Proteinuria as a significant predictive factor for the progression of carotid artery atherosclerosis in non-albuminuric type 2 diabetes
•A high urine protein-to-creatinine ratio may be a useful and early predictive marker for the progression of carotid artery atherosclerosis , even in patients with type 2 diabetes and without albuminuria.•A high urine protein-to-creatinine ratio may be an earlier indicator of DKD development than al...
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| Veröffentlicht in: | Diabetes research and clinical practice Jg. 181; S. 109082 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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Elsevier B.V
01.11.2021
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| ISSN: | 0168-8227, 1872-8227, 1872-8227 |
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| Abstract | •A high urine protein-to-creatinine ratio may be a useful and early predictive marker for the progression of carotid artery atherosclerosis , even in patients with type 2 diabetes and without albuminuria.•A high urine protein-to-creatinine ratio may be an earlier indicator of DKD development than albuminuria, suggesting renal tubulopathy.•A retrospective study included 927 participants with type 2 diabetes and without albuminuria.
This study aimed to evaluate the clinical significance of urine protein to creatinine ratio (uPCR) in relation to the cardiovascular risk associated with carotid artery intima-media thickness (cIMT) progression in subjects with type 2 diabetes (T2D) and normoalbuminuria.
In this retrospective longitudinal study on T2D, we recruited 927 participants with normoalbuminuria (urine albumin to creatinine ratio [uACR] < 30 mg/g) whose cIMT was measured at baseline and after at least 1 year, and whose initial uPCR and uACR data were available.
Higher initial uPCR was positively correlated with a greater increment in maximal cIMT (β = 0.074, p = 0.028), and this correlation was significant even after adjusting for multiple confounding factors (β = 0.074, p = 0.046). High baseline uPCR was an independent predictive factor for the increased risk of maximal cIMT progression in a simple logistic regression model (OR, 1.41; 95% CI, [1.08–1.86]; p = 0.013). Even after adjusting for several confounding variables, higher uPCR was significantly associated with a higher risk of cIMT progression (OR, 1.48; 95% CI, [1.08–2.03]; p = 0.014).
These results suggest that high uPCR may be a useful predictive marker for the progression of carotid artery atherosclerosis, even in subjects with T2D and without albuminuria. |
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| AbstractList | This study aimed to evaluate the clinical significance of urine protein to creatinine ratio (uPCR) in relation to the cardiovascular risk associated with carotid artery intima-media thickness (cIMT) progression in subjects with type 2 diabetes (T2D) and normoalbuminuria.AIMSThis study aimed to evaluate the clinical significance of urine protein to creatinine ratio (uPCR) in relation to the cardiovascular risk associated with carotid artery intima-media thickness (cIMT) progression in subjects with type 2 diabetes (T2D) and normoalbuminuria.In this retrospective longitudinal study on T2D, we recruited 927 participants with normoalbuminuria (urine albumin to creatinine ratio [uACR] < 30 mg/g) whose cIMT was measured at baseline and after at least 1 year, and whose initial uPCR and uACR data were available.METHODSIn this retrospective longitudinal study on T2D, we recruited 927 participants with normoalbuminuria (urine albumin to creatinine ratio [uACR] < 30 mg/g) whose cIMT was measured at baseline and after at least 1 year, and whose initial uPCR and uACR data were available.Higher initial uPCR was positively correlated with a greater increment in maximal cIMT (β = 0.074, p = 0.028), and this correlation was significant even after adjusting for multiple confounding factors (β = 0.074, p = 0.046). High baseline uPCR was an independent predictive factor for the increased risk of maximal cIMT progression in a simple logistic regression model (OR, 1.41; 95% CI, [1.08-1.86]; p = 0.013). Even after adjusting for several confounding variables, higher uPCR was significantly associated with a higher risk of