Animal models of human colorectal cancer: Current status, uses and limitations

To make orthotopic colon cancer murine models a more clearly understood subject. The orthotopic tumor models have been found to be more relevant in replicating the human disease process as compared to heterotopic models, many techniques for making orthotopic colorectal murine models have been report...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG Vol. 21; no. 41; p. 11854
Main Authors: Mittal, Vijay K, Bhullar, Jasneet Singh, Jayant, Kumar
Format: Journal Article
Language:English
Published: United States 07.11.2015
Subjects:
Animals
Cell Line, Tumor
Cell Proliferation
Colorectal Neoplasms - pathology
Colorectal Neoplasms - secondary
Heterografts
Humans
Liver Neoplasms - secondary
Lung Neoplasms - secondary
Lymphatic Metastasis
Mice
Neoplasm Invasiveness
Neoplasm Transplantation
Neoplasms, Experimental - pathology
Neoplasms, Experimental - secondary
Tumor Burden
Animal model
Colon cancer
Colorectal cancer animal model
Colon cancer murine model
Orthotopic model
Colorectal cancer
Colon cancer animal model
Cancer model
Murine model
ISSN:2219-2840, 2219-2840
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Summary:To make orthotopic colon cancer murine models a more clearly understood subject. The orthotopic tumor models have been found to be more relevant in replicating the human disease process as compared to heterotopic models, many techniques for making orthotopic colorectal murine models have been reported. We evaluated the current literature for various reported orthotopic colon cancer models to understand their techniques, advantages and limitations. An extensive literature review was performed by searching the National Library of Medicine Database (PubMed) using MeSH terms animal model; colon cancer; orthotopic model; murine model. Twenty studies related to colon cancer orthotopic xenograft model were evaluated in detail and discussed here. The detailed analysis of all relevant reports on orthotopic model showed tumor take rate between 42%-100%. While models using the enema technique and minimally invasive technique have reported development of tumor from mucosa with tumor take rate between 87%-100% with metastasis in 76%-90%. Over the years, the increased understanding of the murine models of human colon cancer has resulted in the development of various models. Each reported model has some limitations. These latest models have opened up new doors for continuing cancer research for not only understanding the colon cancer pathogenesis but also aid in the development of newer chemotherapeutic drugs as they mimic the human disease closely.
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ISSN:2219-2840
2219-2840
DOI:10.3748/wjg.v21.i41.11854