Quantification of entry phenotypes of macrophage-tropic HIV-1 across a wide range of CD4 densities

Defining a macrophage-tropic phenotype for HIV-1 to assess a role in pathogenesis is complicated by the fact that HIV-1 isolates vary continuously in their ability to enter monocyte-derived macrophages (MDMs) in vitro, and MDMs vary in their ability to support HIV-1 entry. To overcome these limitati...

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Bibliographic Details
Published in:	Journal of virology Vol. 88; no. 4; p. 1858
Main Authors:	Joseph, Sarah B, Arrildt, Kathryn T, Swanstrom, Adrienne E, Schnell, Gretja, Lee, Benhur, Hoxie, James A, Swanstrom, Ronald
Format:	Journal Article
Language:	English
Published:	United States 01.02.2014
Subjects:	Biological Evolution CD4 Antigens - metabolism CD4-Positive T-Lymphocytes - virology Cloning, Molecular env Gene Products, Human Immunodeficiency Virus - cerebrospinal fluid env Gene Products, Human Immunodeficiency Virus - metabolism Flow Cytometry HEK293 Cells HIV-1 - genetics HIV-1 - metabolism HIV-1 - physiology Humans Luciferases Macrophages - virology Phenotype Virus Internalization
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
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