Alcoholism: a systemic proinflammatory condition
Excessive ethanol consumption affects virtually any organ, both by indirect and direct mechanisms. Considerable research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic mani...
Uložené v:
| Vydané v: | World journal of gastroenterology : WJG Ročník 20; číslo 40; s. 14660 |
|---|---|
| Hlavní autori: | , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
28.10.2014
|
| Predmet: | |
| ISSN: | 2219-2840, 2219-2840 |
| On-line prístup: | Zistit podrobnosti o prístupe |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Excessive ethanol consumption affects virtually any organ, both by indirect and direct mechanisms. Considerable research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic manifestations of alcoholism. These cytokines derive primarily from activated Kupffer cells exposed to Gram-negative intestinal bacteria, which reach the liver in supra-physiological amounts due to ethanol-mediated increased gut permeability. Reactive oxygen species (ROS) that enhance the inflammatory response are generated both by activation of Kupffer cells and by the direct metabolic effects of ethanol. The effects of this increased cytokine secretion and ROS generation lie far beyond liver damage. In addition to the classic consequences of endotoxemia associated with liver cirrhosis that were described several decades ago, important research in the last ten years has shown that cytokines may also induce damage in remote organs such as brain, bone, muscle, heart, lung, gonads, peripheral nerve, and pancreas. These effects are even seen in alcoholics without significant liver disease. Therefore, alcoholism can be viewed as an inflammatory condition, a concept which opens the possibility of using new therapeutic weapons to treat some of the complications of this devastating and frequent disease. In this review we examine some of the most outstanding consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver. |
|---|---|
| AbstractList | Excessive ethanol consumption affects virtually any organ, both by indirect and direct mechanisms. Considerable research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic manifestations of alcoholism. These cytokines derive primarily from activated Kupffer cells exposed to Gram-negative intestinal bacteria, which reach the liver in supra-physiological amounts due to ethanol-mediated increased gut permeability. Reactive oxygen species (ROS) that enhance the inflammatory response are generated both by activation of Kupffer cells and by the direct metabolic effects of ethanol. The effects of this increased cytokine secretion and ROS generation lie far beyond liver damage. In addition to the classic consequences of endotoxemia associated with liver cirrhosis that were described several decades ago, important research in the last ten years has shown that cytokines may also induce damage in remote organs such as brain, bone, muscle, heart, lung, gonads, peripheral nerve, and pancreas. These effects are even seen in alcoholics without significant liver disease. Therefore, alcoholism can be viewed as an inflammatory condition, a concept which opens the possibility of using new therapeutic weapons to treat some of the complications of this devastating and frequent disease. In this review we examine some of the most outstanding consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver.Excessive ethanol consumption affects virtually any organ, both by indirect and direct mechanisms. Considerable research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic manifestations of alcoholism. These cytokines derive primarily from activated Kupffer cells exposed to Gram-negative intestinal bacteria, which reach the liver in supra-physiological amounts due to ethanol-mediated increased gut permeability. Reactive oxygen species (ROS) that enhance the inflammatory response are generated both by activation of Kupffer cells and by the direct metabolic effects of ethanol. The effects of this increased cytokine secretion and ROS generation lie far beyond liver damage. In addition to the classic