicella‐zoster virus, Borrelia burgdorferi, Mycoplasma pneumoniae and Bartonella henselae were performed in a central laboratory. Each case was matched with a healthy control for age, sex, place of residence and time of blood collection. Results Fifty‐seven patients and corresponding controls were included. The mean age was 45 years for both groups. NA onset was preceded by a symptomatic infectious trigger confirmed by microbiological tests in 15/57 (26.3%) patients. Coronavirus disease 2019 vaccination was considered a potential trigger in 7/57 (12.3%) subjects. An acute viral infection was associated with a bilateral involvement of the brachial plexus (p = 0.003, Cramèr's V = 0.43). Conclusions Confirmed immune triggers (infection or vaccination) preceded disease onset in 22/57 (38.6%) NA cases. We suggest to test NA patients in the acute phase for intracellular antigens, especially in the case of concomitant bilateral involvement and hepatitis.
Infections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type and frequency of the preceding agents is unknown.BACKGROUND AND PURPOSEInfections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type and frequency of the preceding agents is unknown.This was a multicentre, prospective, observational, matched case-control study. NA was diagnosed by neuromuscular experts according to validated clinical criteria and electrodiagnostic studies. Clinical data and biological samples of NA patients were collected within 90 days from disease onset between June 2018 and December 2023. All NA patients were asked about prior infection and vaccination in the month before disease onset. Serological tests for hepatitis E virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, Epstein-Barr virus, cytomegalovirus, parvovirus B19, varicella-zoster virus, Borrelia burgdorferi, Mycoplasma pneumoniae and Bartonella henselae were performed in a central laboratory. Each case was matched with a healthy control for age, sex, place of residence and time of blood collection.METHODSThis was a multicentre, prospective, observational, matched case-control study. NA was diagnosed by neuromuscular experts according to validated clinical criteria and electrodiagnostic studies. Clinical data and biological samples of NA patients were collected within 90 days from disease onset between June 2018 and December 2023. All NA patients were asked about prior infection and vaccination in the month before disease onset. Serological tests for hepatitis E virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, Epstein-Barr virus, cytomegalovirus, parvovirus B19, varicella-zoster virus, Borrelia burgdorferi, Mycoplasma pneumoniae and Bartonella henselae were performed in a central laboratory. Each case was matched with a healthy control for age, sex, place of residence and time of blood collection.Fifty-seven patients and corresponding controls were included. The mean age was 45 years for both groups. NA onset was preceded by a symptomatic infectious trigger confirmed by microbiological tests in 15/57 (26.3%) patients. Coronavirus disease 2019 vaccination was considered a potential trigger in 7/57 (12.3%) subjects. An acute viral infection was associated with a bilateral involvement of the brachial plexus (p = 0.003, Cramèr's V = 0.43).RESULTSFifty-seven patients and corresponding controls were included. The mean age was 45 years for both groups. NA onset was preceded by a symptomatic infectious trigger confirmed by microbiological tests in 15/57 (26.3%) patients. Coronavirus disease 2019 vaccination was considered a potential trigger in 7/57 (12.3%) subjects. An acute viral infection was associated with a bilateral involvement of the brachial plexus (p = 0.003, Cramèr's V = 0.43).Confirmed immune triggers (infection or vaccination) preceded disease onset in 22/57 (38.6%) NA cases. We suggest to test NA patients in the acute phase for intracellular antigens, especially in the case of concomitant bilateral involvement and hepatitis.CONCLUSIONSConfirmed immune triggers (infection or vaccination) preceded disease onset in 22/57 (38.6%) NA cases. We suggest to test NA patients in the acute phase for intracellular antigens, especially in the case of concomitant bilateral involvement and hepatitis.
Author Scheidegger, Olivier
Petrini, Orlando
Jung, Hans H.
Schreiner, Bettina
Ripellino, Paolo
Hundsberger, Thomas
Peyer, Anne‐Kathrin
Zezza, Giulia
Sparasci, Davide
Gowland, Peter
Dietmann, Anelia
Wilder‐Smith, Einar
Tsouni, Pinelopi
Pianezzi, Enea
Vicino, Alex
Humm, Andrea Monika
Lascano, Agustina Maria
Kuntzer, Thierry
Niederhauser, Christoph
Martinetti‐Lucchini, Gladys
Gobbi, Claudio
Décard, Bernhard Friedrich
Schilg‐Hafer, Lenka
Fontana, Stefano
AuthorAffiliation 1 Department of Neurology Neurocenter of Southern Switzerland EOC Lugano Switzerland
3 Department of Neurology University and Hospital Zurich Zurich Switzerland
11 Laboratory of Microbiology EOC Bellinzona Switzerland
6 Neurology Division, Department of Clinical Neuroscience, University Hospitals of Geneva and Faculty of Medicine University of Geneva Geneva Switzerland
2 Department of Neurology Cantonal Hospital St Gallen Switzerland
7 Nerve‐Muscle Unit, Neurology Service, Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne Lausanne Switzerland
5 Department of Neurology University Hospital and University of Basel Basel Switzerland
12 University of Applied Sciences and Arts of Southern Switzerland Bellinzona Switzerland
15 Institute for Infectious Diseases University of Bern Bern Switzerland
9 Department of Neurology Hôpital du Valais Sion Switzerland
8 Cantonal Hospital Lucerne Switzerland
4 Department of Neurology, Inselspital Bern University Hospital and
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/39364568$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1016_j_mehy_2025_111760
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Copyright_xml – notice: 2024 The Author(s). published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
– notice: 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
– notice: 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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ISSN 1351-5101
1468-1331
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Issue 12
Keywords infection
neuralgic amyotrophy
immune trigger
Parsonage–Turner syndrome
vaccination
Language English
License Attribution
2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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2021; 9
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2011; 3
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1972; 27
1993; 342
2020; 7
2018; 18
2009; 2009
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2021; 34
1948; 1
2003; 7
2019; 25
2002; 249
1988; 296
2022; 98
2022; 11
2006; 129
2012; 23
1983; 308
1998; 57
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Snippet Background and purpose Infections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type...
Infections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type and frequency of the...
Background and purpose Infections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type...
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StartPage e16462
SubjectTerms Adult
Aged
Biological properties
Biological samples
Brachial Plexus Neuritis - etiology
Case-Control Studies
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - immunology
COVID-19 Vaccines - immunology
Cytomegalovirus
Disease control
Epstein-Barr virus
Female
Hepatitis
HIV
Human immunodeficiency virus
Humans
immune trigger
Immunization
Immunology
infection
Infections
Male
Middle Aged
neuralgic amyotrophy
Neuromuscular system
Neuropathies
Original
Parsonage–Turner syndrome
Parvoviruses
Prospective Studies
Respiratory diseases
Serological tests
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Vaccination
Varicella
Viral diseases
Viral infections
Title Immune triggers preceding neuralgic amyotrophy
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