Matrix metalloproteinases in exercise and obesity

Matrix metalloproteinases (MMPs) are zinc- and calcium-dependent endoproteinases that have the ability to break down extracellular matrix. The large range of MMPs' functions widens their spectrum of potential role as activators or inhibitors in tissue remodeling, cardiovascular diseases, and ob...

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Veröffentlicht in:Vascular health and risk management Jg. 12; S. 287 - 295
Hauptverfasser: Koh, Yunsuk, Jaoude, Jonathan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New Zealand Dove Medical Press Limited 01.01.2016
Taylor & Francis Ltd
Dove Medical Press
Schlagworte:
Animals
Atherosclerosis
Blood pressure
Body composition
Care and treatment
Carotid arteries
Collagenases - metabolism
Coronary vessels
Disease
Dosage and administration
Enzyme Activation
Exercise
Exercise - physiology
Fitness training programs
Health aspects
Humans
Kinases
Matrix Metalloproteinase 1 - metabolism
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9 - metabolism
Matrix metalloproteinase inhibitors
Matrix Metalloproteinases, Secreted - metabolism
Musculoskeletal system
Obesity
Obesity - enzymology
Obesity - physiopathology
Patient outcomes
Phosphorylation
Review
Strength training
Tissue Inhibitor of Metalloproteinases - metabolism
Veins & arteries
Weight control
cardiovascular disease
collagenases
gelatinases
TIMP
ISSN:1178-2048, 1176-6344, 1178-2048
Online-Zugang:Volltext
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Zusammenfassung:Matrix metalloproteinases (MMPs) are zinc- and calcium-dependent endoproteinases that have the ability to break down extracellular matrix. The large range of MMPs' functions widens their spectrum of potential role as activators or inhibitors in tissue remodeling, cardiovascular diseases, and obesity. In particular, MMP-1, -2, and -9 may be associated with exercise and obesity. Thus, the current study reviewed the effects of different types of exercise (resistance and aerobic) on MMP-1, -2, and -9. Previous studies report that the response of MMP-2 and -9 to resistance exercise is dependent upon the length of exercise training, since long-term resistance exercise training increased both MMP-2 and -9, whereas acute bout of resistance exercise decreased these MMPs. Aerobic exercise produces an inconsistent result on MMPs, although some studies showed a decrease in MMP-1. Obesity is related to a relatively lower level of MMP-9, indicating that an exercise-induced increase in MMP-9 may positively influence obesity. A comprehensive understanding of the relationship between exercise, obesity, and MMPs does not exist yet. Future studies examining the acute and chronic responses of these MMPs using different subject models may provide a better understanding of the molecular mechanisms that are associated with exercise, obesity, and cardiovascular disease.
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ISSN:1178-2048
1176-6344
1178-2048
DOI:10.2147/VHRM.S103877