consequences of endotoxemia associated with liver cirrhosis that were described several decades ago, important research in the last ten years has shown that cytokines may also induce damage in remote organs such as brain, bone, muscle, heart, lung, gonads, peripheral nerve, and pancreas. These effects are even seen in alcoholics without significant liver disease. Therefore, alcoholism can be viewed as an inflammatory condition, a concept which opens the possibility of using new therapeutic weapons to treat some of the complications of this devastating and frequent disease. In this review we examine some of the most outstanding consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver. Excessive ethanol consumption affects virtually any organ, both by indirect and direct mechanisms. Considerable research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic manifestations of alcoholism. These cytokines derive primarily from activated Kupffer cells exposed to Gram-negative intestinal bacteria, which reach the liver in supra-physiological amounts due to ethanol-mediated increased gut permeability. Reactive oxygen species (ROS) that enhance the inflammatory response are generated both by activation of Kupffer cells and by the direct metabolic effects of ethanol. The effects of this increased cytokine secretion and ROS generation lie far beyond liver damage. In addition to the classic consequences of endotoxemia associated with liver cirrhosis that were described several decades ago, important research in the last ten years has shown that cytokines may also induce damage in remote organs such as brain, bone, muscle, heart, lung, gonads, peripheral nerve, and pancreas. These effects are even seen in alcoholics without significant liver disease. Therefore, alcoholism can be viewed as an inflammatory condition, a concept which opens the possibility of using new therapeutic weapons to treat some of the complications of this devastating and frequent disease. In this review we examine some of the most outstanding consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver. |
| Author | Fernández-Rodríguez, Camino María González-Reimers, Emilio Quintero-Platt, Geraldine Martín-González, María Candelaria Santolaria-Fernández, Francisco |
| Author_xml | – sequence: 1 givenname: Emilio surname: González-Reimers fullname: González-Reimers, Emilio organization: Emilio González-Reimers, Francisco Santolaria-Fernández, María Candelaria Martín-González, Camino María Fernández-Rodríguez, Geraldine Quintero-Platt, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, 38320 Canary Islands, Spain – sequence: 2 givenname: Francisco surname: Santolaria-Fernández fullname: Santolaria-Fernández, Francisco organization: Emilio González-Reimers, Francisco Santolaria-Fernández, María Candelaria Martín-González, Camino María Fernández-Rodríguez, Geraldine Quintero-Platt, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, 38320 Canary Islands, Spain – sequence: 3 givenname: María Candelaria surname: Martín-González fullname: Martín-González, María Candelaria organization: Emilio González-Reimers, Francisco Santolaria-Fernández, María Candelaria Martín-González, Camino María Fernández-Rodríguez, Geraldine Quintero-Platt, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, 38320 Canary Islands, Spain – sequence: 4 givenname: Camino María surname: Fernández-Rodríguez fullname: Fernández-Rodríguez, Camino María organization: Emilio González-Reimers, Francisco Santolaria-Fernández, María Candelaria Martín-González, Camino María Fernández-Rodríguez, Geraldine Quintero-Platt, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, 38320 Canary Islands, Spain – sequence: 5 givenname: Geraldine surname: Quintero-Platt fullname: Quintero-Platt, Geraldine organization: Emilio González-Reimers, Francisco Santolaria-Fernández, María Candelaria Martín-González, Camino María Fernández-Rodríguez, Geraldine Quintero-Platt, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, 38320 Canary Islands, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25356029$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNj8tOwzAURC0Eog_4ADYoSzYJ19eO47CrKl5SJTawjtxrB1zFcYlTUP-eShSJ1cziaHRmxk772DvGrjgUopL69nvzXnwhFF5CwaVScMKmiLzOUUs4_dcnbJbSBgCFKPGcTbAUpQKspwwWHcWP2PkU7jKTpX0aXfCUbYfo-7YzIZgxDvuMYm_96GN_wc5a0yV3ecw5e3u4f10-5auXx-flYpWTlGLMHXBOqkXpjLRKWKup1m1NtgUijVY70NIcHNpyDaomV3FDBsBKcrbiCufs5nf3YPK5c2lsgk_kus70Lu5Sw5WoSiUk6gN6fUR36-Bssx18MMO--XuJPxz1Vx0 |