cIMT progression (OR, 1.48; 95% CI, [1.08-2.03]; p = 0.014).RESULTSHigher initial uPCR was positively correlated with a greater increment in maximal cIMT (β = 0.074, p = 0.028), and this correlation was significant even after adjusting for multiple confounding factors (β = 0.074, p = 0.046). High baseline uPCR was an independent predictive factor for the increased risk of maximal cIMT progression in a simple logistic regression model (OR, 1.41; 95% CI, [1.08-1.86]; p = 0.013). Even after adjusting for several confounding variables, higher uPCR was significantly associated with a higher risk of cIMT progression (OR, 1.48; 95% CI, [1.08-2.03]; p = 0.014).These results suggest that high uPCR may be a useful predictive marker for the progression of carotid artery atherosclerosis, even in subjects with T2D and without albuminuria.CONCLUSIONSThese results suggest that high uPCR may be a useful predictive marker for the progression of carotid artery atherosclerosis, even in subjects with T2D and without albuminuria. •A high urine protein-to-creatinine ratio may be a useful and early predictive marker for the progression of carotid artery atherosclerosis , even in patients with type 2 diabetes and without albuminuria.•A high urine protein-to-creatinine ratio may be an earlier indicator of DKD development than albuminuria, suggesting renal tubulopathy.•A retrospective study included 927 participants with type 2 diabetes and without albuminuria. This study aimed to evaluate the clinical significance of urine protein to creatinine ratio (uPCR) in relation to the cardiovascular risk associated with carotid artery intima-media thickness (cIMT) progression in subjects with type 2 diabetes (T2D) and normoalbuminuria. In this retrospective longitudinal study on T2D, we recruited 927 participants with normoalbuminuria (urine albumin to creatinine ratio [uACR] < 30 mg/g) whose cIMT was measured at baseline and after at least 1 year, and whose initial uPCR and uACR data were available. Higher initial uPCR was positively correlated with a greater increment in maximal cIMT (β = 0.074, p = 0.028), and this correlation was significant even after adjusting for multiple confounding factors (β = 0.074, p = 0.046). High baseline uPCR was an independent predictive factor for the increased risk of maximal cIMT progression in a simple logistic regression model (OR, 1.41; 95% CI, [1.08–1.86]; p = 0.013). Even after adjusting for several confounding variables, higher uPCR was significantly associated with a higher risk of cIMT progression (OR, 1.48; 95% CI, [1.08–2.03]; p = 0.014). These results suggest that high uPCR may be a useful predictive marker for the progression of carotid artery atherosclerosis, even in subjects with T2D and without albuminuria. |
| ArticleNumber | 109082 |
| Author | Lee, Byung-Wan Lee, Minyoung Lee, Yong-ho Kim, Young-eun Kang, Eun Seok Cha, Bong-soo |
| Author_xml | – sequence: 1 givenname: Young-eun surname: Kim fullname: Kim, Young-eun – sequence: 2 givenname: Minyoung surname: Lee fullname: Lee, Minyoung – sequence: 3 givenname: Yong-ho surname: Lee fullname: Lee, Yong-ho – sequence: 4 givenname: Eun Seok surname: Kang fullname: Kang, Eun Seok – sequence: 5 givenname: Bong-soo surname: Cha fullname: Cha, Bong-soo – sequence: 6 givenname: Byung-Wan surname: Lee fullname: Lee, Byung-Wan email: BWANLEE@yuhs.ac |
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| Keywords | Carotid artery atherosclerosis Type 2 diabetes mellitus DM complication Proteinuria Diabetic kidney disease |
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| Snippet | •A high urine protein-to-creatinine ratio may be a useful and early predictive marker for the progression of carotid artery atherosclerosis , even in patients... This study aimed to evaluate the clinical significance of urine protein to creatinine ratio (uPCR) in relation to the cardiovascular risk associated with... |
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| SubjectTerms | Carotid artery atherosclerosis Diabetic kidney disease DM complication Proteinuria Type 2 diabetes mellitus |
| Title | Proteinuria as a significant predictive factor for the progression of carotid artery atherosclerosis in non-albuminuric type 2 diabetes |
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