Dendritic spine loss in epileptogenic Type II focal cortical dysplasia: Role of enhanced classical complement pathway activation

Dendritic spines are the postsynaptic sites for most excitatory glutamatergic synapses. We previously demonstrated a severe spine loss and synaptic reorganization in human neocortices presenting Type II focal cortical dysplasia (FCD), a developmental malformation and frequent cause of drug‐resistant...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Brain pathology (Zurich, Switzerland) Ročník 33; číslo 3; s. e13141 - n/a
Hlavní autori:	Rossini, Laura, De Santis, Dalia, Cecchini, Erica, Cagnoli, Cinzia, Maderna, Emanuela, Cartelli, Daniele, Morgan, Bryan Paul, Torvell, Megan, Spreafico, Roberto, Giacomo, Roberta, Tassi, Laura, Curtis, Marco, Garbelli, Rita
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland John Wiley & Sons, Inc 01.05.2023 John Wiley and Sons Inc
Predmet:	Adult Complement Complement activation Complement component C1q Complement component C3 Complement Pathway, Classical dendritic spine Dendritic spines Dendritic Spines - pathology Dendritic structure Density Drug Resistant Epilepsy - pathology Dysplasia Electron microscopy Epilepsy Epilepsy - pathology Focal Cortical Dysplasia Glutamatergic transmission Golgi apparatus Hippocampus Humans Hybridization Immunohistochemistry Malformations of Cortical Development - pathology Microglia organotypic culture Patients Quantitation Sclerosis Subgroups Surgery Synapses Synaptogenesis Temporal lobe United States > US California epilepsy focal cortical dysplasia dendritic spine organotypic culture complement microglia
ISSN:	1015-6305, 1750-3639, 1750-3639
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!