| CitedBy_id | crossref_primary_10_4049_jimmunol_1600406 crossref_primary_10_1007_s11064_017_2218_8 crossref_primary_10_3390_antiox13010020 crossref_primary_10_1080_14656566_2018_1561870 crossref_primary_10_1053_j_gastro_2016_02_035 crossref_primary_10_1017_S0954422416000068 crossref_primary_10_3390_nu12020572 crossref_primary_10_1371_journal_pone_0178689 crossref_primary_10_3390_ijms17101651 crossref_primary_10_1038_s41467_019_08732_x crossref_primary_10_1080_13685538_2018_1477932 crossref_primary_10_1155_2019_6430486 crossref_primary_10_1007_s11010_020_03828_1 crossref_primary_10_1371_journal_pone_0209291 crossref_primary_10_1097_HEP_0000000000000303 crossref_primary_10_1002_ijc_31555 crossref_primary_10_3390_nu12082420 crossref_primary_10_3390_ijms24010347 crossref_primary_10_1242_jeb_128207 crossref_primary_10_15829_1560_4071_2019_11_164_172 crossref_primary_10_3390_brainsci7100131 crossref_primary_10_1111_jch_14571 crossref_primary_10_3389_fnins_2021_650785 crossref_primary_10_1111_pde_12881 crossref_primary_10_1007_s12012_022_09728_8 crossref_primary_10_1016_j_pnpbp_2018_03_006 crossref_primary_10_1016_j_bone_2024_117378 crossref_primary_10_1016_j_ntt_2016_06_001 crossref_primary_10_1177_17562848231202133 crossref_primary_10_3390_genes7090060 crossref_primary_10_1016_j_drugalcdep_2023_109886 crossref_primary_10_1016_j_jstrokecerebrovasdis_2019_104395 crossref_primary_10_1038_s41598_021_95131_2 crossref_primary_10_1097_MD_0000000000008041 crossref_primary_10_3390_nu10050654 crossref_primary_10_3390_ma13030695 crossref_primary_10_3892_etm_2020_8410 crossref_primary_10_1016_j_intimp_2024_113550 crossref_primary_10_1016_j_pnpbp_2018_04_015 crossref_primary_10_5435_JAAOSGlobal_D_20_00159 crossref_primary_10_1080_0886022X_2025_2487211 crossref_primary_10_3390_ph11010002 crossref_primary_10_1016_j_mehy_2024_111497 crossref_primary_10_1007_s12011_019_01887_0 crossref_primary_10_21303_2504_5679_2020_001177 crossref_primary_10_1134_S2079057018040021 crossref_primary_10_1007_s43032_024_01783_6 crossref_primary_10_1016_j_brainres_2020_146851 crossref_primary_10_1016_j_jbi_2022_104086 crossref_primary_10_1515_tjb_2024_0128 crossref_primary_10_1007_s10517_022_05511_5 crossref_primary_10_3390_ijms24021183 crossref_primary_10_1111_acer_14920 crossref_primary_10_1111_acer_13796 crossref_primary_10_1371_journal_pone_0147822 crossref_primary_10_3390_ijms24032981 crossref_primary_10_1038_nrcardio_2015_91 crossref_primary_10_1093_ajcn_nqy074 crossref_primary_10_1186_s13054_016_1458_3 crossref_primary_10_3390_antiox11071374 crossref_primary_10_1016_j_jpsychires_2022_12_043 crossref_primary_10_1080_15592294_2016_1179411 crossref_primary_10_1017_dmp_2020_452 crossref_primary_10_1155_2017_2712751 crossref_primary_10_1134_S0362119716020171 crossref_primary_10_3390_molecules20059183 crossref_primary_10_1016_j_jhsg_2025_100768 crossref_primary_10_1007_s00580_025_03647_0 crossref_primary_10_1093_alcalc_agae055 crossref_primary_10_1016_j_jad_2018_04_014 crossref_primary_10_1016_j_exger_2023_112132 crossref_primary_10_1002_alr_22289 crossref_primary_10_1038_s41598_025_97593_0 crossref_primary_10_1111_acer_12652 crossref_primary_10_1016_j_alcohol_2019_03_005 crossref_primary_10_14260_jemds_2016_516 crossref_primary_10_3390_biom5021099 crossref_primary_10_1111_jch_14669 crossref_primary_10_2478_aiht_2021_72_3432 crossref_primary_10_1007_s00198_020_05509_7 crossref_primary_10_1089_jmf_2017_4177 crossref_primary_10_3390_ijms17040472 crossref_primary_10_1002_jbt_22253 crossref_primary_10_3390_ijms24129976 crossref_primary_10_1016_j_alcohol_2024_12_003 crossref_primary_10_1016_j_clnu_2017_10_008 crossref_primary_10_1002_jemt_23642 crossref_primary_10_1016_j_tox_2015_06_006 crossref_primary_10_12677_OJNS_2023_112017 crossref_primary_10_5604_16652681_1226956 crossref_primary_10_3390_nu17050802 crossref_primary_10_1586_1744666X_2015_1081564 crossref_primary_10_1038_s41598_020_80637_y crossref_primary_10_1038_s41598_018_29041_1 crossref_primary_10_1016_j_dld_2023_05_022 crossref_primary_10_1093_alcalc_agaa034 crossref_primary_10_1016_j_jchemneu_2023_102310 crossref_primary_10_3390_healthcare10071341 crossref_primary_10_1016_j_bonr_2025_101836 crossref_primary_10_1038_s41380_020_00920_2 crossref_primary_10_1002_hep_29338 crossref_primary_10_1016_j_mehy_2016_11_009 crossref_primary_10_3748_wjg_v24_i26_2785 crossref_primary_10_3390_ijms22147299 crossref_primary_10_1111_fcp_12433 crossref_primary_10_3389_fimmu_2016_00538 crossref_primary_10_1097_HC9_0000000000000771 crossref_primary_10_1016_j_drugalcdep_2018_09_024 crossref_primary_10_3390_md13021051 crossref_primary_10_1016_j_alcohol_2018_08_009 crossref_primary_10_1016_j_bbrc_2015_06_011 crossref_primary_10_1371_journal_pcbi_1009800 crossref_primary_10_1002_jcb_25389 crossref_primary_10_1016_j_cmi_2020_01_010 crossref_primary_10_1016_j_bbr_2023_114352 crossref_primary_10_1016_j_mehy_2022_110799 crossref_primary_10_3389_fimmu_2023_1093584 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.3748/wjg.v20.i40.14660 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| EISSN | 2219-2840 |
| ExternalDocumentID | 25356029 |
| Genre | Journal Article Review |
| GroupedDBID | --- 123 29R 2WC 36B 53G 5VR 8WL AAKDD ACGFO AENEX AFUIB ALMA_UNASSIGNED_HOLDINGS CCEZO CGR CHBEP CIEJG CS3 CUY CVF CW9 DIK DU5 E3Z EBS ECM EIF EJD F5P FRP GX1 HYE NPM OK1 P2P RNS RPM TR2 XSB 7X8 |
| ID | FETCH-LOGICAL-c443t-e011c6f24ea4d63dd8c98f9cdf0cc82d8e084a602f5b069ce71aca00d4ced7162 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 136 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000343881800013&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2219-2840 |
| IngestDate | Fri Jul 11 11:04:46 EDT 2025 Mon Jul 21 05:55:24 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 40 |
| Keywords | Brain Cytokines Oxidative damage Alcoholism Chronic pancreatitis Lung Atherosclerosis Sepsis Muscle Bone Alcoholic liver disease |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c443t-e011c6f24ea4d63dd8c98f9cdf0cc82d8e084a602f5b069ce71aca00d4ced7162 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.wjgnet.com/1007-9327/full/v20/i40/14660.htm |
| PMID | 25356029 |
| PQID | 1637563428 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1637563428 pubmed_primary_25356029 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-10-28 |
| PublicationDateYYYYMMDD | 2014-10-28 |
| PublicationDate_xml | – month: 10 year: 2014 text: 2014-10-28 day: 28 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | World journal of gastroenterology : WJG |
| PublicationTitleAlternate | World J Gastroenterol |
| PublicationYear | 2014 |
| References | 24256560 - Alcohol Clin Exp Res. 2014 Mar;38(3):672-82 21599718 - Alcohol Clin Exp Res. 2011 Sep;35(9):1678-85 15869836 - Food Chem Toxicol. 2005 Sep;43(9):1333-43 16385177 - Alcohol Clin Exp Res. 2005 Dec;29(12):2077-90 11018077 - J Clin Invest. 2000 Oct;106(7):887-95 23733506 - Alcohol Alcohol. 2013 Jul-Aug;48(4):495-504 21357267 - J Immunol. 2011 Apr 1;186(7):4306-13 18348728 - J Neuroinflammation. 2008;5:10 16628628 - Hepatology. 2006 May;43(5):989-1000 24030397 - Circulation. 2013 Sep 10;128(11 Suppl 1):S136-43 12193460 - Circ Res. 2002 Aug 23;91(4):281-91 9339743 - J Appl Toxicol. 1997 Sep-Oct;17(5):307-11 21343206 - BMJ. 2011;342:d636 15778906 - J Neurol. 2005 Jun;252(6):704-11 17919500 - Gastroenterology. 2007 Oct;133(4):1293-303 17220368 - Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1193-201 18419766 - J Neurochem. 2008 Jul;106(2):625-39 15777248 - Curr Pharm Des. 2005;11(8):973-84 7813281 - Chest. 1995 Jan;107(1):214-7 14657449 - Stroke. 2004 Jan;35(1):16-21 12717397 - Hepatology. 2003 May;37(5):1154-64 7618989 - Arch Intern Med. 1995 Aug 7-21;155(15):1649-54 15316086 - J Pharmacol Exp Ther. 2004 Dec;311(3):921-8 12626543 - J Immunol. 2003 Mar 15;170(6):2923-31 21130596 - Alcohol. 2011 Jun;45(4):381-91 22320924 - J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:89-93 23547562 - Respir Res. 2013;14:39 16272348 - J Immunol. 2005 Nov 15;175(10):6893-9 3948365 - Circulation. 1986 Apr;73(4):628-36 23646229 - World J Hepatol. 2013 Feb 27;5(2):46-55 21636604 - Alcohol Alcohol. 2011 Sep-Oct;46(5):529-33 8651446 - Alcohol Clin Exp Res. 1996 Feb;20(1):156-63 12586277 - Am J Cardiol. 2003 Feb 15;91(4):491-4 16680157 - Mod Pathol. 2006 Aug;19(8):1019-26 17507544 - Am J Respir Crit Care Med. 2007 Aug 1;176(3):270-6 23811249 - Clin Gastroenterol Hepatol. 2014 Apr;12(4):555-64; quiz e31-2 22441020 - Autophagy. 2012 Apr;8(4):593-608 22065426 - Infection. 2011 Dec;39(6):519-26 22173040 - Am J Med Sci. 2012 Mar;343(3):244-7 8523623 - JPEN J Parenter Enteral Nutr. 1995 Jul-Aug;19(4):258-65 22955728 - Circ Res. 2012 Sep 28;111(8):1065-8 19825859 - Toxicol Ind Health. 2009 Sep;25(8):525-38 15105163 - Am J Respir Crit Care Med. 2004 Jul 15;170(2):188-94 21624786 - Alcohol. 2011 Aug;45(5):507-14 22240163 - J Neuroinflammation. 2012;9:5 22158662 - Int J Epidemiol. 2011 Dec;40(6):1519-29 2339855 - Ann Intern Med. 1990 Jun 15;112(12):917-20 7737723 - Hypertension. 1995 May;25(5):1106-10 23509726 - Biomed Res Int. 2013;2013:470217 24146816 - PLoS One. 2013;8(10):e76057 11784353 - Eur J Neurol. 2001 Nov;8(6):677-87 9734366 - Mol Cell. 1998 Aug;2(2):275-81 16888021 - J Immunol. 2006 Aug 15;177(4):2592-600 19575462 - Hepatology. 2009 Aug;50(2):638-44 9185748 - Hepatology. 1997 Jun;25(6):1334-7 7083522 - Circulation. 1982 Jul;66(1):60-6 20201930 - Alcohol Clin Exp Res. 2010 May;34(5):876-85 17895323 - J Clin Endocrinol Metab. 2007 Dec;92(12):4514-21 20404723 - Curr Opin Anaesthesiol. 2010 Jun;23(3):384-90 12500110 - Alcohol Clin Exp Res. 2002 Dec;26(12):1858-62 19535494 - Alcohol Alcohol. 2009 Sep-Oct;44(5):468-75 23689109 - Ann Nutr Metab. 2013;62 Suppl 1:8-17 3711540 - J Am Coll Cardiol. 1986 Jul;8(1 Suppl A):22A-32A 24130229 - Thorax. 2013 Nov;68(11):1057-65 20190231 - Alcohol Alcohol. 2010 May-Jun;45(3):223-30 21098503 - Alcohol Alcohol. 2011 Jan-Feb;46(1):26-32 8510296 - JAMA. 1993 Jul 7;270(1):51-6 15638783 - Curr Vasc Pharmacol. 2005 Jan;3(1):63-8 10564684 - N Engl J Med. 1999 Nov 18;341(21):1557-64 14578353 - J Biol Chem. 2004 Jan 9;279(2):1415-21 21757824 - Circ J. 2011;75(9):2269-79 23849887 - J Cardiol. 2013 Dec;62(6):374-8 23892124 - Toxicol Lett. 2013 Oct 24;222(2):171-9 12437579 - J Neurochem. 2002 Dec;83(5):1087-93 22041278 - J Mol Cell Cardiol. 2012 Jan;52(1):93-104 14615545 - Science. 2003 Dec 5;302(5651):1760-5 21846370 - AIDS Res Ther. 2011 Aug 16;8:30 22364379 - BMC Cardiovasc Disord. 2012;12:10 21098090 - J Pharmacol Exp Ther. 2011 Mar;336(3):734-42 9194923 - Alcohol Clin Exp Res. 1997 Jun;21(4):672-6 11788365 - Am J Physiol Endocrinol Metab. 2002 Feb;282(2):E336-47 20807717 - Alcohol Alcohol. 2010 Sep-Oct;45(5):427-30 11447082 - Circulation. 2001 Jul 10;104(2):174-80 19585655 - Hepatology. 2009 Sep;50(3):957-69 1738215 - JPEN J Parenter Enteral Nutr. 1992 Jan-Feb;16(1):25-31 24089530 - J Biol Chem. 2013 Nov 8;288(45):32517-27 19030200 - World J Gastroenterol. 2008 Nov 14;14(42):6488-95 17764883 - Alcohol. 2007 Aug;41(5):293-307 16628232 - Cell Death Differ. 2007 Jan;14(1):171-82 854058 - N Engl J Med. 1977 May 26;296(21):1194-200 21421450 - Eur Cytokine Netw. 2011 Mar;22(1):1-4 18597620 - J Interferon Cytokine Res. 2008 Jul;28(7):413-22 23939347 - JAMA Intern Med. 2013 Sep 23;173(17):1612-8 23016132 - Nutrients. 2012 Aug;4(8):1058-75 23346021 - ScientificWorldJournal. 2012;2012:740308 14629892 - J Nutr Biochem. 2003 Nov;14(11):616-25 21463333 - Alcohol Clin Exp Res. 2011 Jul;35(7):1220-9 21908154 - Alcohol. 2012 Mar;46(2):133-8 17913441 - Alcohol. 2007 Nov;41(7):511-5 24140864 - Free Radic Biol Med. 2013 Dec;65:1427-34 18940959 - Alcohol Alcohol. 2009 Mar-Apr;44(2):115-27 17261733 - Stroke. 2007 Feb;38(2 Suppl):759-62 15469574 - Crit Care. 2004 Oct;8(5):R312-21 20238396 - World J Gastroenterol. 2010 Mar 21;16(11):1304-13 24020403 - Int J Exp Pathol. 2013 Oct;94(5):312-9 9267524 - Alcohol Clin Exp Res. 1997 Aug;21(5):773-8 20510870 - Immunity. 2010 May 28;32(5):593-604 7817807 - J Bone Miner Res. 1994 Oct;9(10):1607-12 16573591 - Alcohol Clin Exp Res. 2006 Apr;30(4):720-30 23717394 - PLoS One. 2013;8(5):e62792 21988193 - Br J Clin Pharmacol. 2012 Mar;73(3):348-62 20923804 - Chest. 2010 Oct;138(4):994-1003 16579978 - Cardiovasc Res. 2006 Jun 1;70(3):589-99 11904657 - Intensive Care Med. 2002 Mar;28(3):285-92 23805851 - Am J Respir Crit Care Med. 2013 Sep 15;188(6):716-23 20562495 - Circ J. 2010 Aug;74(8):1547-56 22524187 - Annu Rev Nutr. 2012 Aug 21;32:343-68 19147798 - Alcohol Alcohol. 2009 Mar-Apr;44(2):136-40 17680644 - Hepatology. 2007 Sep;46(3):831-40 24187595 - Transl Stroke Res. 2013 Oct;4(5):546-53 16930216 - Alcohol Clin Exp Res. 2006 Sep;30(9):1538-44 17220370 - Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L813-23 8891438 - Cytokine. 1996 Jul;8(7):567-77 12233981 - Exp Clin Psychopharmacol. 2002 Aug;10(3):193-212 10069572 - Alcohol Clin Exp Res. 1999 Feb;23(2):381-5 24371146 - J Biol Chem. 2014 Feb 14;289(7):4095-105 17599958 - Clin Chem. 2007 Sep;53(9):1652-7 3393181 - N Engl J Med. 1988 Aug 4;319(5):267-73 22349682 - J Alzheimers Dis. 2012;29(4):773-82 19559159 - Am J Med. 2009 Jul;122(7):605-13 20201932 - Alcohol Clin Exp Res. 2010 May;34(5):777-89 21854333 - Neuropsychol Rehabil. 2003 Jan-Mar;13(1-2):165-88 2913506 - N Engl J Med. 1989 Feb 16;320(7):409-15 14691909 - Hum Pathol. 2003 Dec;34(12):1247-52 |
| References_xml | – reference: 17680644 - Hepatology. 2007 Sep;46(3):831-40 – reference: 24371146 - J Biol Chem. 2014 Feb 14;289(7):4095-105 – reference: 11904657 - Intensive Care Med. 2002 Mar;28(3):285-92 – reference: 20238396 - World J Gastroenterol. 2010 Mar 21;16(11):1304-13 – reference: 21846370 - AIDS Res Ther. 2011 Aug 16;8:30 – reference: 16573591 - Alcohol Clin Exp Res. 2006 Apr;30(4):720-30 – reference: 22065426 - Infection. 2011 Dec;39(6):519-26 – reference: 2339855 - Ann Intern Med. 1990 Jun 15;112(12):917-20 – reference: 8523623 - JPEN J Parenter Enteral Nutr. 1995 Jul-Aug;19(4):258-65 – reference: 16628232 - Cell Death Differ. 2007 Jan;14(1):171-82 – reference: 23646229 - World J Hepatol. 2013 Feb 27;5(2):46-55 – reference: 16888021 - J Immunol. 2006 Aug 15;177(4):2592-600 – reference: 9185748 - Hepatology. 1997 Jun;25(6):1334-7 – reference: 3948365 - Circulation. 1986 Apr;73(4):628-36 – reference: 19147798 - Alcohol Alcohol. 2009 Mar-Apr;44(2):136-40 – reference: 20510870 - Immunity. 2010 May 28;32(5):593-604 – reference: 12233981 - Exp Clin Psychopharmacol. 2002 Aug;10(3):193-212 – reference: 16628628 - Hepatology. 2006 May;43(5):989-1000 – reference: 11447082 - Circulation. 2001 Jul 10;104(2):174-80 – reference: 24020403 - Int J Exp Pathol. 2013 Oct;94(5):312-9 – reference: 17507544 - Am J Respir Crit Care Med. 2007 Aug 1;176(3):270-6 – reference: 11784353 - Eur J Neurol. 2001 Nov;8(6):677-87 – reference: 16680157 - Mod Pathol. 2006 Aug;19(8):1019-26 – reference: 14629892 - J Nutr Biochem. 2003 Nov;14(11):616-25 – reference: 20201930 - Alcohol Clin Exp Res. 2010 May;34(5):876-85 – reference: 15778906 - J Neurol. 2005 Jun;252(6):704-11 – reference: 22364379 - BMC Cardiovasc Disord. 2012;12:10 – reference: 11018077 - J Clin Invest. 2000 Oct;106(7):887-95 – reference: 20807717 - Alcohol Alcohol. 2010 Sep-Oct;45(5):427-30 – reference: 23892124 - Toxicol Lett. 2013 Oct 24;222(2):171-9 – reference: 24030397 - Circulation. 2013 Sep 10;128(11 Suppl 1):S136-43 – reference: 19825859 - Toxicol Ind Health. 2009 Sep;25(8):525-38 – reference: 15777248 - Curr Pharm Des. 2005;11(8):973-84 – reference: 16579978 - Cardiovasc Res. 2006 Jun 1;70(3):589-99 – reference: 23717394 - PLoS One. 2013;8(5):e62792 – reference: 14578353 - J Biol Chem. 2004 Jan 9;279(2):1415-21 – reference: 21636604 - Alcohol Alcohol. 2011 Sep-Oct;46(5):529-33 – reference: 9734366 - Mol Cell. 1998 Aug;2(2):275-81 – reference: 21463333 - Alcohol Clin Exp Res. 2011 Jul;35(7):1220-9 – reference: 21421450 - Eur Cytokine Netw. 2011 Mar;22(1):1-4 – reference: 16930216 - Alcohol Clin Exp Res. 2006 Sep;30(9):1538-44 – reference: 17764883 - Alcohol. 2007 Aug;41(5):293-307 – reference: 12586277 - Am J Cardiol. 2003 Feb 15;91(4):491-4 – reference: 23733506 - Alcohol Alcohol. 2013 Jul-Aug;48(4):495-504 – reference: 17913441 - Alcohol. 2007 Nov;41(7):511-5 – reference: 24187595 - Transl Stroke Res. 2013 Oct;4(5):546-53 – reference: 15638783 - Curr Vasc Pharmacol. 2005 Jan;3(1):63-8 – reference: 22158662 - Int J Epidemiol. 2011 Dec;40(6):1519-29 – reference: 9267524 - Alcohol Clin Exp Res. 1997 Aug;21(5):773-8 – reference: 17919500 - Gastroenterology. 2007 Oct;133(4):1293-303 – reference: 22041278 - J Mol Cell Cardiol. 2012 Jan;52(1):93-104 – reference: 20404723 - Curr Opin Anaesthesiol. 2010 Jun;23(3):384-90 – reference: 21757824 - Circ J. 2011;75(9):2269-79 – reference: 20562495 - Circ J. 2010 Aug;74(8):1547-56 – reference: 8651446 - Alcohol Clin Exp Res. 1996 Feb;20(1):156-63 – reference: 22349682 - J Alzheimers Dis. 2012;29(4):773-82 – reference: 7813281 - Chest. 1995 Jan;107(1):214-7 – reference: 23509726 - Biomed Res Int. 2013;2013:470217 – reference: 12626543 - J Immunol. 2003 Mar 15;170(6):2923-31 – reference: 1738215 - JPEN J Parenter Enteral Nutr. 1992 Jan-Feb;16(1):25-31 – reference: 7083522 - Circulation. 1982 Jul;66(1):60-6 – reference: 22524187 - Annu Rev Nutr. 2012 Aug 21;32:343-68 – reference: 854058 - N Engl J Med. 1977 May 26;296(21):1194-200 – reference: 23805851 - Am J Respir Crit Care Med. 2013 Sep 15;188(6):716-23 – reference: 17895323 - J Clin Endocrinol Metab. 2007 Dec;92(12):4514-21 – reference: 23016132 - Nutrients. 2012 Aug;4(8):1058-75 – reference: 18419766 - J Neurochem. 2008 Jul;106(2):625-39 – reference: 18940959 - Alcohol Alcohol. 2009 Mar-Apr;44(2):115-27 – reference: 23689109 - Ann Nutr Metab. 2013;62 Suppl 1:8-17 – reference: 22173040 - Am J Med Sci. 2012 Mar;343(3):244-7 – reference: 21098503 - Alcohol Alcohol. 2011 Jan-Feb;46(1):26-32 – reference: 21599718 - Alcohol Clin Exp Res. 2011 Sep;35(9):1678-85 – reference: 8510296 - JAMA. 1993 Jul 7;270(1):51-6 – reference: 21908154 - Alcohol. 2012 Mar;46(2):133-8 – reference: 24089530 - J Biol Chem. 2013 Nov 8;288(45):32517-27 – reference: 19535494 - Alcohol Alcohol. 2009 Sep-Oct;44(5):468-75 – reference: 24130229 - Thorax. 2013 Nov;68(11):1057-65 – reference: 3393181 - N Engl J Med. 1988 Aug 4;319(5):267-73 – reference: 19575462 - Hepatology. 2009 Aug;50(2):638-44 – reference: 15105163 - Am J Respir Crit Care Med. 2004 Jul 15;170(2):188-94 – reference: 9339743 - J Appl Toxicol. 1997 Sep-Oct;17(5):307-11 – reference: 14615545 - Science. 2003 Dec 5;302(5651):1760-5 – reference: 7618989 - Arch Intern Med. 1995 Aug 7-21;155(15):1649-54 – reference: 12717397 - Hepatology. 2003 May;37(5):1154-64 – reference: 21357267 - J Immunol. 2011 Apr 1;186(7):4306-13 – reference: 14657449 - Stroke. 2004 Jan;35(1):16-21 – reference: 21854333 - Neuropsychol Rehabil. 2003 Jan-Mar;13(1-2):165-88 – reference: 22320924 - J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:89-93 – reference: 19585655 - Hepatology. 2009 Sep;50(3):957-69 – reference: 17261733 - Stroke. 2007 Feb;38(2 Suppl):759-62 – reference: 24146816 - PLoS One. 2013;8(10):e76057 – reference: 22240163 - J Neuroinflammation. 2012;9:5 – reference: 21130596 - Alcohol. 2011 Jun;45(4):381-91 – reference: 8891438 - Cytokine. 1996 Jul;8(7):567-77 – reference: 17599958 - Clin Chem. 2007 Sep;53(9):1652-7 – reference: 23346021 - ScientificWorldJournal. 2012;2012:740308 – reference: 21098090 - J Pharmacol Exp Ther. 2011 Mar;336(3):734-42 – reference: 21988193 - Br J Clin Pharmacol. 2012 Mar;73(3):348-62 – reference: 7817807 - J Bone Miner Res. 1994 Oct;9(10):1607-12 – reference: 19559159 - Am J Med. 2009 Jul;122(7):605-13 – reference: 21624786 - Alcohol. 2011 Aug;45(5):507-14 – reference: 23547562 - Respir Res. 2013;14:39 – reference: 20923804 - Chest. 2010 Oct;138(4):994-1003 – reference: 14691909 - Hum Pathol. 2003 Dec;34(12):1247-52 – reference: 22441020 - Autophagy. 2012 Apr;8(4):593-608 – reference: 12500110 - Alcohol Clin Exp Res. 2002 Dec;26(12):1858-62 – reference: 21343206 - BMJ. 2011;342:d636 – reference: 19030200 - World J Gastroenterol. 2008 Nov 14;14(42):6488-95 – reference: 18597620 - J Interferon Cytokine Res. 2008 Jul;28(7):413-22 – reference: 20190231 - Alcohol Alcohol. 2010 May-Jun;45(3):223-30 – reference: 15316086 - J Pharmacol Exp Ther. 2004 Dec;311(3):921-8 – reference: 15469574 - Crit Care. 2004 Oct;8(5):R312-21 – reference: 7737723 - Hypertension. 1995 May;25(5):1106-10 – reference: 17220368 - Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1193-201 – reference: 3711540 - J Am Coll Cardiol. 1986 Jul;8(1 Suppl A):22A-32A – reference: 17220370 - Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L813-23 – reference: 16385177 - Alcohol Clin Exp Res. 2005 Dec;29(12):2077-90 – reference: 12193460 - Circ Res. 2002 Aug 23;91(4):281-91 – reference: 15869836 - Food Chem Toxicol. 2005 Sep;43(9):1333-43 – reference: 23939347 - JAMA Intern Med. 2013 Sep 23;173(17):1612-8 – reference: 16272348 - J Immunol. 2005 Nov 15;175(10):6893-9 – reference: 20201932 - Alcohol Clin Exp Res. 2010 May;34(5):777-89 – reference: 24140864 - Free Radic Biol Med. 2013 Dec;65:1427-34 – reference: 24256560 - Alcohol Clin Exp Res. 2014 Mar;38(3):672-82 – reference: 18348728 - J Neuroinflammation. 2008;5:10 – reference: 22955728 - Circ Res. 2012 Sep 28;111(8):1065-8 – reference: 2913506 - N Engl J Med. 1989 Feb 16;320(7):409-15 – reference: 11788365 - Am J Physiol Endocrinol Metab. 2002 Feb;282(2):E336-47 – reference: 10564684 - N Engl J Med. 1999 Nov 18;341(21):1557-64 – reference: 12437579 - J Neurochem. 2002 Dec;83(5):1087-93 – reference: 10069572 - Alcohol Clin Exp Res. 1999 Feb;23(2):381-5 – reference: 23849887 - J Cardiol. 2013 Dec;62(6):374-8 – reference: 23811249 - Clin Gastroenterol Hepatol. 2014 Apr;12(4):555-64; quiz e31-2 – reference: 9194923 - Alcohol Clin Exp Res. 1997 Jun;21(4):672-6 |
| SSID | ssj0023352 |
| Score | 2.4941285 |
| SecondaryResourceType | review_article |
| Snippet | Excessive ethanol consumption affects virtually any organ, both by indirect and direct mechanisms. Considerable research in the last two decades has widened... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 14660 |
| SubjectTerms | Alcohol Drinking - adverse effects Alcohol Drinking - metabolism Alcohol Drinking - mortality Alcoholism - diagnosis Alcoholism - etiology Alcoholism - metabolism Alcoholism - mortality Animals Cytokines - metabolism Ethanol - adverse effects Humans Inflammation - diagnosis Inflammation - etiology Inflammation - metabolism Inflammation - mortality Inflammation Mediators - metabolism Liver - drug effects Liver - metabolism Liver - pathology Liver Diseases, Alcoholic - diagnosis Liver Diseases, Alcoholic - etiology Liver Diseases, Alcoholic - metabolism Liver Diseases, Alcoholic - mortality Oxidative Stress - drug effects Prognosis Reactive Oxygen Species - metabolism Risk Assessment Risk Factors |
| Title | Alcoholism: a systemic proinflammatory condition |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/25356029 https://www.proquest.com/docview/1637563428 |
| Volume | 20 |
| WOSCitedRecordID | wos000343881800013&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV05T8MwFLaAMrBwiKtcChKrW9dHbLOgClExQNUBpG6R4wMFqQeklL_Pc5LCwoDEki1x9PK958_-nO8hdMUo48I6iwG7sEARxuBcSYeZYyrPezoIV1nmP8jhUI3HetRsuJXNscpVTawKtZvZuEfeBd4gRcqALd_M33DsGhXV1aaFxjpqMaAyMTHl-FtFoPF_othcDrISQxluVM1ouNL9fH3pLCnpFJzEYtE4VP7KMKuZZrDz33fcRdsNx0z6NSj20Jqf7iPSr5vhFuXkOjFJ7eBc2ASGAJABLiaV3p7A-thVx7gO0PPg7un2HjftErDlnC2wh1S1aaDcG-5S5pyyWgVtXSDWKuqUJ4qblNAgcpJq62XPWEOI49a7aCR1iDams6k_RolQRgbBRK5IiD6hWnjCBNPKpLKnJWujy1UAMoBj1BjM1M8-yuwnBG10VEcxm9e-GRmFJ8Lw-uQPd5-iLaAmPM4SVJ2hVoBk9Odo0y4XRfl-UX1nuA5Hj18-erIC |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Alcoholism%3A+a+systemic+proinflammatory+condition&rft.jtitle=World+journal+of+gastroenterology+%3A+WJG&rft.au=Gonz%C3%A1lez-Reimers%2C+Emilio&rft.au=Santolaria-Fern%C3%A1ndez%2C+Francisco&rft.au=Mart%C3%ADn-Gonz%C3%A1lez%2C+Mar%C3%ADa+Candelaria&rft.au=Fern%C3%A1ndez-Rodr%C3%ADguez%2C+Camino+Mar%C3%ADa&rft.date=2014-10-28&rft.issn=2219-2840&rft.eissn=2219-2840&rft.volume=20&rft.issue=40&rft.spage=14660&rft_id=info:doi/10.3748%2Fwjg.v20.i40.14660&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2219-2840&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2219-2840&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2219-2840&client=summon |